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WASP Homolog-Associated Protein with Actin, Membranes and Microtubules (WHAMM) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1362303

MBS1362303 is a recombinant protein targeting WHAMM. Also known as Recombinant Human WASP homolog-associated protein with actin, membranes and microtubules (WHAMM) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
WASP homolog-associated protein with actin, membranes and microtubules (WHAMM), Recombinant Protein
Full Product Name
Recombinant Human WASP homolog-associated protein with actin, membranes and microtubules (WHAMM) , partial
Product Gene Name
WHAMM recombinant protein
Product Synonym Gene Name
WHAMM
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
90,924 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
612393
3D Structure
ModBase 3D Structure for Q8TF30
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of WHAMM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for WHAMM. It may not necessarily be applicable to this product.

NCBI GI #
122937271
NCBI GeneID
123720
NCBI Accession #
NP_001073904.1
UniProt Primary Accession #
Q8TF30
UniProt Secondary Accession #
Q8N1J9
UniProt Related Accession #
Q8TF30
GenBank Nucleotide #
NM_001080435.2
NCBI Official Full Name
WASP homolog-associated protein with actin, membranes and microtubules
NCBI Official Synonym Full Names
WAS protein homolog associated with actin, golgi membranes and microtubules
NCBI Official Symbol
WHAMM
NCBI Official Synonym Symbols
WHDC1; WHAMM1
UniProt Protein Name
WASP homolog-associated protein with actin, membranes and microtubules
UniProt Synonym Protein Names
WAS protein homology region 2 domain-containing protein 1; WH2 domain-containing protein 1
Protein Family
WASP homolog-associated protein
UniProt Gene Name
WHAMM
UniProt Synonym Gene Names
KIAA1971; WHDC1; WH2 domain-containing protein 1
NCBI Protein Information
WASP homolog-associated protein with actin, membranes and microtubules

NCBI Summary for WHAMM

This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. [provided by RefSeq, Aug 2013]
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UniProt Comments for WHAMM

Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration.
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Research Articles on WHAMM

1. WHAMM directs the Arp2/3 complex to the endoplasmic reticulum for autophagosome biogenesis through an actin comet tail mechanism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with WHAMM recombinant protein

 Reference Product  PubMed Publications
 FILIP1 recombinant protein  >1 publications with WHAMM and FILIP1

Diseases associated with WHAMM recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1 publications with WHAMM and Cardiovascular Diseases
 Inflammation Antibodies  >1 publications with WHAMM and Inflammation
 Necrosis Antibodies  >1 publications with WHAMM and Necrosis
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