Human CBY1 Recombinant Protein – Cat# MBS1362408

Protein Chibby Homolog 1 (CBY1) Human Recombinant Protein

Name: CBY1 Recombinant Protein; Protein Chibby Homolog 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1362408
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1362408

Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Protein chibby homolog 1 (CBY1), Recombinant Protein

Full Product Name

Recombinant Human Protein chibby homolog 1 (CBY1)

Product Gene Name

CBY1 recombinant protein

Product Synonym Gene Name

CBY1; ARB1; C22orf2; CBY; PGEA1; HRIHFB2025

Product Synonym Names

Protein chibby homolog 1; ARPP-binding protein; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1

Sequence

MPFFGNTFSP KKTPPRKSAS LSNLHSLDRS TREVELGLEY GSPTMNLAGQ SLKFENGQWI AETGVSGGVD RREVQRLRRR NQQLEEENNL LRLKVDILLD MLSESTAESH LMEKELDELR ISRKRK

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

41.5 kDa

Sequence Positions

1-126aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

607757

3D Structure

ModBase 3D Structure for Q9Y3M2

Species

Homo sapiens (Human)

Product Categories/Family for CBY1 recombinant protein

Signal Transduction

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CBY1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CBY1 purchase

MBS1362408 is a recombinant protein targeting CBY1. Also known as Recombinant Human Protein chibby homolog 1 (CBY1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CBY1. It may not necessarily be applicable to this product.

NCBI GI #

389886564

NCBI GeneID

25776

NCBI Accession #

NP_001002880.2

UniProt Primary Accession #

Q9Y3M2

UniProt Secondary Accession #

Q66GT6; Q9UIK9; B2R4S2

UniProt Related Accession #

Q9Y3M2

GenBank Nucleotide #

NM_001002880.1

NCBI Official Full Name

protein chibby homolog 1 isoform b

NCBI Official Synonym Full Names

chibby homolog 1 (Drosophila)

NCBI Official Symbol

CBY1

NCBI Official Synonym Symbols

CBY; arb1; PGEA1; C22orf2; PIGEA14; PIGEA-14; HS508I15A

UniProt Protein Name

Protein chibby homolog 1

UniProt Synonym Protein Names

ARPP-binding protein; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1

Protein Family

Protein chibby

UniProt Gene Name

CBY1

UniProt Synonym Gene Names

ARB1; C22orf2; CBY; PGEA1

UniProt Entry Name

CBY1_HUMAN

NCBI Protein Information

protein chibby homolog 1; ARPP-binding protein; coiled-coil protein PIGEA-14; cytosolic leucine-rich protein; chibby CTNNB1-mediated transcription inhibitor; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1; PKD2 interactor, golgi and endoplasmic reticulum associated 1; polycystin-2 interactor, Golgi- and endoplasmic reticulum-associated protein, 14 kDa

NCBI Summary for CBY1

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for CBY1

CBY1: Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 22q12

Cellular Component: nucleoplasm; nuclear speck; trans-Golgi network; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; beta-catenin binding

Biological Process: fat cell differentiation; protein localization; negative regulation of Wnt receptor signaling pathway; negative regulation of transcription, DNA-dependent; cardiac muscle cell differentiation

Research Articles on CBY1

1. Stable expression of CBY1 drives beta catenin cytoplasmatic translocation and impairs beta catenin signaling in BCR-ABL + cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CBY1 recombinant protein

Reference Product	PubMed Publications
CTNNB1 recombinant protein	>21 publications with CBY1 and CTNNB1

Pathways associated with CBY1 recombinant protein

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies	RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By WNT In Cancer Pathway antibodies	Signaling By WNT In Cancer Pathway Diagram
Signaling By Wnt Pathway antibodies	Signaling By Wnt Pathway Diagram
TCF Dependent Signaling In Response To WNT Pathway antibodies	TCF Dependent Signaling In Response To WNT Pathway Diagram
XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies	XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
Deactivation Of The Beta-catenin Transactivating Complex Pathway antibodies	Deactivation Of The Beta-catenin Transactivating Complex Pathway Diagram
Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies	Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram

Diseases associated with CBY1 recombinant protein

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>4 publications with CBY1 and Kidney Diseases
Lung Neoplasms Antibodies	>2 publications with CBY1 and Lung Neoplasms
Adenocarcinoma Antibodies	>1 publications with CBY1 and Adenocarcinoma

Organs/Tissues associated with CBY1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>5 publications with CBY1 and Kidney
Embryonic Tissue Antibodies	>4 publications with CBY1 and Embryonic Tissue
Thyroid Antibodies	>3 publications with CBY1 and Thyroid
Lung Antibodies	>3 publications with CBY1 and Lung
Muscle Antibodies	>2 publications with CBY1 and Muscle
Adipose Tissue Antibodies	>1 publications with CBY1 and Adipose Tissue
Heart Antibodies	>1 publications with CBY1 and Heart
Ovary Antibodies	>1 publications with CBY1 and Ovary
Stomach Antibodies	>1 publications with CBY1 and Stomach
Brain Antibodies	>1 publications with CBY1 and Brain