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E3 Ubiquitin-Protein Ligase TRIM68 (TRIM68) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1364668

This protein contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal… More details

$1265 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E3 ubiquitin-protein ligase TRIM68 (TRIM68), Recombinant Protein
Full Product Name
Recombinant Human E3 ubiquitin-protein ligase TRIM68 (TRIM68)
Product Gene Name
TRIM68 recombinant protein
Product Synonym Gene Name
TRIM68
Sequence
MDPTALVEAI VEEVACPICM TFLREPMSID CGHSFCHSCL SGLWEIPGES QNWGYTCPLC RAPVQPRNLR PNWQLANVVE KVRLLRLHPG MGLKGDLCER HGEKLKMFCK EDVLIMCEAC SQSPEHEAHS VVPMEDVAWE YKWELHEALE HLKKEQEEAW KLEVGERKRT ATWKIQVETR KQSIVWEFEK YQRLLEKKQP PHRQLGAEVA AALASLQREA AETMQKLELN HSELIQQSQV LWRMIAELKE RSQRPVRWML QDIQEVLNRS KSWSLQQPEP ISLELKTDCR VLGLREILKT YAADVRLDPD TAYSRLIVSE DRKRVHYGDT NQKLPDNPER FYRYNIVLGS QCISSGRHYW EVEVGDRSEW GLGVCKQNVD RKEVVYLSPH YGFWVIRLRK GNEYRAGTDE YPILSLPVPP RRVGIFVDYE AHDISFYNVT DCGSHIFTFP RYPFPGRLLP YFSPCYSIGT NNTAPLAICS LDGED
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
23,798 Da
Sequence Positions
1-485, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
613184
3D Structure
ModBase 3D Structure for Q6AZZ1
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TRIM68 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIM68 purchase

MBS1364668 is a recombinant protein targeting TRIM68. Also known as Recombinant Human E3 ubiquitin-protein ligase TRIM68 (TRIM68). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIM68. It may not necessarily be applicable to this product.

NCBI GI #
751557653
NCBI GeneID
55128
NCBI Accession #
NP_001291425.1
UniProt Primary Accession #
Q6AZZ1
UniProt Secondary Accession #
Q8WZ70; Q96LE5; Q96PF7; Q9H9C2; Q9NW18; A6NI19; A8K551; B3KPM5; B4DVK4
UniProt Related Accession #
Q6AZZ1
GenBank Nucleotide #
NM_001304496.1
NCBI Official Full Name
E3 ubiquitin-protein ligase TRIM68 isoform 2
NCBI Official Synonym Full Names
tripartite motif containing 68
NCBI Official Symbol
TRIM68
NCBI Official Synonym Symbols
SS56; GC109; SS-56; RNF137
UniProt Protein Name
E3 ubiquitin-protein ligase TRIM68
UniProt Synonym Protein Names
RING finger protein 137; RING-type E3 ubiquitin transferase TRIM68Curated; SSA protein SS-56; SS-56; Tripartite motif-containing protein 68
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
TRIM68
UniProt Synonym Gene Names
GC109; RNF137; SS56; SS-56
NCBI Protein Information
E3 ubiquitin-protein ligase TRIM68

NCBI Summary for TRIM68

This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
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UniProt Comments for TRIM68

Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.

Research Articles on TRIM68

1. TRIM68 targets TFG, a novel regulator of IFN production, and in doing so turns off and limits type I IFN production in response to anti-viral detection systems

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TRIM68 recombinant protein

 Reference Product  PubMed Publications
 KAT5 recombinant protein  >1 publications with TRIM68 and KAT5
 TFG recombinant protein  >1 publications with TRIM68 and TFG

Pathways associated with TRIM68 recombinant protein

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram

Diseases associated with TRIM68 recombinant protein

 Disease Name  Pubmed Publications
 Eye Diseases Antibodies  >2 publications with TRIM68 and Eye Diseases
 Inflammation Antibodies  >1 publications with TRIM68 and Inflammation

Organs/Tissues associated with TRIM68 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >2 publications with TRIM68 and Prostate
 Blood Antibodies  >2 publications with TRIM68 and Blood
 Skin Antibodies  >1 publications with TRIM68 and Skin
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