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Ral Gtpase-Activating Protein Subunit Alpha-1 (RALGAPA1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1365443

MBS1365443 is a recombinant protein targeting RALGAPA1. Also known as Recombinant Human Ral GTPase-activating protein subunit alpha-1 (RALGAPA1) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$2110 / 0.5 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ral GTPase-activating protein subunit alpha-1 (RALGAPA1), Recombinant Protein
Full Product Name
Recombinant Human Ral GTPase-activating protein subunit alpha-1 (RALGAPA1) , partial
Product Gene Name
RALGAPA1 recombinant protein
Product Synonym Gene Name
RALGAPA1
Sequence
FTNKTVAHVA CNMLHMLVHY VPRLQIYQPD SPLKIIQILI ATITHLLPST EASSYEMDKR LVVSLLLCLL DWIMALPLKT LLQPFHATGA ESDKTEKSVL NCIYKVLHGC VYGAQCFSNP RYFPMSLSDL ASVDYDPFMH LESLKEPEPL HSPDSERSSK LQPVTEVKTQ MQHGLISIAA RTVITHLVNH LGHYPMSGGP AMLTSQVCEN HDNHYSESTE LSPELFESPN IQFFVLNNTT LVSCIQIRSE ENMPGGGLSA GLASANSNVR IIVRDLSGKY SWDSAILYGP PPVSGLSEPT SFMLSLSHQE KPEEPPTSNE CLEDITVKDG LSLQFKRFRE TVPTWDTIRD EEDVLDELLQ YLGVTSPECL QRTGISLNIP APQPVCISEK QENDVINAIL KQHTEEKEFV EKHFNDLNMK AVEQDEPIPQ KPQSAFYYCR LLLSILGMNS WDKRRSFHLL KKNEKLLREL RNLDSRQCRE THKIAVFYVA EGQEDKHSIL TNTGGSQAYE DFVAGLGWEV NLTNHCGFMG GLQKNKSTGL TTPYFATSTV EVIFHVSTRM PSDSDDSLTK KLRHLGNDEV HIVWSEHTRD YRRGIIPTEF GDVLIVIYPM KNHMFSIQIM KKPEVPFFGP LFDGAIVNGK VLPIMVRATA INASRALKSL IPLYQNFYEE RARYLQTIVQ HHLEPTTFED FAAQVFSPAP YHHLPSDAD
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
231,138 Da
Sequence Positions
1327-2035, Partial, provide the Minimal domain that binds to TCF3/E12 include the Rap-GAP domain.
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
608884
3D Structure
ModBase 3D Structure for Q6GYQ0
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RALGAPA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RALGAPA1. It may not necessarily be applicable to this product.

NCBI GI #
545688888
NCBI GeneID
253959
NCBI Accession #
NP_001269972.1
UniProt Primary Accession #
Q6GYQ0
UniProt Secondary Accession #
O94960; Q6GYP9; Q6ZT23; Q86YF3; Q86YF5; Q8ND69; A6NMA4; B9EK38; C5NU19
UniProt Related Accession #
Q6GYQ0
GenBank Nucleotide #
NM_001283043.2
NCBI Official Full Name
ral GTPase-activating protein subunit alpha-1 isoform 3
NCBI Official Synonym Full Names
Ral GTPase activating protein catalytic alpha subunit 1
NCBI Official Symbol
RALGAPA1
NCBI Official Synonym Symbols
p240; GRIPE; GARNL1; TULIP1; RalGAPalpha1
UniProt Protein Name
Ral GTPase-activating protein subunit alpha-1
UniProt Synonym Protein Names
GAP-related-interacting partner to E12; GRIPE; GTPase-activating Rap/Ran-GAP domain-like 1; Tuberin-like protein 1; p240
Protein Family
Ral GTPase-activating protein
UniProt Gene Name
RALGAPA1
UniProt Synonym Gene Names
GARNL1; KIAA0884; TULIP1; GRIPE
NCBI Protein Information
ral GTPase-activating protein subunit alpha-1

NCBI Summary for RALGAPA1

This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016]
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UniProt Comments for RALGAPA1

Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.

Research Articles on RALGAPA1

1. GARNL1/RalGAPalpha1 is amajor RalGAPalphasubunit in skeletal muscle, and is regulated by protein phosphorylation and 14-3-3 binding upon stimulation with insulin or muscle contraction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with RALGAPA1 recombinant protein

 Products by Pathway  Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram

Diseases associated with RALGAPA1 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with RALGAPA1 and Nervous System Diseases

Organs/Tissues associated with RALGAPA1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >2 publications with RALGAPA1 and Nerve
 Brain Antibodies  >2 publications with RALGAPA1 and Brain
 Muscle Antibodies  >1 publications with RALGAPA1 and Muscle
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