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Rho Guanine Nucleotide Exchange Factor 7 (ARHGEF7) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1365908

Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rho guanine nucleotide exchange factor 7 (ARHGEF7), Recombinant Protein
Full Product Name
Recombinant Human Rho guanine nucleotide exchange factor 7 (ARHGEF7) , partial
Product Gene Name
ARHGEF7 recombinant protein
Product Synonym Gene Name
ARHGEF7
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
54.8 kDa
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605477
3D Structure
ModBase 3D Structure for Q14155
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ARHGEF7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARHGEF7 purchase

MBS1365908 is a recombinant protein targeting ARHGEF7. Also known as Recombinant Human Rho guanine nucleotide exchange factor 7 (ARHGEF7) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGEF7. It may not necessarily be applicable to this product.

NCBI GI #
166064034
NCBI GeneID
8874
NCBI Accession #
NP_001106983.1
UniProt Primary Accession #
Q14155
UniProt Secondary Accession #
Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1; B1ALK6; B1ALK8
UniProt Related Accession #
Q14155
GenBank Nucleotide #
NM_001113511.2
NCBI Official Full Name
rho guanine nucleotide exchange factor 7 isoform c
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor 7
NCBI Official Symbol
ARHGEF7
NCBI Official Synonym Symbols
P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314
UniProt Protein Name
Rho guanine nucleotide exchange factor 7
UniProt Synonym Protein Names
Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85
Protein Family
Rho guanine nucleotide exchange factor
UniProt Gene Name
ARHGEF7
UniProt Synonym Gene Names
COOL1; KIAA0142; P85SPR; PAK3BP; PIXB
NCBI Protein Information
rho guanine nucleotide exchange factor 7

NCBI Summary for ARHGEF7

This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
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UniProt Comments for ARHGEF7

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
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Research Articles on ARHGEF7

1. S340E mutation enhances Nox1 activation (Kaito et al., 2014), the present study suggests that betaPix can also play an inhibitory role in O2(-) production, depending on the sites of phosphorylation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ARHGEF7 recombinant protein

 Reference Product  PubMed Publications
 RAC1 recombinant protein  >6 publications with ARHGEF7 and RAC1
 CDC42 recombinant protein  >4 publications with ARHGEF7 and CDC42
 PAK1 recombinant protein  >3 publications with ARHGEF7 and PAK1
 ARHGEF6 recombinant protein  >1 publications with ARHGEF7 and ARHGEF6

Pathways associated with ARHGEF7 recombinant protein

 Products by Pathway  Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR Downregulation Pathway antibodies  EGFR Downregulation Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Internalization Of ErbB1 Pathway antibodies  Internalization Of ErbB1 Pathway Diagram

Diseases associated with ARHGEF7 recombinant protein

 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >2 publications with ARHGEF7 and Neurobehavioral Manifestations
 Neoplasms Antibodies  >2 publications with ARHGEF7 and Neoplasms
 Nervous System Diseases Antibodies  >2 publications with ARHGEF7 and Nervous System Diseases
 Carcinoma Antibodies  >1 publications with ARHGEF7 and Carcinoma
 Kidney Diseases Antibodies  >1 publications with ARHGEF7 and Kidney Diseases

Organs/Tissues associated with ARHGEF7 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with ARHGEF7 and Kidney
 Embryonic Tissue Antibodies  >1 publications with ARHGEF7 and Embryonic Tissue
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