Mouse NPM1 Recombinant Protein – Cat# MBS1366239

Nucleophosmin (NPM1) Mouse Recombinant Protein

Name: NPM1 Recombinant Protein; Nucleophosmin; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1366239
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1366239

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nucleophosmin (Npm1), Recombinant Protein

Full Product Name

Recombinant Mouse Nucleophosmin (Npm1)

Product Gene Name

Npm1 recombinant protein

Product Synonym Names

Nucleophosmin; NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin

Sequence

MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ ASIEKGGSLP KVEAKFINYV KNCFRMTDQE AIQDLWQWRK SL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

48.6 kDa

Sequence Positions

1-292aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for Q61937

Species

Mus musculus (Mouse)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for Npm1 recombinant protein

Epigenetics and Nuclear Signaling

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Npm1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Npm1 purchase

MBS1366239 is a recombinant protein targeting Npm1. Also known as Recombinant Mouse Nucleophosmin (Npm1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Npm1. It may not necessarily be applicable to this product.

NCBI GI #

6679108

NCBI GeneID

18148

NCBI Accession #

NP_032748.1

UniProt Primary Accession #

Q61937

UniProt Related Accession #

Q61937

GenBank Nucleotide #

NM_008722.3

NCBI Official Full Name

nucleophosmin isoform 1

NCBI Official Synonym Full Names

nucleophosmin 1

NCBI Official Symbol

Npm1

NCBI Official Synonym Symbols

B23; Npm; NO38

UniProt Protein Name

Nucleophosmin

UniProt Synonym Protein Names

Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin

Protein Family

Nucleophosmin

UniProt Gene Name

Npm1

UniProt Synonym Gene Names

NPM

UniProt Entry Name

NPM_MOUSE

NCBI Protein Information

nucleophosmin; numatrin; nucleolar protein NO38; nucleolar phosphoprotein B23

UniProt Comments for Npm1

NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described.

Protein type: RNA-binding; Nucleolus; Oncoprotein; Translation

Cellular Component: centrosome; small ribosomal subunit; granular component; focal adhesion; cell; spindle pole centrosome; ribonucleoprotein complex; cytosol; nucleoplasm; cytoskeleton; membrane; cytoplasm; nucleolus; nuclear speck; intracellular; nucleus; large ribosomal subunit

Molecular Function: protein homodimerization activity; protein kinase inhibitor activity; histone binding; RNA binding; unfolded protein binding; transcription coactivator activity; protein kinase binding; ribosomal large subunit binding; rRNA binding; NF-kappaB binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; enzyme binding; DNA binding; nucleic acid binding; protein heterodimerization activity; Tat protein binding; ribosomal small subunit binding

Biological Process: positive regulation of catalytic activity; positive regulation of DNA metabolic process; regulation of centriole replication; positive regulation of translation; regulation of cell cycle; centrosome cycle; nucleocytoplasmic transport; ribosomal large subunit biogenesis and assembly; ribosomal large subunit export from nucleus; regulation of DNA damage response, signal transduction by p53 class mediator; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; protein localization; regulation of neuron apoptosis; positive regulation of cell proliferation; response to stress; cell growth; protein homooligomerization; ribosomal small subunit export from nucleus; protein destabilization; cell aging; DNA repair; positive regulation of cellular biosynthetic process; protein oligomerization; nucleosome assembly; ribosomal small subunit biogenesis and assembly; rRNA export from nucleus; regulation of endodeoxyribonuclease activity; negative regulation of nuclear mRNA splicing, via spliceosome; positive regulation of protein kinase activity; cell volume homeostasis; positive regulation of DNA replication; negative regulation of apoptosis

Research Articles on Npm1

1. In conclusion, we successfully established xenotransplantation model of human FLT3-ITD (mut) /NPM1 (-) CN-AML in NOD/SCID mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Npm1 recombinant protein

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Chromosome Maintenance Pathway antibodies	Chromosome Maintenance Pathway Diagram
Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies	Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
Nucleosome Assembly Pathway antibodies	Nucleosome Assembly Pathway Diagram
MRNA Processing Pathway antibodies	MRNA Processing Pathway Diagram

Diseases associated with Npm1 recombinant protein

Disease Name	Pubmed Publications
Leukemia, Myeloid, Acute Antibodies	>614 publications with Npm1 and Leukemia, Myeloid, Acute
Cell Transformation, Neoplastic Antibodies	>32 publications with Npm1 and Cell Transformation, Neoplastic
Leukemia, Promyelocytic, Acute Antibodies	>21 publications with Npm1 and Leukemia, Promyelocytic, Acute
Carcinoma Antibodies	>21 publications with Npm1 and Carcinoma
Anemia Antibodies	>14 publications with Npm1 and Anemia
Adenocarcinoma Antibodies	>10 publications with Npm1 and Adenocarcinoma
Breast Neoplasms Antibodies	>9 publications with Npm1 and Breast Neoplasms
Neoplasms, Experimental Antibodies	>7 publications with Npm1 and Neoplasms, Experimental
Neoplasm Metastasis Antibodies	>5 publications with Npm1 and Neoplasm Metastasis
Lung Neoplasms Antibodies	>5 publications with Npm1 and Lung Neoplasms

Organs/Tissues associated with Npm1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>225 publications with Npm1 and Blood
Other Antibodies	>182 publications with Npm1 and Other
Bone Antibodies	>145 publications with Npm1 and Bone
Bone Marrow Antibodies	>143 publications with Npm1 and Bone Marrow
Lung Antibodies	>9 publications with Npm1 and Lung
Brain Antibodies	>7 publications with Npm1 and Brain
Skin Antibodies	>5 publications with Npm1 and Skin
Heart Antibodies	>4 publications with Npm1 and Heart
Prostate Antibodies	>4 publications with Npm1 and Prostate
Spleen Antibodies	>4 publications with Npm1 and Spleen