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Huntingtin-Interacting Protein 1 (HIP1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1372183

The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Huntingtin-interacting protein 1 (Hip1), Recombinant Protein
Full Product Name
Recombinant Mouse Huntingtin-interacting protein 1 (Hip1) , partial
Product Gene Name
Hip1 recombinant protein
Product Synonym Gene Name
Hip1
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
115,202 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8VD75
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Hip1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hip1 purchase

MBS1372183 is a recombinant protein targeting Hip1. Also known as Recombinant Mouse Huntingtin-interacting protein 1 (Hip1) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Hip1. It may not necessarily be applicable to this product.

NCBI GI #
225007582
NCBI GeneID
215114
NCBI Accession #
NP_666113.2
UniProt Primary Accession #
Q8VD75
UniProt Secondary Accession #
Q3TLS2; Q571K7
UniProt Related Accession #
Q8VD75
GenBank Nucleotide #
NM_146001.2
NCBI Official Full Name
huntingtin-interacting protein 1
NCBI Official Synonym Full Names
huntingtin interacting protein 1
NCBI Official Symbol
Hip1
NCBI Official Synonym Symbols
mKIAA4113; 2610109B09Rik; A930014B11Rik; E130315I21Rik
UniProt Protein Name
Huntingtin-interacting protein 1
UniProt Synonym Protein Names
Huntingtin-interacting protein I; HIP-I
Protein Family
High-potential iron-sulfur protein
UniProt Gene Name
Hip1
UniProt Synonym Gene Names
HIP-1; HIP-I
NCBI Protein Information
huntingtin-interacting protein 1

UniProt Comments for Hip1

Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11577110). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (PubMed:12839988, PubMed:17329427). Regulates presynaptic nerve terminal activity (PubMed:17928447). Enhances androgen receptor (AR)-mediated transcription (). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (). Binds 3-phosphoinositides (via ENTH domain) (). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (). May play a functional role in the cell filament networks (). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11604514, PubMed:14998932, PubMed:16967501, PubMed:17928447).
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Research Articles on Hip1

1. we show that M. tuberculosis impairs dendritic cell cytokine secretion, maturation, and antigen presentation through the cell envelope-associated serine hydrolase, Hip1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Hip1 recombinant protein

 Reference Product  PubMed Publications
 Htt recombinant protein  >24 publications with Hip1 and Htt
 Ap2b1 recombinant protein  >1 publications with Hip1 and Ap2b1
 Ap2a2 recombinant protein  >1 publications with Hip1 and Ap2a2

Pathways associated with Hip1 recombinant protein

 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram

Diseases associated with Hip1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >26 publications with Hip1 and Neoplasms
 Genital Diseases, Male Antibodies  >7 publications with Hip1 and Genital Diseases, Male
 Prostatic Diseases Antibodies  >6 publications with Hip1 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >6 publications with Hip1 and Prostatic Neoplasms
 Skin Diseases Antibodies  >5 publications with Hip1 and Skin Diseases
 Breast Neoplasms Antibodies  >4 publications with Hip1 and Breast Neoplasms
 Congenital Abnormalities Antibodies  >3 publications with Hip1 and Congenital Abnormalities
 Adenocarcinoma Antibodies  >3 publications with Hip1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >2 publications with Hip1 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >2 publications with Hip1 and Neoplasm Metastasis

Organs/Tissues associated with Hip1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >36 publications with Hip1 and Brain
 Bone Antibodies  >3 publications with Hip1 and Bone
 Skin Antibodies  >3 publications with Hip1 and Skin
 Bone Marrow Antibodies  >2 publications with Hip1 and Bone Marrow
 Heart Antibodies  >2 publications with Hip1 and Heart
 Liver Antibodies  >2 publications with Hip1 and Liver
 Spleen Antibodies  >2 publications with Hip1 and Spleen
 Embryonic Tissue Antibodies  >2 publications with Hip1 and Embryonic Tissue
 Lung Antibodies  >1 publications with Hip1 and Lung
 Pancreas Antibodies  >1 publications with Hip1 and Pancreas
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