• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Extracellular Serine/Threonine Protein Kinase FAM20C (FAM20C) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1372422

MBS1372422 is a recombinant protein targeting FAM20C. Also known as Recombinant Human Extracellular serine/threonine protein kinase FAM20C (FAM20C). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$245 / 0.02 mg (Mammalian-Cell) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Extracellular serine/threonine protein kinase FAM20C (FAM20C), Recombinant Protein
Full Product Name
Recombinant Human Extracellular serine/threonine protein kinase FAM20C (FAM20C)
Product Gene Name
FAM20C recombinant protein
Product Synonym Gene Name
FAM20C
Sequence
DFSSDPSSNL SSHSLEKLPP AAEPAERALR GRDPGALRPH DPAHRPLLRD PGPRRSESPP GPGGDASLLA RLFEHPLYRV AVPPLTEEDV LFNVNSDTRL SPKAAENPDW PHAGAEGAEF LSPGEAAVDS YPNWLKFHIG INRYELYSRH NPAIEALLHD LSSQRITSVA MKSGGTQLKL IMTFQNYGQA LFKPMKQTRE QETPPDFFYF SDYERHNAEI AAFHLDRILD FRRVPPVAGR MVNMTKEIRD VTRDKKLWRT FFISPANNIC FYGECSYYCS TEHALCGKPD QIEGSLAAFL PDLSLAKRKT WRNPWRRSYH KRKKAEWEVD PDYCEEVKQT PPYDSSHRIL DVMDMTIFDF LMGNMDRHHY ETFEKFGNET FIIHLDNGRG FGKYSHDELS ILVPLQQCCR IRKSTYLRLQ LLAKEEYKLS LLMAESLRGD QVAPVLYQPH LEALDRRLRV VLKAVRDCVE RNGLHSVVDD DLDTEHRAAS AR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
60.4 kDa
Sequence Positions
93-584aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
259775
3D Structure
ModBase 3D Structure for Q8IXL6
Species
Homo sapiens (Human)
Production Note
Special Offer: The Mammalian-Cell host-expressed protein is manufactured from a stock plasmid containing the protein gene. Mammalian-Cellhost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Mammalian-Cell host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Mammalian-Cell host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of FAM20C recombinant protein

Human FAM20C Recombinant Protein – Cat# MBS1372422

Other Notes

Small volumes of FAM20C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FAM20C. It may not necessarily be applicable to this product.

NCBI GI #
116174742
NCBI GeneID
56975
NCBI Accession #
NP_064608.2
UniProt Primary Accession #
Q8IXL6
UniProt Secondary Accession #
Q5I0W9; Q7Z4I0; Q9NPT2; A4D2Q5; L8B5W8
UniProt Related Accession #
Q8IXL6
GenBank Nucleotide #
NM_020223.3
NCBI Official Full Name
extracellular serine/threonine protein kinase FAM20C
NCBI Official Synonym Full Names
FAM20C, golgi associated secretory pathway kinase
NCBI Official Symbol
FAM20C
NCBI Official Synonym Symbols
RNS; DMP4; G-CK; DMP-4; GEF-CK
UniProt Protein Name
Extracellular serine/threonine protein kinase FAM20C
UniProt Synonym Protein Names
Dentin matrix protein 4
Protein Family
Extracellular serine/threonine protein kinase
UniProt Gene Name
FAM20C
UniProt Synonym Gene Names
GEF-CK
NCBI Protein Information
extracellular serine/threonine protein kinase FAM20C

NCBI Summary for FAM20C

This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Apr 2014]

UniProt Comments for FAM20C

Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039).
Show more

Research Articles on FAM20C

1. findings clarify FAM20C's role in hard tissue formation and mineralization, and show that Raine syndrome is congenital sclerosing osteomalacia with cerebral calcification.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with FAM20C recombinant protein

 Disease Name  Pubmed Publications
 Raine syndrome Antibodies  >14 publications with FAM20C and Raine syndrome
 Nervous System Diseases Antibodies  >5 publications with FAM20C and Nervous System Diseases
 Nervous System Malformations Antibodies  >4 publications with FAM20C and Nervous System Malformations
 Chromosome Aberrations Antibodies  >2 publications with FAM20C and Chromosome Aberrations
 Disease Models, Animal Antibodies  >2 publications with FAM20C and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >1 publications with FAM20C and Neoplasm Metastasis
 Inflammation Antibodies  >1 publications with FAM20C and Inflammation
 Lung Neoplasms Antibodies  >1 publications with FAM20C and Lung Neoplasms
 Adenocarcinoma Antibodies  >1 publications with FAM20C and Adenocarcinoma
 Hyperplasia Antibodies  >1 publications with FAM20C and Hyperplasia

Organs/Tissues associated with FAM20C recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >31 publications with FAM20C and Bone
 Connective Tissue Antibodies  >5 publications with FAM20C and Connective Tissue
 Blood Antibodies  >4 publications with FAM20C and Blood
 Kidney Antibodies  >3 publications with FAM20C and Kidney
 Embryonic Tissue Antibodies  >1 publications with FAM20C and Embryonic Tissue
 Lung Antibodies  >1 publications with FAM20C and Lung
 Mammary Gland Antibodies  >1 publications with FAM20C and Mammary Gland
 Vascular Antibodies  >1 publications with FAM20C and Vascular
 Muscle Antibodies  >1 publications with FAM20C and Muscle
 Brain Antibodies  >1 publications with FAM20C and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000