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CCR4-NOT Transcription Complex Subunit 6 (CNOT6) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1372918

This protein is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3 -5 RNase activity and prefers polyadenylated substates. More details

$1350 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCR4-NOT transcription complex subunit 6 (Cnot6), Recombinant Protein
Full Product Name
Recombinant Rat CCR4-NOT transcription complex subunit 6 (Cnot6)
Product Gene Name
Cnot6 recombinant protein
Product Synonym Gene Name
Cnot6
Sequence
MPKEKYEPPD PRRMYTIMSS EEAANGKKSH WAELEISGKV RSLSSSLWSL THLTALHLSD NSLSCIPSDI AKLHNLVYLD LSHNQIQSLP AELGNMVSLR ELHLNYNQLR VLPFELGKLF QLQTLSLKGN PLTQDILNLC LEPDGTRRLL NYLLDNLSGT AKRISTEQPP PRSWIMLQEP DRTRPTALFS VMCYNVLCDK YATRQLYGYC PSWALNWDYR KKAIIQEILS CNADIISLQE VETEQYYSFF LVELKERGYN GFFSPKSRAR TMSEQERKHV DGCAIFFKTE KFTLVQKHTV EFNQLAMANS EGSEAMLNRV MTKDNIGVAV LLELRKELIE MSSGKPHLGT EKQLILVANA HMHWDPEYSD VKLVQTMMFL SEVKNIIDKA SRSLKSSVLG ECGTIPLVLC ADLNSLPDSG VVEYLSTGGV ETNHKDFKEL RYNESLTNFS CNGKNGMTNG RITHGFKLKS AYENGLMPYT NYTFDFKGII DYIFYSKPQL NTLAILGPLD HHWLVENNIS GCPHPLIPSD HFSLFAQLEL LLPFLPQVNG IHLPGRR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
63,304 Da
Sequence Positions
1-557, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q6AXU9
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cnot6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cnot6 purchase

MBS1372918 is a recombinant protein targeting Cnot6. Also known as Recombinant Rat CCR4-NOT transcription complex subunit 6 (Cnot6). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Cnot6. It may not necessarily be applicable to this product.

NCBI GI #
62078445
NCBI GeneID
287249
NCBI Accession #
NP_001013878.1
UniProt Primary Accession #
Q6AXU9
UniProt Related Accession #
Q6AXU9
GenBank Nucleotide #
NM_001013856.1
NCBI Official Full Name
CCR4-NOT transcription complex subunit 6
NCBI Official Synonym Full Names
CCR4-NOT transcription complex, subunit 6
NCBI Official Symbol
Cnot6
NCBI Official Synonym Symbols
CCR4; RGD1310783
UniProt Protein Name
CCR4-NOT transcription complex subunit 6
UniProt Synonym Protein Names
CCR4 carbon catabolite repression 4-like; Carbon catabolite repressor protein 4 homolog; Cytoplasmic deadenylase
Protein Family
CCR4-NOT transcription complex
UniProt Gene Name
Cnot6
UniProt Synonym Gene Names
Ccr4
NCBI Protein Information
CCR4-NOT transcription complex subunit 6

UniProt Comments for Cnot6

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors. Mediates cell proliferation and cell survival and prevents cellular senescence ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Cnot6 recombinant protein

 Reference Product  PubMed Publications
 Cnot7 recombinant protein  >6 publications with Cnot6 and Cnot7
 Cnot8 recombinant protein  >5 publications with Cnot6 and Cnot8
 Cnot2 recombinant protein  >2 publications with Cnot6 and Cnot2
 Pan2 recombinant protein  >1 publications with Cnot6 and Pan2
 Rqcd1 recombinant protein  >1 publications with Cnot6 and Rqcd1

Pathways associated with Cnot6 recombinant protein

 Products by Pathway  Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram

Diseases associated with Cnot6 recombinant protein

 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >1 publications with Cnot6 and Abnormalities, Multiple
 Abnormalities, Drug-Induced Antibodies  >1 publications with Cnot6 and Abnormalities, Drug-Induced

Organs/Tissues associated with Cnot6 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with Cnot6 and Brain
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