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Tuberin (TSC2) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1374816

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for… More details

$900 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tuberin (Tsc2), Recombinant Protein
Full Product Name
Recombinant Mouse Tuberin (Tsc2) , partial
Product Gene Name
Tsc2 recombinant protein
Product Synonym Gene Name
Tsc2
Sequence
VQLLDQIPSY DTHKIAVLYV GEGQSSSELA ILSNEHGSYR YTEFLTGLGR LIELKDCQPD KVYLGGLDVC GEDGQFTYCW HDDIMQAVFH IATLMPTKDV DKHRCDKKRH LGNDFVSIIY NDSGEDFKLG TIKQGQFNFV HVIITPLDYK CNLLTLQCRK DGPACKCEWW RQPGEIVVWA LPVVMELTVT ILLCHLQMAS QVHHSRSNPT DIYPSKWIAR LRHIKRLRQR IREEV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
189,855 Da
Sequence Positions
1532-1766aa; Partial (ap-GAP domain)
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q61037
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tsc2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tsc2 purchase

MBS1374816 is a recombinant protein targeting Tsc2. Also known as Recombinant Mouse Tuberin (Tsc2) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Tsc2. It may not necessarily be applicable to this product.

NCBI GI #
9297076
NCBI GeneID
22084
NCBI Accession #
Q61037.1
UniProt Primary Accession #
Q61037
UniProt Secondary Accession #
P97723; P97724; P97725; P97727; Q61007; Q61008; Q9WUF6
UniProt Related Accession #
Q61037
NCBI Official Full Name
Tuberin
NCBI Official Synonym Full Names
tuberous sclerosis 2
NCBI Official Symbol
Tsc2
NCBI Official Synonym Symbols
Tcs2; Nafld
UniProt Protein Name
Tuberin
UniProt Synonym Protein Names
Tuberous sclerosis 2 protein homolog
Protein Family
Tuberin
UniProt Gene Name
Tsc2
NCBI Protein Information
tuberin

UniProt Comments for Tsc2

In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
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Research Articles on Tsc2

1. TSC loss distorts DNA replication programme and sensitises murine embryonic fibroblasts to genotoxic stress.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Tsc2 recombinant protein

 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram

Organs/Tissues associated with Tsc2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >349 publications with Tsc2 and Brain
 Kidney Antibodies  >291 publications with Tsc2 and Kidney
 Other Antibodies  >279 publications with Tsc2 and Other
 Muscle Antibodies  >160 publications with Tsc2 and Muscle
 Lung Antibodies  >149 publications with Tsc2 and Lung
 Heart Antibodies  >120 publications with Tsc2 and Heart
 Skin Antibodies  >113 publications with Tsc2 and Skin
 Blood Antibodies  >103 publications with Tsc2 and Blood
 Liver Antibodies  >77 publications with Tsc2 and Liver
 Embryonic Tissue Antibodies  >30 publications with Tsc2 and Embryonic Tissue
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