• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TGF-Beta-Activated Kinase 1 and MAP3K7-Binding Protein 3 (TAB3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1375003

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2TAB2, forms a ternary complex with the protein kinase MAP3K7TAK1 and either TRAF2 or TRAF6 in… More details

$1555 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (TAB3), Recombinant Protein
Full Product Name
Recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (TAB3)
Product Gene Name
TAB3 recombinant protein
Product Synonym Gene Name
TAB3
Sequence
AQSSPQLDIQ VLHDLRQRFP EIPEGVVSQC MLQNNNNLEA CCRALSQESS KYLYMEYHSP DDNRMNRNRL LHINLGIHSP SSYHPGDGAQ LNGGRTLVHS SSDGHIDPQH AAGKQLICLV QEPHSAPAVV AATPNYNPFF MNEQNRSAAT PPSQPPQQPS SMQTGMNPSA MQGPSPPPPP PSYMHIPRYS TNPITVTVSQ NLPSGQTVPR ALQILPQIPS NLYGSPGSIY IRQTSQSSSG RQTPQSTPWQ SSPQGPVPHY SQRPLPVYPH QQNYQPSQYS PKQQQIPQSA YHSPPPSQCP SPFSSPQHQV QPSQLGHIFM PPSPSTTPPH PYQQGPPSYQ KQGSHSVAYL PYTASSLSKG SMKKIEITVE PSQRPGTAIN RSPSPISNQP SPWNQHSLYT ATTPPSSSPS RGISSQPKPP FSVNPVYITY TQPTGPSCTP SPSPRVIPNP TTVFKITVGR ATTENLLNLV DQEERSAAPE PIQPISVIPG SGGEKGSHKY QRSSSSGSDD YAYTQALLLH QRARMERLAK QLKLEKEELE RLKSEVNGME HDLMQRRLRR VSCTTAIPTP EEMTRLRSMN RQLQINVDCT LKEVDLLQSR GNFDPKAMNN FYDNIEPGPV VPPKPSKKDS SDPCTIERKA RRISVTSKVQ ADIHDTQAAA ADEHRTGSTQ SPRTQPRDED YEGAPWNCDS CTFLNHPALN RCEQCEMPRY T
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
75,599 Da
Sequence Positions
2-712, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
300480
3D Structure
ModBase 3D Structure for Q8N5C8
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TAB3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAB3 purchase

MBS1375003 is a recombinant protein targeting TAB3. Also known as Recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (TAB3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TAB3. It may not necessarily be applicable to this product.

NCBI GI #
730229395
NCBI GeneID
257397
NCBI Accession #
NP_690000.3
UniProt Primary Accession #
Q8N5C8
UniProt Secondary Accession #
Q6VQR0; A6NDD9
UniProt Related Accession #
Q8N5C8
GenBank Nucleotide #
NM_152787.4
NCBI Official Full Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
NCBI Official Synonym Full Names
TGF-beta activated kinase 1 (MAP3K7) binding protein 3
NCBI Official Symbol
TAB3
NCBI Official Synonym Symbols
NAP1; MAP3K7IP3
UniProt Protein Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
UniProt Synonym Protein Names
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; TAK1-binding protein 3; TAB-3; TGF-beta-activated kinase 1-binding protein 3
Protein Family
TGF-beta-activated kinase 1 and MAP3K7-binding protein
UniProt Gene Name
TAB3
UniProt Synonym Gene Names
MAP3K7IP3; TAB-3
NCBI Protein Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

NCBI Summary for TAB3

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for TAB3

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Research Articles on TAB3

1. The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 signaling as a novel pathogenic substrate for polyvalvular syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TAB3 recombinant protein

 Reference Product  PubMed Publications
 TAB2 recombinant protein  >32 publications with TAB3 and TAB2
 TAB1 recombinant protein  >13 publications with TAB3 and TAB1
 TRAF6 recombinant protein  >7 publications with TAB3 and TRAF6
 IKBKB recombinant protein  >6 publications with TAB3 and IKBKB
 IRAK2 recombinant protein  >3 publications with TAB3 and IRAK2
 MAP3K7 recombinant protein  >2 publications with TAB3 and MAP3K7
 CHUK recombinant protein  >1 publications with TAB3 and CHUK

Pathways associated with TAB3 recombinant protein

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 CLEC7A (Dectin-1) Signaling Pathway antibodies  CLEC7A (Dectin-1) Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 FCERI Mediated NF-kB Activation Pathway antibodies  FCERI Mediated NF-kB Activation Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 IRAK2 Mediated Activation Of TAK1 Complex Pathway antibodies  IRAK2 Mediated Activation Of TAK1 Complex Pathway Diagram
 IRAK2 Mediated Activation Of TAK1 Complex Upon TLR7/8 Or 9 Stimulation Pathway antibodies  IRAK2 Mediated Activation Of TAK1 Complex Upon TLR7/8 Or 9 Stimulation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with TAB3 recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >15 publications with TAB3 and Necrosis
 Inflammation Antibodies  >9 publications with TAB3 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >4 publications with TAB3 and Carcinoma, Hepatocellular
 Immune System Diseases Antibodies  >4 publications with TAB3 and Immune System Diseases
 Liver Diseases Antibodies  >4 publications with TAB3 and Liver Diseases
 Liver Neoplasms Antibodies  >4 publications with TAB3 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with TAB3 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >1 publications with TAB3 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with TAB3 and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with TAB3 and Disease Models, Animal

Organs/Tissues associated with TAB3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with TAB3 and Liver
 Blood Antibodies  >3 publications with TAB3 and Blood
 Intestine Antibodies  >2 publications with TAB3 and Intestine
 Kidney Antibodies  >2 publications with TAB3 and Kidney
 Lung Antibodies  >1 publications with TAB3 and Lung
 Embryonic Tissue Antibodies  >1 publications with TAB3 and Embryonic Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000