Lymphocyte Antigen 96 (LY96) Mouse Recombinant Protein

LY96: a secreted protein that binds to the extracellular domains of TLR2 and TLR4. Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor complex, a multi-protein complex containing at least CD14, LY96 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular region; intrinsic to plasma membrane; lipopolysaccharide receptor complex

Molecular Function: lipopolysaccharide receptor activity; protein binding

Biological Process: detection of lipopolysaccharide; immune system process; inflammatory response; innate immune response; lipopolysaccharide-mediated signaling pathway; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of tumor necrosis factor production; response to lipopolysaccharide; toll-like receptor 4 signaling pathway