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Mckusick-Kaufman/Bardet-Biedl Syndromes Putative Chaperonin (MKKS) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1376232

This gene encodes a protein with sequence similarity to the chaperonin family. The encoded protein may have a role in protein processing in limb, cardiac and reproductive system development. Mutations in this gene have been observed in patients with… More details

$1360 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Mkks), Recombinant Protein
Full Product Name
Recombinant Mouse McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Mkks)
Product Gene Name
Mkks recombinant protein
Product Synonym Gene Name
Mkks
Sequence
MSRLEAKKPS LCKTEPLTSE KVRSTLSVLK GVIASCYGPS GRLKQLHNGL GGCVYTTSQS SALLRNLSVT HPVLKILTSS VQNHVSCFSD CGLFTAILCC NLIENIQRLD LTPATAIKLN KYLLSLCTSY LKSEACSCRI PVDFRSTHTF LSLVHSILTS KPACMLTRKE TDHIGALILK AFLLTIPEST EERMVLGKSI IVPLKGQRVT DSTVLPGLLI EASEVQLRRL LPTQKASGLR VALFCTSLSG DFSNAGEGVV VAHYQVSLEN AVLEQLLNLG RRLVTDHVDL VLCQKVIHPS LKQFFSERHV MAIDRVGVTL MESLSKVTGA TPIGSLNPIV STTYGSVKDV CSARFGSKHF FHLLPNEATV CTLLLCSRND TAWEELKLTC QTAMHVLQLT IKEPWVLLGG GCTETHLAAY VRHKVHHEAE AIVRDDGCTQ AKLHVAAEAF CSALESVAGS LEHDGGEILI DTKYGHLWSC QADSASVGNW SDTLSRCGCG LYNSQEELSW SVLRSTYHPF APQTCLPQAA LGSASNLTVD CFTAKLSGLQ VAVETANLIL DLSYVIEDKN
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
61,924 Da
Sequence Positions
1-570, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9JI70
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Mkks recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mkks purchase

MBS1376232 is a recombinant protein targeting Mkks. Also known as Recombinant Mouse McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Mkks). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Mkks. It may not necessarily be applicable to this product.

NCBI GI #
213688394
NCBI GeneID
59030
NCBI Accession #
NP_001135418.1
UniProt Primary Accession #
Q9JI70
UniProt Secondary Accession #
Q8BGQ3
UniProt Related Accession #
Q9JI70
GenBank Nucleotide #
NM_001141946.1
NCBI Official Full Name
McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin isoform 1
NCBI Official Synonym Full Names
McKusick-Kaufman syndrome
NCBI Official Symbol
Mkks
NCBI Official Synonym Symbols
Bbs6; AI463362; AI957237; 1300013E18Rik
UniProt Protein Name
McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin
UniProt Synonym Protein Names
Protein Bbs6 homolog
Protein Family
McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin
UniProt Gene Name
Mkks
UniProt Synonym Gene Names
Bbs6
NCBI Protein Information
McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin

NCBI Summary for Mkks

This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
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UniProt Comments for Mkks

Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis (). As part of the BBS/CCT complex plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:28753627). May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis ().
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Research Articles on Mkks

1. Three uORFs (uMKKS0, uMKKS1 and uMKKS2) are reported, and they can repress the translation of the downstream MKKS ORF. uMKKS1 and uMKKS2 are highly conserved in mammals and they encode two different mitochondrial membrane proteins respectively.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Mkks recombinant protein

 Reference Product  PubMed Publications
 Bbs2 recombinant protein  >24 publications with Mkks and Bbs2
 Bbs4 recombinant protein  >21 publications with Mkks and Bbs4
 Map2k4 recombinant protein  >8 publications with Mkks and Map2k4
 Map2k6 recombinant protein  >7 publications with Mkks and Map2k6
 Bbs10 recombinant protein  >7 publications with Mkks and Bbs10
 Bbs7 recombinant protein  >7 publications with Mkks and Bbs7
 Bbs12 recombinant protein  >6 publications with Mkks and Bbs12
 Arl6 recombinant protein  >2 publications with Mkks and Arl6
 Mapk14 recombinant protein  >1 publications with Mkks and Mapk14

Diseases associated with Mkks recombinant protein

 Disease Name  Pubmed Publications
 Bardet-Biedl Syndrome Antibodies  >43 publications with Mkks and Bardet-Biedl Syndrome
 Brain Diseases Antibodies  >41 publications with Mkks and Brain Diseases
 McKusick Kaufman syndrome Antibodies  >23 publications with Mkks and McKusick Kaufman syndrome
 Heart Defects, Congenital Antibodies  >12 publications with Mkks and Heart Defects, Congenital
 Necrosis Antibodies  >9 publications with Mkks and Necrosis
 Drug Toxicity Antibodies  >6 publications with Mkks and Drug Toxicity
 Disease Models, Animal Antibodies  >5 publications with Mkks and Disease Models, Animal
 Mental Disorders Antibodies  >4 publications with Mkks and Mental Disorders
 Edema Antibodies  >2 publications with Mkks and Edema
 Adenocarcinoma Antibodies  >2 publications with Mkks and Adenocarcinoma

Organs/Tissues associated with Mkks recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >17 publications with Mkks and Heart
 Eye Antibodies  >11 publications with Mkks and Eye
 Brain Antibodies  >11 publications with Mkks and Brain
 Kidney Antibodies  >8 publications with Mkks and Kidney
 Muscle Antibodies  >5 publications with Mkks and Muscle
 Lung Antibodies  >4 publications with Mkks and Lung
 Liver Antibodies  >2 publications with Mkks and Liver
 Bone Antibodies  >1 publications with Mkks and Bone
 Intestine Antibodies  >1 publications with Mkks and Intestine
 Prostate Antibodies  >1 publications with Mkks and Prostate
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