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NLR Family CARD Domain-Containing Protein 4 (NLRC4) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1376374

MBS1376374 is a recombinant protein targeting NLRC4. Also known as Recombinant Human NLR family CARD domain-containing protein 4 (NLRC4) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$765 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NLR family CARD domain-containing protein 4 (NLRC4), Recombinant Protein
Full Product Name
Recombinant Human NLR family CARD domain-containing protein 4 (NLRC4) , partial
Product Gene Name
NLRC4 recombinant protein
Product Synonym Gene Name
NLRC4
Sequence
TDSLGNLKNL TKLIMDNIKM NEEDAIKLAE GLKNLKKMCL FHLTHLSDIG EGMDYIVKSL SSEPCDLEEI QLVSCCLSAN AVKILAQNLH NLVKLSILDL SENYLEKDGN EALHELIDRM NVLEQLTALM LPWG
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
10,646 Da
Sequence Positions
756-889aa; partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
606831
3D Structure
ModBase 3D Structure for Q9NPP4
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NLRC4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NLRC4. It may not necessarily be applicable to this product.

NCBI GI #
312433960
NCBI GeneID
58484
NCBI Accession #
NP_001186067.1
UniProt Primary Accession #
Q9NPP4
UniProt Secondary Accession #
Q96J81; Q96J82; Q96J83; A8K9F8; B2RBQ3; B3KTF0; D6W580
UniProt Related Accession #
Q9NPP4
GenBank Nucleotide #
NM_001199138.1
NCBI Official Full Name
NLR family CARD domain-containing protein 4 isoform a
NCBI Official Synonym Full Names
NLR family CARD domain containing 4
NCBI Official Symbol
NLRC4
NCBI Official Synonym Symbols
CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1
UniProt Protein Name
NLR family CARD domain-containing protein 4
UniProt Synonym Protein Names
CARD, LRR, and NACHT-containing protein; Clan protein; Caspase recruitment domain-containing protein 12; Ice protease-activating factor; Ipaf
Protein Family
NLR family CARD domain-containing protein
UniProt Gene Name
NLRC4
UniProt Synonym Gene Names
CARD12; CLAN; CLAN1; IPAF; Clan protein; Ipaf
NCBI Protein Information
NLR family CARD domain-containing protein 4

NCBI Summary for NLRC4

This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
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UniProt Comments for NLRC4

Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.

Research Articles on NLRC4

1. mRNA expression levels of NLRP1 and NLRC4 were not altered in chronic hepatitis B patients, suggesting that these genes are not responsible for the impaired immune responses against HBV observed in these patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NLRC4 recombinant protein

 Reference Product  PubMed Publications
 CASP1 recombinant protein  >236 publications with NLRC4 and CASP1
 NLRP3 recombinant protein  >193 publications with NLRC4 and NLRP3
 NLRP1 recombinant protein  >64 publications with NLRC4 and NLRP1
 IL18 recombinant protein  >58 publications with NLRC4 and IL18
 PYCARD recombinant protein  >37 publications with NLRC4 and PYCARD
 NOD2 recombinant protein  >23 publications with NLRC4 and NOD2
 IL1B recombinant protein  >11 publications with NLRC4 and IL1B
 NLRP4 recombinant protein  >4 publications with NLRC4 and NLRP4

Pathways associated with NLRC4 recombinant protein

 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram

Diseases associated with NLRC4 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >135 publications with NLRC4 and Inflammation
 Immune System Diseases Antibodies  >33 publications with NLRC4 and Immune System Diseases
 Necrosis Antibodies  >24 publications with NLRC4 and Necrosis
 Gastrointestinal Diseases Antibodies  >20 publications with NLRC4 and Gastrointestinal Diseases
 Intestinal Diseases Antibodies  >18 publications with NLRC4 and Intestinal Diseases
 Pneumonia Antibodies  >17 publications with NLRC4 and Pneumonia
 Lung Diseases Antibodies  >14 publications with NLRC4 and Lung Diseases
 Nervous System Diseases Antibodies  >7 publications with NLRC4 and Nervous System Diseases
 Liver Diseases Antibodies  >7 publications with NLRC4 and Liver Diseases
 Hereditary Autoinflammatory Diseases Antibodies  >7 publications with NLRC4 and Hereditary Autoinflammatory Diseases

Organs/Tissues associated with NLRC4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >57 publications with NLRC4 and Blood
 Bone Marrow Antibodies  >36 publications with NLRC4 and Bone Marrow
 Liver Antibodies  >15 publications with NLRC4 and Liver
 Brain Antibodies  >10 publications with NLRC4 and Brain
 Kidney Antibodies  >4 publications with NLRC4 and Kidney
 Thymus Antibodies  >2 publications with NLRC4 and Thymus
 Bladder Antibodies  >2 publications with NLRC4 and Bladder
 Uterus Antibodies  >1 publications with NLRC4 and Uterus
 Testis Antibodies  >1 publications with NLRC4 and Testis
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