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Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 1 (CTDSP1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1377127

MBS1377127 is a recombinant protein targeting CTDSP1. Also known as Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$945 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1), Recombinant Protein
Full Product Name
Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1)
Product Gene Name
CTDSP1 recombinant protein
Product Synonym Gene Name
CTDSP1
Sequence
MDSSAVITQI SKEEARGPLR GKGDQKSAAS QKPRSRGILH SLFCCVCRDD GEALPAHSGA PLLVEENGAI PKQTPVQYLL PEAKAQDSDK ICVVIDLDET LVHSSFKPVN NADFIIPVEI DGVVHQVYVL KRPHVDEFLQ RMGELFECVL FTASLAKYAD PVADLLDKWG AFRARLFRES CVFHRGNYVK DLSRLGRDLR RVLILDNSPA SYVFHPDNAV PVASWFDNMS DTELHDLLPF FEQLSRVDDV YSVLRQPRPG S
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
29,128 Da
Sequence Positions
1-261, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605323
3D Structure
ModBase 3D Structure for Q9GZU7
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CTDSP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CTDSP1. It may not necessarily be applicable to this product.

NCBI GI #
332308973
NCBI GeneID
58190
NCBI Accession #
NP_001193807.1
UniProt Primary Accession #
Q9GZU7
UniProt Secondary Accession #
Q7Z5Q3; Q7Z5Q4; C9IYG0
UniProt Related Accession #
Q9GZU7
GenBank Nucleotide #
NM_001206878.1
NCBI Official Full Name
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 3
NCBI Official Synonym Full Names
CTD small phosphatase 1
NCBI Official Symbol
CTDSP1
NCBI Official Synonym Symbols
NIF3; SCP1; NLIIF; NLI-IF
UniProt Protein Name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
UniProt Synonym Protein Names
Nuclear LIM interactor-interacting factor 3; NLI-IF; NLI-interacting factor 3; Small C-terminal domain phosphatase 1; SCP1; Small CTD phosphatase 1
Protein Family
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase
UniProt Gene Name
CTDSP1
UniProt Synonym Gene Names
NIF3; NLIIF; SCP1; NLI-IF; NLI-interacting factor 3; SCP1; Small CTD phosphatase 1
NCBI Protein Information
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

NCBI Summary for CTDSP1

This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
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UniProt Comments for CTDSP1

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
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Research Articles on CTDSP1

1. Our results provide a novel mechanistic insight into the activation of Myc by 27-HC via transcriptional repression of PP2A, SCP1 and FBW7 to increase Myc protein stability in breast cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CTDSP1 recombinant protein

 Reference Product  PubMed Publications
 REST recombinant protein  >1 publications with CTDSP1 and REST
 MBP recombinant protein  >1 publications with CTDSP1 and MBP

Pathways associated with CTDSP1 recombinant protein

 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Regulation Of Cytoplasmic And Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Cytoplasmic And Nuclear SMAD2/3 Signaling Pathway Diagram

Diseases associated with CTDSP1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with CTDSP1 and Neoplasms
 Infertility, Male Antibodies  >3 publications with CTDSP1 and Infertility, Male
 Carcinoma, Hepatocellular Antibodies  >1 publications with CTDSP1 and Carcinoma, Hepatocellular
 Aneuploidy Antibodies  >1 publications with CTDSP1 and Aneuploidy
 Adenocarcinoma Antibodies  >1 publications with CTDSP1 and Adenocarcinoma
 Chromosome Aberrations Antibodies  >1 publications with CTDSP1 and Chromosome Aberrations
 Liver Neoplasms Antibodies  >1 publications with CTDSP1 and Liver Neoplasms
 Necrosis Antibodies  >1 publications with CTDSP1 and Necrosis

Organs/Tissues associated with CTDSP1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >3 publications with CTDSP1 and Nerve
 Blood Antibodies  >2 publications with CTDSP1 and Blood
 Brain Antibodies  >2 publications with CTDSP1 and Brain
 Lymph Antibodies  >1 publications with CTDSP1 and Lymph
 Bone Antibodies  >1 publications with CTDSP1 and Bone
 Testis Antibodies  >1 publications with CTDSP1 and Testis
 Liver Antibodies  >1 publications with CTDSP1 and Liver
 Lymph Node Antibodies  >1 publications with CTDSP1 and Lymph Node
 Prostate Antibodies  >1 publications with CTDSP1 and Prostate
 Placenta Antibodies  >1 publications with CTDSP1 and Placenta
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