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Probable Jmjc Domain-Containing Histone Demethylation Protein 2c (JMJD1C), Partial (JMJD1C) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1377579

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional… More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C), partial, Recombinant Protein
Full Product Name
Recombinant Human Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C), partial
Product Gene Name
JMJD1C recombinant protein
Product Synonym Gene Name
JMJD1C; JHDM2C; KIAA1380; TRIP8
Product Synonym Names
Probable JmjC domain-containing histone demethylation protein 2C; EC=1.14.11.-; Jumonji domain-containing protein 1C; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8
Sequence
MPARYEDLLK SLPLPEYCNP EGKFNLASHL PGFFVRPDLG PRLCSAYGVV AAKDHDIGTT NLHIEVSDVV NILVYVGIAK GNGILSKAGI LKKFEEEDLD DILRKRLKDS SEIPGALWHI YAGKDVDKIR EFLQKISKEQ GLEVLPEHDP IRDQSWYVNK KLRQRLLEEY GVRTCTLIQF LGDAIVLPAG ALHQVQNFHS CIQVTEDFVS PEHLVESFHL TQELR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
45.5 kDa
Sequence Positions
2274-2498aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
604503
3D Structure
ModBase 3D Structure for Q15652
Species
Homo sapiens (Human)
Production Note
Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for JMJD1C recombinant protein

Epigenetics and Nuclear Signaling
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of JMJD1C recombinant protein

Human JMJD1C Recombinant Protein – Cat# MBS1377579

Other Notes

Small volumes of JMJD1C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JMJD1C purchase

MBS1377579 is a recombinant protein targeting JMJD1C. Also known as Recombinant Human Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for JMJD1C. It may not necessarily be applicable to this product.

NCBI GI #
545479072
NCBI GeneID
221037
NCBI Accession #
NP_001269877.1
UniProt Primary Accession #
Q15652
UniProt Secondary Accession #
Q5SQZ8; Q5SQZ9; Q5SR00; Q7Z3E7; Q8N3U0; Q96KB9; Q9P2G7; A0T124
UniProt Related Accession #
Q15652
GenBank Nucleotide #
NM_001282948.1
NCBI Official Full Name
probable JmjC domain-containing histone demethylation protein 2C isoform c
NCBI Official Synonym Full Names
jumonji domain containing 1C
NCBI Official Symbol
JMJD1C
NCBI Official Synonym Symbols
TRIP8
UniProt Protein Name
Probable JmjC domain-containing histone demethylation protein 2C
UniProt Synonym Protein Names
Jumonji domain-containing protein 1C; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8
Protein Family
Probable JmjC domain-containing histone demethylation protein
UniProt Gene Name
JMJD1C
UniProt Synonym Gene Names
JHDM2C; KIAA1380; TRIP8; TR-interacting protein 8; TRIP-8
UniProt Entry Name
JHD2C_HUMAN
NCBI Protein Information
probable JmjC domain-containing histone demethylation protein 2C; TRIP-8; TR-interacting protein 8; jumonji domain-containing protein 1C; thyroid hormone receptor interactor 8; thyroid receptor interacting protein 8; thyroid receptor-interacting protein 8

UniProt Comments for JMJD1C

TRIP8: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Belongs to the JHDM2 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Oxidoreductase; Demethylase; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: nucleoplasm; intracellular

Molecular Function: protein binding; dioxygenase activity; metal ion binding; thyroid hormone receptor binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin modification; blood coagulation
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Research Articles on JMJD1C

1. Depletion of JMJD1C impairs expansion and colony formation of leukemic cell lines, with the strongest effect observed in the MLL-rearranged ALL cell line SEM.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with JMJD1C recombinant protein

 Reference Product  PubMed Publications
 DPF3 recombinant protein  >1 publications with JMJD1C and DPF3

Pathways associated with JMJD1C recombinant protein

 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with JMJD1C recombinant protein

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >1 publications with JMJD1C and Brain Diseases
 Heart Diseases Antibodies  >1 publications with JMJD1C and Heart Diseases
 Mental Disorders Antibodies  >1 publications with JMJD1C and Mental Disorders
 Liver Diseases Antibodies  >1 publications with JMJD1C and Liver Diseases
 Cognition Disorders Antibodies  >1 publications with JMJD1C and Cognition Disorders
 Inflammation Antibodies  >1 publications with JMJD1C and Inflammation
 Nervous System Diseases Antibodies  >1 publications with JMJD1C and Nervous System Diseases
 Autistic Disorder Antibodies  >1 publications with JMJD1C and Autistic Disorder

Organs/Tissues associated with JMJD1C recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with JMJD1C and Blood
 Heart Antibodies  >6 publications with JMJD1C and Heart
 Brain Antibodies  >4 publications with JMJD1C and Brain
 Muscle Antibodies  >3 publications with JMJD1C and Muscle
 Thyroid Antibodies  >2 publications with JMJD1C and Thyroid
 Testis Antibodies  >2 publications with JMJD1C and Testis
 Liver Antibodies  >2 publications with JMJD1C and Liver
 Prostate Antibodies  >2 publications with JMJD1C and Prostate
 Intestine Antibodies  >1 publications with JMJD1C and Intestine
 Lung Antibodies  >1 publications with JMJD1C and Lung
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