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Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1377787

This protein is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from… More details

$1415 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tyrosyl-DNA phosphodiesterase 1 (Tdp1), Recombinant Protein
Full Product Name
Recombinant Mouse Tyrosyl-DNA phosphodiesterase 1 (Tdp1)
Product Gene Name
Tdp1 recombinant protein
Product Synonym Gene Name
Tdp1
Sequence
MSQESSYGKW TISSSDESED EKPKPDKPSA SSHPQAGQGV SKELIYTCSE ARKVAHKRQI SPVKFNDADS VLPHKKQKSD SPEGLGWCLS SSDDDQQPDV TQQEQPKRVL PQEKKHVSSP DVTTAQKVVD RSPPASLRPQ RADDEYETSG EGQDIWDMLD KGNPFQFYLT RVSGIKAKYN SKALHIKDIL SPLFGTLVSS AQFNYCFDVD WLIKQYPPEF RKNPILLVHG DKREAKADLH AQAKPYANIS LCQAKLDIAF GTHHTKMMLL LYEEGLRVVI HTSNLIREDW HQKTQGIWLS PLYPRIDQGS HTAGESSTRF KADLTSYLTA YNAPPLQEWI DIIQEHDLSE TNVYLIGSTP GRFQGSHRDN WGHFRLRKLL QAHAPSTPKG ECWPIVGQFS SIGSLGPDES KWLCSEFKDS LLALREEGRP PGKSAVPLHL IYPSVENVRT SLEGYPAGGS LPYSIQTAEK QRWLHSYFHK WSAETSGRSN AMPHIKTYMR PSPDFSKLAW FLVTSANLSK AAWGALEKNG TQLMIRSYEL GVLFLPSAFG LDTFKVKQKF FSSSCEPTAS FPVPYDLPPE LYRSKDRPWI WNIPYVKAPD THGNMWVPS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
68,689 Da
Sequence Positions
1-609, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8BJ37
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tdp1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tdp1 purchase

MBS1377787 is a recombinant protein targeting Tdp1. Also known as Recombinant Mouse Tyrosyl-DNA phosphodiesterase 1 (Tdp1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Tdp1. It may not necessarily be applicable to this product.

NCBI GI #
37999670
NCBI GeneID
104884
NCBI Accession #
Q8BJ37.2
UniProt Primary Accession #
Q8BJ37
UniProt Secondary Accession #
Q8VE39
UniProt Related Accession #
Q8BJ37
NCBI Official Full Name
Tyrosyl-DNA phosphodiesterase 1
NCBI Official Synonym Full Names
tyrosyl-DNA phosphodiesterase 1
NCBI Official Symbol
Tdp1
NCBI Official Synonym Symbols
SCAN1; MLZ-501; AI838772; AW493413; 2810481F14Rik; 4921509N21Rik; E430034L06Rik
UniProt Protein Name
Tyrosyl-DNA phosphodiesterase 1
UniProt Synonym Protein Names
Protein expressed in male leptotene and zygotene spermatocytes 501; MLZ-501
Protein Family
Tyrosyl-DNA phosphodiesterase
UniProt Gene Name
Tdp1
UniProt Synonym Gene Names
Tyr-DNA phosphodiesterase 1; MLZ-501
NCBI Protein Information
tyrosyl-DNA phosphodiesterase 1

UniProt Comments for Tdp1

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate ().
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Research Articles on Tdp1

1. These findings provide evidence for TDP1 as a novel mitochondrial enzyme.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Tdp1 recombinant protein

 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with Tdp1 and FLNA

Pathways associated with Tdp1 recombinant protein

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Organs/Tissues associated with Tdp1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >1 publications with Tdp1 and Thymus
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