Rat DLG3 Recombinant Protein – Cat# MBS1380297

Disks Large Homolog 3 (DLG3) Rat Recombinant Protein

Name: DLG3 Recombinant Protein; Disks Large Homolog 3; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS1380297
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1380297

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Disks large homolog 3 (Dlg3), Recombinant Protein

Full Product Name

Recombinant Rat Disks large homolog 3

Product Gene Name

Dlg3 recombinant protein

Product Synonym Names

PSD-95/SAP90-related protein 1; Synapse-associated protein 102; SAP-102; SAP102

Sequence

MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PSGGNGASSG YGGYSSQTLP SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKNTPKLNG SGPSWWPECT CTNRDWYEQA SPAPLLVNPE ALEPSLSVNG SDGMFKYEEI VLERGNSGLG FSIAGGIDNP HVPDDPGIFI TKIIPGGAAA MDGRLGVNDC VLRVNEVDVS EVVHSRAVEA LKEAGPVVRL VVRRRQPPPE TIMEVNLLKG PKGLGFSIAG GIGNQHIPGD NSIYITKIIE GGAAQKDGRL QIGDRLLAVN NTNLQDVRHE EAVASLKNTS DMVYLKVAKP GSLHLNDMYA PPDYASTFTA LADNHISHNS SLGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR EPRKIILHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL SGELRRGDRI LSVNGVNLRN ATHEQAAAAL KRAGQSVTIV AQYRPEEYSR FESKIHDLRE QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS QGLSFSYGDI LHVINASDDE WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA RTGMIESNRD FPGLSDDYYG AKNLKGVTSN TSDSESSSKG QEDAILSYEP VTRQEIHYAR PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRDNEV DGQDYHFVVS REQMEKDIQD NKFIEAGQFN DNLYGTSIQS VRAVAERGKH CILDVSGNAI KRLQQAQLYP IAIFIKPKSI EALMEMNRRQ TYEQANKIFD KAMKLEQEFG EYFTAIVQGD SLEEIYNKIK QIIEDQSGHY IWVPSPEKL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

120.5 kDa

Sequence Positions

1-849aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for Q62936

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for Dlg3 recombinant protein

SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo.Mueller B.M., Kistner U., Kindler S., Chung W.J., Kuhlendahl S., Fenster S.D., Lau L.-F., Veh R.W., Huganir R.L., Gundelfinger E.D., Garner C.C.Neuron 17:255-265(1996) SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.Takeuchi M., Hata Y., Hirao K., Toyoda A., Irie M., Takai Y.J. Biol. Chem. 272:11943-11951(1997) SynGAP a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.Kim J.H., Liao D., Lau L.-F., Huganir R.L.Neuron 20:683-691(1998) A novel family of adhesion-like molecules that interacts with the NMDA receptor.Wang C.Y., Chang K., Petralia R.S., Wang Y.X., Seabold G.K., Wenthold R.J.J. Neurosci. 26:2174-2183(2006) Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.Lee H.W., Choi J., Shin H., Kim K., Yang J., Na M., Choi S.Y., Kang G.B., Eom S.H., Kim H., Kim E.J. Neurosci. 28:14546-14556(2008)

Other Notes

Small volumes of Dlg3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dlg3 purchase

MBS1380297 is a recombinant protein targeting Dlg3. Also known as Recombinant Rat Disks large homolog 3. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Dlg3. It may not necessarily be applicable to this product.

NCBI GI #

13928878

NCBI GeneID

58948

NCBI Accession #

NP_113827.1

UniProt Primary Accession #

Q62936

UniProt Secondary Accession #

P70547

UniProt Related Accession #

Q62936

GenBank Nucleotide #

NM_031639.1

NCBI Official Full Name

disks large homolog 3

NCBI Official Synonym Full Names

discs large homolog 3

NCBI Official Symbol

Dlg3

NCBI Official Synonym Symbols

Dlgh3

UniProt Protein Name

Disks large homolog 3

UniProt Synonym Protein Names

PSD-95/SAP90-related protein 1; Synapse-associated protein 102; SAP-102; SAP102

Protein Family

Disks large

UniProt Gene Name

Dlg3

UniProt Synonym Gene Names

Dlgh3; SAP-102; SAP102

UniProt Entry Name

DLG3_RAT

NCBI Protein Information

disks large homolog 3

NCBI Summary for Dlg3

human homolog is a protein with guanylate kinase activity; involved in synaptogenesis and cell proliferation [RGD, Feb 2006]

UniProt Comments for Dlg3

DLG3: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: basolateral plasma membrane; cell soma; cytoplasm; dendritic shaft; extracellular space; growth cone; intercellular junction; ionotropic glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; tight junction

Molecular Function: guanylate kinase activity; ionotropic glutamate receptor binding; kinase binding; PDZ domain binding; phosphatase binding; protein binding; protein C-terminus binding; protein domain specific binding; protein phosphatase binding; ubiquitin protein ligase binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; establishment of planar polarity; GDP metabolic process; GMP metabolic process; nervous system development; receptor clustering; synaptic transmission

Research Articles on Dlg3

1. These data shed new light on the role of SAP102 in the regulation of NMDAR trafficking.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Dlg3 recombinant protein

Reference Product	PubMed Publications
Dlg1 recombinant protein	>15 publications with Dlg3 and Dlg1
Dlg4 recombinant protein	>12 publications with Dlg3 and Dlg4
Fmr1 recombinant protein	>1 publications with Dlg3 and Fmr1

Pathways associated with Dlg3 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of Ca-permeable Kainate Receptor Pathway antibodies	Activation Of Ca-permeable Kainate Receptor Pathway Diagram
Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies	Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Ionotropic Activity Of Kainate Receptors Pathway antibodies	Ionotropic Activity Of Kainate Receptors Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
Transmission Across Chemical Synapses Pathway antibodies	Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with Dlg3 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>14 publications with Dlg3 and Nervous System Diseases
Neurobehavioral Manifestations Antibodies	>9 publications with Dlg3 and Neurobehavioral Manifestations
Mental Retardation, X-Linked Antibodies	>8 publications with Dlg3 and Mental Retardation, X-Linked
Cell Transformation, Neoplastic Antibodies	>2 publications with Dlg3 and Cell Transformation, Neoplastic
Adenocarcinoma Antibodies	>1 publications with Dlg3 and Adenocarcinoma
Breast Neoplasms Antibodies	>1 publications with Dlg3 and Breast Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with Dlg3 and Neoplasms, Experimental
Kidney Neoplasms Antibodies	>1 publications with Dlg3 and Kidney Neoplasms
Learning Disorders Antibodies	>1 publications with Dlg3 and Learning Disorders
Neoplasm Metastasis Antibodies	>1 publications with Dlg3 and Neoplasm Metastasis

Organs/Tissues associated with Dlg3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>32 publications with Dlg3 and Brain
Kidney Antibodies	>8 publications with Dlg3 and Kidney
Lung Antibodies	>5 publications with Dlg3 and Lung
Heart Antibodies	>2 publications with Dlg3 and Heart
Testis Antibodies	>1 publications with Dlg3 and Testis
Prostate Antibodies	>1 publications with Dlg3 and Prostate