Flightless-1 Homolog (FLII) Recombinant Protein

May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Essential for early embryonic development. May play a role in regulation of cytoskeletal rearrangents involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.

Fliih, the murine homologue of the Drosophila melanogaster flightless I gene nucleotide sequence, chromosomal mapping and overlap with Llglh.Campbell H.D., Fountain S., Young I.G., Weitz S., Lichter P., Hoheisel J.D.DNA Seq. 11:29-40(2000) Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) The flightless I protein localizes to actin-based structures during embryonic development.Davy D.A., Ball E.E., Matthaei K.I., Campbell H.D., Crouch M.F.Immunol. Cell Biol. 78:423-429(2000) Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development.Campbell H.D., Fountain S., McLennan I.S., Berven L.A., Crouch M.F., Davy D.A., Hooper J.A., Waterford K., Chen K.-S., Lupski J.R., Ledermann B., Young I.G., Matthaei K.I.Mol. Cell. Biol. 22:3518-3526(2002) Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity.Lee Y.-H., Campbell H.D., Stallcup M.R.Mol. Cell. Biol. 24:2103-2117(2004) The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts evidence for the involvement of PI 3-kinase and Ras-related small GTPases.Davy D.A., Campbell H.D., Fountain S., de Jong D., Crouch M.F.J. Cell Sci. 114:549-562(2001) Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway.Kopecki Z., O'Neill G.M., Arkell R.M., Cowin A.J.J. Invest. Dermatol. 131:1450-1459(2011) Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration.Mohammad I., Arora P.D., Naghibzadeh Y., Wang Y., Li J., Mascarenhas W., Janmey P.A., Dawson J.F., McCulloch C.A.FASEB J. 26:3260-3272(2012)

Small volumes of Flii recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1380498 is a recombinant protein targeting Flii. Also known as Recombinant Mouse Protein flightless-1 homolog. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.