Sushi Repeat-Containing Protein SRPX2 (SRPX2) Mouse Recombinant Protein

SRPX2: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion in cancer cells. Increases the phosphorylation levels of FAK. May have a role in the perisylvian region, critical for language and cognitive development. Defects in SRPX2 are a cause of bilateral perisylvian polymicrogyria (BPP). BPP is the most common form of polymicrogyria, a malformation of the cortex, in which the brain surface is irregular and the normal gyral pattern replaced by multiple small, partly fused, gyri separated by shallow sulci. BPP results in mild mental retardation, epilepsy and pseudobulbar palsy, causing difficulties with expressive speech and feeding. Defects in SRPX2 are a cause of rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX). A condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and mental retardation. Rolandic occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; cell surface; cytoplasm; extracellular region; excitatory synapse; synapse; cell junction

Molecular Function: identical protein binding; receptor binding

Biological Process: positive regulation of synaptogenesis; cell-cell adhesion; regulation of phosphorylation; cell motility involved in cell locomotion; angiogenesis; cell adhesion