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Polyadenylate-Binding Protein 2 (PABPN1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1382327

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails on the 3 ends of eukaryotic genes and controls the size of the poly(A)… More details

$990 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Polyadenylate-binding protein 2 (Pabpn1), Recombinant Protein
Full Product Name
Recombinant Mouse Polyadenylate-binding protein 2 (Pabpn1)
Product Gene Name
Pabpn1 recombinant protein
Product Synonym Gene Name
Pabpn1
Sequence
AAAAAAAAAA GAAGGRGSGP GRRRHLVPGA GGEAGEGDPG GAGDYGNGLE SEELEPGELL PEPEPEEEPP RPRAPPGAPG PGPGSGAPGS QEEEEEPGLV EADPGDGAIE DPELEAIKAR VREMEEEAEK LKELQNEVEK QMNMSPPPGN AGPVIMSLEE KMEADARSIY VGNVDYGATA EELEAHFHGC GSVNRVTILC DKFSGHPKGF AYIEFSDKES VRTSLALDES LFRGRQIKVI PKRTNRPGIS TTDRGFPRSR YRARTTNYNS SRSRFYSGFN SRPRGRIYRG RARATSWYSP Y
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
31,044 Da
Sequence Positions
2-302, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8CCS6
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Pabpn1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pabpn1 purchase

MBS1382327 is a recombinant protein targeting Pabpn1. Also known as Recombinant Mouse Polyadenylate-binding protein 2 (Pabpn1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Pabpn1. It may not necessarily be applicable to this product.

NCBI GI #
9506945
NCBI GeneID
54196
NCBI Accession #
NP_062275.1
UniProt Primary Accession #
Q8CCS6
UniProt Secondary Accession #
O35935
UniProt Related Accession #
Q8CCS6
GenBank Nucleotide #
NM_019402.2
NCBI Official Full Name
polyadenylate-binding protein 2
NCBI Official Synonym Full Names
poly(A) binding protein, nuclear 1
NCBI Official Symbol
Pabpn1
NCBI Official Synonym Symbols
PAB2; Pabp3; mPABII
UniProt Protein Name
Polyadenylate-binding protein 2
UniProt Synonym Protein Names
Nuclear poly(A)-binding protein 1; Poly(A)-binding protein II; PABII; Polyadenylate-binding nuclear protein 1
UniProt Gene Name
Pabpn1
UniProt Synonym Gene Names
Pab2; Pabp2; PABP-2; Poly(A)-binding protein 2; PABII
NCBI Protein Information
polyadenylate-binding protein 2

UniProt Comments for Pabpn1

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters ().
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Research Articles on Pabpn1

1. Matrin 3 (MATR3) is a novel protein interactor of PABPN1. MATR3 also binds and regulates the levels of long non-coding RNA (lncRNA) Neat1 and together with PABPN1 is required for normal paraspeckle function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Pabpn1 recombinant protein

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 Processing Of Capped Intronless Pre-mRNA Pathway antibodies  Processing Of Capped Intronless Pre-mRNA Pathway Diagram
 Processing Of Intronless Pre-mRNAs Pathway antibodies  Processing Of Intronless Pre-mRNAs Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram

Diseases associated with Pabpn1 recombinant protein

 Disease Name  Pubmed Publications
 Muscular Dystrophy, Oculopharyngeal Antibodies  >86 publications with Pabpn1 and Muscular Dystrophy, Oculopharyngeal
 Nervous System Diseases Antibodies  >71 publications with Pabpn1 and Nervous System Diseases
 Drug Toxicity Antibodies  >7 publications with Pabpn1 and Drug Toxicity
 Mental Disorders Antibodies  >2 publications with Pabpn1 and Mental Disorders
 Brain Diseases Antibodies  >2 publications with Pabpn1 and Brain Diseases
 Atrophy Antibodies  >2 publications with Pabpn1 and Atrophy
 Prostatic Neoplasms Antibodies  >1 publications with Pabpn1 and Prostatic Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with Pabpn1 and Congenital Abnormalities
 Neoplasms Antibodies  >1 publications with Pabpn1 and Neoplasms
 Prostatic Diseases Antibodies  >1 publications with Pabpn1 and Prostatic Diseases

Organs/Tissues associated with Pabpn1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >62 publications with Pabpn1 and Muscle
 Brain Antibodies  >8 publications with Pabpn1 and Brain
 Eye Antibodies  >6 publications with Pabpn1 and Eye
 Dorsal Root Ganglion Antibodies  >1 publications with Pabpn1 and Dorsal Root Ganglion
 Heart Antibodies  >1 publications with Pabpn1 and Heart
 Prostate Antibodies  >1 publications with Pabpn1 and Prostate
 Tongue Antibodies  >1 publications with Pabpn1 and Tongue
 Ovary Antibodies  >1 publications with Pabpn1 and Ovary
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