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Rho-Associated Protein Kinase 2 (ROCK2) Bovine Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1384725

This protein is a serinethreonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a… More details

$945 / 0.05 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rho-associated protein kinase 2 (ROCK2), Recombinant Protein
Full Product Name
Recombinant Bovine Rho-associated protein kinase 2 (ROCK2) , partial
Product Gene Name
ROCK2 recombinant protein
Product Synonym Gene Name
ROCK2
Sequence
YDVVKVIGRG AFGEVQLVRH KASQKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW VVQLFCAFQD DKYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI HRDVKPDNML LDKHGHLKLA DFGTCMKMDE TGMVHCDTAV GTPDYISPEV LKSQGGDGYY GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLCFPEDAEI SKHAKNLICA FLTDREVRLG RNGVEEIKQH PFF
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
160,800 Da
Sequence Positions
92-354. Partial, provide the Protein kinase Domain.
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q28021
Species
Bovine
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ROCK2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ROCK2 purchase

MBS1384725 is a recombinant protein targeting ROCK2. Also known as Recombinant Bovine Rho-associated protein kinase 2 (ROCK2) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ROCK2. It may not necessarily be applicable to this product.

NCBI GI #
27806123
NCBI GeneID
282041
NCBI Accession #
NP_776877.1
UniProt Primary Accession #
Q28021
UniProt Related Accession #
Q28021
GenBank Nucleotide #
NM_174452.2
NCBI Official Full Name
rho-associated protein kinase 2
NCBI Official Synonym Full Names
Rho associated coiled-coil containing protein kinase 2
NCBI Official Symbol
ROCK2
NCBI Official Synonym Symbols
ROCK-II
UniProt Protein Name
Rho-associated protein kinase 2
UniProt Synonym Protein Names
Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; ROCK-II; p164 ROCK-2
Protein Family
Rho-associated protein kinase
UniProt Gene Name
ROCK2
UniProt Synonym Gene Names
ROCK-II
NCBI Protein Information
rho-associated protein kinase 2

UniProt Comments for ROCK2

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca2+ sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
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Research Articles on ROCK2

1. Rho-kinase analysis of coiled-coil association of the RhoA-binding domain

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ROCK2 recombinant protein

 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with ROCK2 and FLNA

Pathways associated with ROCK2 recombinant protein

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram

Diseases associated with ROCK2 recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >65 publications with ROCK2 and Cardiovascular Diseases
 Hypertension Antibodies  >42 publications with ROCK2 and Hypertension
 Disease Models, Animal Antibodies  >38 publications with ROCK2 and Disease Models, Animal
 Inflammation Antibodies  >27 publications with ROCK2 and Inflammation
 Nervous System Diseases Antibodies  >25 publications with ROCK2 and Nervous System Diseases
 Brain Diseases Antibodies  >17 publications with ROCK2 and Brain Diseases
 Fibrosis Antibodies  >15 publications with ROCK2 and Fibrosis
 Neoplasm Metastasis Antibodies  >13 publications with ROCK2 and Neoplasm Metastasis
 Atherosclerosis Antibodies  >11 publications with ROCK2 and Atherosclerosis
 Breast Neoplasms Antibodies  >11 publications with ROCK2 and Breast Neoplasms

Organs/Tissues associated with ROCK2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >45 publications with ROCK2 and Muscle
 Lung Antibodies  >16 publications with ROCK2 and Lung
 Brain Antibodies  >12 publications with ROCK2 and Brain
 Kidney Antibodies  >7 publications with ROCK2 and Kidney
 Liver Antibodies  >6 publications with ROCK2 and Liver
 Skin Antibodies  >4 publications with ROCK2 and Skin
 Intestine Antibodies  >3 publications with ROCK2 and Intestine
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