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Rap Guanine Nucleotide Exchange Factor 5 (RAPGEF5) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1385152

MBS1385152 is a recombinant protein targeting RAPGEF5. Also known as Recombinant Human Rap guanine nucleotide exchange factor 5 (RAPGEF5). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1370 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rap guanine nucleotide exchange factor 5 (RAPGEF5), Recombinant Protein
Full Product Name
Recombinant Human Rap guanine nucleotide exchange factor 5 (RAPGEF5)
Product Gene Name
RAPGEF5 recombinant protein
Product Synonym Gene Name
RAPGEF5
Sequence
MGSSRLRVFD PHLERKDSAA ALSDRELPLP TFDVPYFKYI DEEDEDDEWS SRSQSSTEDD SVDSLLSDRY VVVSGTPEKI LEHLLNDLHL EEVQDKETET LLDDFLLTYT VFMTTDDLCQ ALLRHYSAKK YQGKEENSDV PRRKRKVLHL VSQWIALYKD WLPEDEHSKM FLKTIYRNVL DDVYEYPILE KELKEFQKIL GMHRRHTVDE YSPQKKNKAL FHQFSLKENW LQHRGTVTET EEIFCHVYIT EHSYVSVKAK VSSIAQEILK VVAEKIQYAE EDLALVAITF SGEKHELQPN DLVISKSLEA SGRIYVYRKD LADTLNPFAE NEESQQRSMR ILGMNTWDLA LELMNFDWSL FNSIHEQELI YFTFSRQGSG EHTANLSLLL QRCNEVQLWV ATEILLCSQL GKRVQLVKKF IKIAAHCKAQ RNLNSFFAIV MGLNTASVSR LSQTWEKIPG KFKKLFSELE SLTDPSLNHK AYRDAFKKMK PPKIPFMPLL LKDVTFIHEG NKTFLDNLVN FEKLHMIADT VRTLRHCRTN QFGDLSPKEH QELKSYVNHL YVIDSQQALF ELSHRIEPRV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
52,083 Da
Sequence Positions
1-580, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
609527
3D Structure
ModBase 3D Structure for Q92565
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RAPGEF5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RAPGEF5. It may not necessarily be applicable to this product.

NCBI GI #
119392077
NCBI GeneID
9771
NCBI Accession #
NP_036426.3
UniProt Primary Accession #
Q92565
UniProt Secondary Accession #
Q8IXU5; A4D140
UniProt Related Accession #
Q92565
GenBank Nucleotide #
NM_012294.3
NCBI Official Full Name
rap guanine nucleotide exchange factor 5
NCBI Official Synonym Full Names
Rap guanine nucleotide exchange factor 5
NCBI Official Symbol
RAPGEF5
NCBI Official Synonym Symbols
GFR; REPAC; MR-GEF
UniProt Protein Name
Rap guanine nucleotide exchange factor 5
UniProt Synonym Protein Names
Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac
Protein Family
Rap guanine nucleotide exchange factor
UniProt Gene Name
RAPGEF5
UniProt Synonym Gene Names
GFR; KIAA0277; MRGEF; MR-GEF; Repac
NCBI Protein Information
rap guanine nucleotide exchange factor 5

NCBI Summary for RAPGEF5

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
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UniProt Comments for RAPGEF5

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.

Research Articles on RAPGEF5

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RAPGEF5 recombinant protein

 Reference Product  PubMed Publications
 RAP2B recombinant protein  >1 publications with RAPGEF5 and RAP2B
 RAP2A recombinant protein  >1 publications with RAPGEF5 and RAP2A
 RAP1A recombinant protein  >1 publications with RAPGEF5 and RAP1A

Pathways associated with RAPGEF5 recombinant protein

 Products by Pathway  Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram

Diseases associated with RAPGEF5 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with RAPGEF5 and Neoplasms
 Lung Neoplasms Antibodies  >1 publications with RAPGEF5 and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with RAPGEF5 and Lung Diseases

Organs/Tissues associated with RAPGEF5 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with RAPGEF5 and Brain
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