Human RSPO3 Recombinant Protein – Cat# MBS1386730

R-Spondin-3 (RSPO3) Human Recombinant Protein

Name: RSPO3 Recombinant Protein; R-Spondin-3; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1386730
Price: 920 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1386730

This gene encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of… More details

$920 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

R-spondin-3 (RSPO3), Recombinant Protein

Full Product Name

Recombinant Human R-spondin-3 (RSPO3)

Product Gene Name

RSPO3 recombinant protein

Product Synonym Gene Name

RSPO3

Sequence

QNASRGRRQR RMHPNVSQGC QGGCATCSDY NGCLSCKPRL FFALERIGMK QIGVCLSSCP SGYYGTRYPD INKCTKCKAD CDTCFNKNFC TKCKSGFYLH LGKCLDNCPE GLEANNHTME CVSIVHCEVS EWNPWSPCTK KGKTCGFKRG TETRVREIIQ HPSAKGNLCP PTNETRKCTV QRKKCQKGER GKKGRERKRK KPNKGESKEA IPDSKSLESS KEIPEQRENK QQQKKRKVQD KQKSVSVSTV H

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

33,233 Da

Sequence Positions

22-272, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

610574

3D Structure

ModBase 3D Structure for Q9BXY4

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RSPO3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RSPO3 purchase

MBS1386730 is a recombinant protein targeting RSPO3. Also known as Recombinant Human R-spondin-3 (RSPO3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for RSPO3. It may not necessarily be applicable to this product.

NCBI GI #

18490982

NCBI GeneID

84870

NCBI Accession #

NP_116173.2

UniProt Primary Accession #

Q9BXY4

UniProt Secondary Accession #

Q5VTV4; Q96K87; B2RC27

GenBank Nucleotide #

NM_032784.4

NCBI Official Full Name

R-spondin-3

UniProt Protein Name

R-spondin-3

UniProt Synonym Protein Names

Protein with TSP type-1 repeat; hPWTSR; Roof plate-specific spondin-3; hRspo3; Thrombospondin type-1 domain-containing protein 2

Protein Family

R-spondin

UniProt Gene Name

RSPO3

UniProt Synonym Gene Names

PWTSR; THSD2; hPWTSR; hRspo3

UniProt Comments for RSPO3

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells ().

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RSPO3 recombinant protein

Reference Product	PubMed Publications
FURIN recombinant protein	>3 publications with RSPO3 and FURIN
SDC4 recombinant protein	>2 publications with RSPO3 and SDC4
LRP6 recombinant protein	>1 publications with RSPO3 and LRP6
WNT11 recombinant protein	>1 publications with RSPO3 and WNT11
MYF5 recombinant protein	>1 publications with RSPO3 and MYF5

Pathways associated with RSPO3 recombinant protein

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies	RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By WNT In Cancer Pathway antibodies	Signaling By WNT In Cancer Pathway Diagram
Signaling By Wnt Pathway antibodies	Signaling By Wnt Pathway Diagram
TCF Dependent Signaling In Response To WNT Pathway antibodies	TCF Dependent Signaling In Response To WNT Pathway Diagram
XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies	XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies	Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
Regulation Of FZD By Ubiquitination Pathway antibodies	Regulation Of FZD By Ubiquitination Pathway Diagram

Diseases associated with RSPO3 recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>3 publications with RSPO3 and Disease Models, Animal
Bone Diseases, Metabolic Antibodies	>2 publications with RSPO3 and Bone Diseases, Metabolic
Breast Neoplasms Antibodies	>1 publications with RSPO3 and Breast Neoplasms

Organs/Tissues associated with RSPO3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>5 publications with RSPO3 and Connective Tissue
Brain Antibodies	>5 publications with RSPO3 and Brain
Embryonic Tissue Antibodies	>4 publications with RSPO3 and Embryonic Tissue
Adipose Tissue Antibodies	>3 publications with RSPO3 and Adipose Tissue
Lung Antibodies	>3 publications with RSPO3 and Lung
Heart Antibodies	>3 publications with RSPO3 and Heart
Placenta Antibodies	>2 publications with RSPO3 and Placenta
Prostate Antibodies	>2 publications with RSPO3 and Prostate
Intestine Antibodies	>1 publications with RSPO3 and Intestine