Human EDA Recombinant Protein – Cat# MBS1388448

Ectodysplasin-A (EDA) Human Recombinant Protein

Name: EDA Recombinant Protein; Ectodysplasin-A; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1388448
Price: 815 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1388448

This protein is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development… More details

$815 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ectodysplasin-A (EDA), Recombinant Protein

Full Product Name

Recombinant Human Ectodysplasin-A (EDA), partial

Product Gene Name

EDA recombinant protein

Product Synonym Gene Name

EDA

Sequence

GLQGPSGAAD KAGTRENQPA VVHLQGQGSA IQVKNDLSGG VLNDWSRITM NPKVFKLHPR SGELEVLVDG TYFIYSQVEV YYINFTDFAS YEVVVDEKPF LQCTRSIETG KTNYNTCYTA GVCLLKARQK IAVKMVHADI SINMSKHTTF FGAIRLGEAP AS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

40,750 Da

Sequence Positions

230-391aa; Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

300451

3D Structure

ModBase 3D Structure for Q92838

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EDA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EDA purchase

MBS1388448 is a recombinant protein targeting EDA. Also known as Recombinant Human Ectodysplasin-A (EDA), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for EDA. It may not necessarily be applicable to this product.

NCBI GI #

54112101

NCBI GeneID

1896

NCBI Accession #

NP_001005609.1

UniProt Primary Accession #

Q92838

UniProt Secondary Accession #

O75910; Q5JS00; Q5JUM7; Q9UP77; Q9Y6L0; Q9Y6L1; Q9Y6L2; A0AUZ2; A2A337; B7ZLU2; B7ZLU4

UniProt Related Accession #

Q92838

GenBank Nucleotide #

NM_001005609.1

NCBI Official Full Name

ectodysplasin-A isoform 2

NCBI Official Synonym Full Names

ectodysplasin A

NCBI Official Symbol

EDA

NCBI Official Synonym Symbols

ED1; HED; EDA1; EDA2; HED1; ODT1; XHED; ECTD1; XLHED; ED1-A1; ED1-A2; EDA-A1; EDA-A2; TNLG7C; STHAGX1

UniProt Protein Name

Ectodysplasin-A

UniProt Synonym Protein Names

Ectodermal dysplasia protein; EDA protein

Protein Family

2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase

UniProt Gene Name

EDA

UniProt Synonym Gene Names

ED1; EDA2; EDA protein

NCBI Protein Information

ectodysplasin-A

NCBI Summary for EDA

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for EDA

Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R (PubMed:8696334, PubMed:11039935, PubMed:27144394). May also play a role in cell adhesion ().

Research Articles on EDA

1. This is the first analysis of the role of Eda in the root, showing a direct role for this pathway during postnatal mouse development, and it suggests that changes in proliferation and angle of HERS may underlie taurodontism in a range of syndromes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with EDA recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with EDA recombinant protein

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>254 publications with EDA and Congenital Abnormalities
Nervous System Diseases Antibodies	>149 publications with EDA and Nervous System Diseases
Necrosis Antibodies	>144 publications with EDA and Necrosis
Brain Diseases Antibodies	>81 publications with EDA and Brain Diseases
Heart Diseases Antibodies	>71 publications with EDA and Heart Diseases
Inflammation Antibodies	>67 publications with EDA and Inflammation
Ectodermal Dysplasia 1, Anhidrotic Antibodies	>54 publications with EDA and Ectodermal Dysplasia 1, Anhidrotic
Adenocarcinoma Antibodies	>46 publications with EDA and Adenocarcinoma
Liver Diseases Antibodies	>36 publications with EDA and Liver Diseases
Kidney Diseases Antibodies	>28 publications with EDA and Kidney Diseases

Organs/Tissues associated with EDA recombinant protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>347 publications with EDA and Skin
Brain Antibodies	>189 publications with EDA and Brain
Heart Antibodies	>163 publications with EDA and Heart
Muscle Antibodies	>119 publications with EDA and Muscle
Lung Antibodies	>84 publications with EDA and Lung
Embryonic Tissue Antibodies	>58 publications with EDA and Embryonic Tissue
Kidney Antibodies	>55 publications with EDA and Kidney
Connective Tissue Antibodies	>35 publications with EDA and Connective Tissue
Ovary Antibodies	>30 publications with EDA and Ovary
Spleen Antibodies	>14 publications with EDA and Spleen