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Cgmp-Dependent Protein Kinase 2 (PRKG2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1389282

MBS1389282 is a recombinant protein targeting PRKG2. Also known as Recombinant Human cGMP-dependent protein kinase 2 (PRKG2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1625 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
cGMP-dependent protein kinase 2 (PRKG2), Recombinant Protein
Full Product Name
Recombinant Human cGMP-dependent protein kinase 2 (PRKG2)
Product Gene Name
PRKG2 recombinant protein
Product Synonym Gene Name
PRKG2
Sequence
GNGSVKPKHS KHPDGHSGNL TTDALRNKVT ELERELRRKD AEIQEREYHL KELREQLSKQ TVAIAELTEE LQNKCIQLNK LQDVVHMQGG SPLQASPDKV PLEVHRKTSG LVSLHSRRGA KAGVSAEPTT RTYDLNKPPE FSFEKARVRK DSSEKKLITD ALNKNQFLKR LDPQQIKDMV ECMYGRNYQQ GSYIIKQGEP GNHIFVLAEG RLEVFQGEKL LSSIPMWTTF GELAILYNCT RTASVKAITN VKTWALDREV FQNIMRRTAQ ARDEQYRNFL RSVSLLKNLP EDKLTKIIDC LEVEYYDKGD YIIREGEEGS TFFILAKGKV KVTQSTEGHD QPQLIKTLQK GEYFGEKALI SDDVRSANII AEENDVACLV IDRETFNQTV GTFEELQKYL EGYVANLNRD DEKRHAKRSM SNWKLSKALS LEMIQLKEKV ARFSSSSPFQ NLEIIATLGV GGFGRVELVK VKNENVAFAM KCIRKKHIVD TKQQEHVYSE KRILEELCSP FIVKLYRTFK DNKYVYMLLE ACLGGELWSI LRDRGSFDEP TSKFCVACVT EAFDYLHRLG IIYRDLKPEN LILDAEGYLK LVDFGFAKKI GSGQKTWTFC GTPEYVAPEV ILNKGHDFSV DFWSLGILVY ELLTGNPPFS GVDQMMTYNL ILKGIEKMDF PRKITRRPED LIRRLCRQNP TERLGNLKNG INDIKKHRWL NGFNWEGLKA RSLPSPLQRE LKGPIDHSYF DKYPPEKGMP PDELSGWDKD F
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
84,398 Da
Sequence Positions
2-762, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
601591
3D Structure
ModBase 3D Structure for Q13237
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PRKG2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PRKG2. It may not necessarily be applicable to this product.

NCBI GI #
541866806
NCBI GeneID
5593
NCBI Accession #
NP_001269409.1
UniProt Primary Accession #
Q13237
UniProt Secondary Accession #
O00125; O60916; B4DMX3; E7EPE6
UniProt Related Accession #
Q13237
GenBank Nucleotide #
NM_001282480.1
NCBI Official Full Name
cGMP-dependent protein kinase 2 isoform b
NCBI Official Synonym Full Names
protein kinase, cGMP-dependent, type II
NCBI Official Symbol
PRKG2
NCBI Official Synonym Symbols
cGK2; cGKII; PRKGR2
UniProt Protein Name
cGMP-dependent protein kinase 2
UniProt Synonym Protein Names
cGMP-dependent protein kinase II; cGKII
Protein Family
cGMP-dependent protein kinase
UniProt Gene Name
PRKG2
UniProt Synonym Gene Names
PRKGR2; cGK 2; cGK2; cGKII
NCBI Protein Information
cGMP-dependent protein kinase 2

NCBI Summary for PRKG2

This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
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UniProt Comments for PRKG2

Crucial regulator of intestinal secretion and bone growth (). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation ().
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Research Articles on PRKG2

1. the results indicated that PKG II could block c-Met activation via phosphorylating Ser985

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRKG2 recombinant protein

 Reference Product  PubMed Publications
 SOX9 recombinant protein  >6 publications with PRKG2 and SOX9

Pathways associated with PRKG2 recombinant protein

 Products by Pathway  Pathway Diagram
 Ca2+ Pathway antibodies  Ca2+ Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nitric Oxide Pathway antibodies  Metabolism Of Nitric Oxide Pathway Diagram

Diseases associated with PRKG2 recombinant protein

 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >7 publications with PRKG2 and Bone Diseases
 Nervous System Diseases Antibodies  >6 publications with PRKG2 and Nervous System Diseases
 Growth Disorders Antibodies  >6 publications with PRKG2 and Growth Disorders
 Aneuploidy Antibodies  >4 publications with PRKG2 and Aneuploidy
 Cardiovascular Diseases Antibodies  >2 publications with PRKG2 and Cardiovascular Diseases
 Hypertrophy Antibodies  >2 publications with PRKG2 and Hypertrophy
 Atherosclerosis Antibodies  >1 publications with PRKG2 and Atherosclerosis
 Heart Diseases Antibodies  >1 publications with PRKG2 and Heart Diseases
 Inflammation Antibodies  >1 publications with PRKG2 and Inflammation
 Liver Neoplasms Antibodies  >1 publications with PRKG2 and Liver Neoplasms

Organs/Tissues associated with PRKG2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >1 publications with PRKG2 and Testis
 Embryonic Tissue Antibodies  >1 publications with PRKG2 and Embryonic Tissue
 Prostate Antibodies  >1 publications with PRKG2 and Prostate
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