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F-Box/LRR-Repeat Protein 7 (FBXL7) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1389463

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which… More details

$1290 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
F-box/LRR-repeat protein 7 (FBXL7), Recombinant Protein
Full Product Name
Recombinant Human F-box/LRR-repeat protein 7 (FBXL7)
Product Gene Name
FBXL7 recombinant protein
Product Synonym Gene Name
FBXL7
Sequence
MGANNGKQYG SEGKGSSSIS SDVSSSTDHT PTKAQKNVAT SEDSDLSMRT LSTPSPALIC PPNLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL IRLASRPQKE QASIDRLPDH SMVQIFSFLP TNQLCRCARV CRRWYNLAWD PRLWRTIRLT GETINVDRAL KVLTRRLCQD TPNVCLMLET VTVSGCRRLT DRGLYTIAQC CPELRRLEVS GCYNISNEAV FDVVSLCPNL EHLDVSGCSK VTCISLTREA SIKLSPLHGK QISIRYLDMT DCFVLEDEGL HTIAAHCTQL THLYLRRCVR LTDEGLRYLV IYCASIKELS VSDCRFVSDF GLREIAKLES RLRYLSIAHC GRVTDVGIRY VAKYCSKLRY LNARGCEGIT DHGVEYLAKN CTKLKSLDIG KCPLVSDTGL ECLALNCFNL KRLSLKSCES ITGQGLQIVA ANCFDLQTLN VQDCEVSVEA LRFVKRHCKR CVIEHTNPAF F
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
49,844 Da
Sequence Positions
1-491, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605656
3D Structure
ModBase 3D Structure for Q9UJT9
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FBXL7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FBXL7 purchase

MBS1389463 is a recombinant protein targeting FBXL7. Also known as Recombinant Human F-box/LRR-repeat protein 7 (FBXL7). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for FBXL7. It may not necessarily be applicable to this product.

NCBI GI #
508083038
NCBI GeneID
23194
NCBI Accession #
NP_001265246.1
UniProt Primary Accession #
Q9UJT9
UniProt Secondary Accession #
O94926; B9EGF1; D6RDY7
UniProt Related Accession #
Q9UJT9
GenBank Nucleotide #
NM_001278317.1
NCBI Official Full Name
F-box/LRR-repeat protein 7 isoform 2
NCBI Official Synonym Full Names
F-box and leucine rich repeat protein 7
NCBI Official Symbol
FBXL7
NCBI Official Synonym Symbols
FBL6; FBL7
UniProt Protein Name
F-box/LRR-repeat protein 7
UniProt Synonym Protein Names
F-box and leucine-rich repeat protein 7; F-box protein FBL6/FBL7
Protein Family
F-box/LRR-repeat protein
UniProt Gene Name
FBXL7
UniProt Synonym Gene Names
FBL6; FBL7; KIAA0840
NCBI Protein Information
F-box/LRR-repeat protein 7

NCBI Summary for FBXL7

This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
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UniProt Comments for FBXL7

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.

Research Articles on FBXL7

1. Fbxl18 regulates apoptosis by mediating ubiquitin-dependent proteasomal degradation of the pro-apoptotic protein Fbxl7 that may impact cellular processes involved in cell cycle progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with FBXL7 recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >1 publications with FBXL7 and Carcinoma
 Breast Neoplasms Antibodies  >1 publications with FBXL7 and Breast Neoplasms
 Skin Diseases Antibodies  >1 publications with FBXL7 and Skin Diseases
 Neoplasms Antibodies  >1 publications with FBXL7 and Neoplasms

Organs/Tissues associated with FBXL7 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with FBXL7 and Lung
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