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F-Box/Wd Repeat-Containing Protein 11 (FBXW11) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1389644

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which… More details

$1155 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
F-box/WD repeat-containing protein 11 (Fbxw11), Recombinant Protein
Full Product Name
Recombinant Mouse F-box/WD repeat-containing protein 11 (Fbxw11)
Product Gene Name
Fbxw11 recombinant protein
Product Synonym Gene Name
Fbxw11
Sequence
MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQI SNGTSSVIVS RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE FVEHLISRMC HYQHGHINSY LKPMLQRDFI TALPEQGLDH IAENILSYLD ARSLCAAELV CKEWQRVISE GMLWKKLIER MVRTDPLWKG LSERRGWDQY LFKNRPTDGP PNSFYRSLYP KIIQDIETIE SNWRCGRHNL QRIQCRSENS KGVYCLQYDD DKIISGLRDN SIKIWDKSSL ECLKVLTGHT GSVLCLQYDE RVIVTGSSDS TVRVWDVNTG EVLNTLIHHN EAVLHLRFSN GLMVTCSKDR SIAVWDMASA TDITLRRVLV GHRAAVNVVD FDDKYIVSAS GDRTIKVWST STCEFVRTLN GHKRGIACLQ YRDRLVVSGS SDNTIRLWDI ECGACLRVLE GHEELVRCIR FDNKRIVSGA YDGKIKVWDL QAALDPRAPA STLCLRTLVE HSGRVFRLQF DEFQIISSSH DDTILIWDFL NVPPSAQNET RSPSRTYTYI SR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
58,394 Da
Sequence Positions
1-542aa, Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q5SRY7
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Fbxw11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Fbxw11 purchase

MBS1389644 is a recombinant protein targeting Fbxw11. Also known as Recombinant Mouse F-box/WD repeat-containing protein 11 (Fbxw11). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Fbxw11. It may not necessarily be applicable to this product.

NCBI GI #
405778325
NCBI GeneID
103583
NCBI Accession #
NP_001258276.1
UniProt Primary Accession #
Q5SRY7
UniProt Secondary Accession #
Q3TGM9; Q3TLZ8; Q8BY90; Q8K022; Q923H0
UniProt Related Accession #
Q5SRY7
GenBank Nucleotide #
NM_001271347.1
NCBI Official Full Name
F-box/WD repeat-containing protein 11 isoform b
NCBI Official Synonym Full Names
F-box and WD-40 domain protein 11
NCBI Official Symbol
Fbxw11
NCBI Official Synonym Symbols
HOS; BTRC2; BTRCP2; Fbxw1b; AA536858; 2310065A07Rik
UniProt Protein Name
F-box/WD repeat-containing protein 11
UniProt Synonym Protein Names
F-box and WD repeats protein beta-TrCP2; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein; HOS
Protein Family
F-box/WD repeat-containing protein
UniProt Gene Name
Fbxw11
UniProt Synonym Gene Names
Btrcp2; Fbw1b; Fbxw1b; HOS
NCBI Protein Information
F-box/WD repeat-containing protein 11

UniProt Comments for Fbxw11

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
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Research Articles on Fbxw11

1. The mTOR pathway promotes cell proliferation via beta-TrCP2-dependent p19(Arf) degradation under nutrient-rich conditions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Fbxw11 recombinant protein

 Reference Product  PubMed Publications
 Ctnnb1 recombinant protein  >11 publications with Fbxw11 and Ctnnb1
 Cul1 recombinant protein  >4 publications with Fbxw11 and Cul1
 Gli3 recombinant protein  >3 publications with Fbxw11 and Gli3
 Gli2 recombinant protein  >2 publications with Fbxw11 and Gli2
 Skp2 recombinant protein  >2 publications with Fbxw11 and Skp2

Pathways associated with Fbxw11 recombinant protein

 Products by Pathway  Pathway Diagram
 Circadian Rhythm - Mammal Pathway antibodies  Circadian Rhythm - Mammal Pathway Diagram
 Circadian Rhythm - Mammal Pathway antibodies  Circadian Rhythm - Mammal Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Oocyte Meiosis Pathway antibodies  Oocyte Meiosis Pathway Diagram
 Oocyte Meiosis Pathway antibodies  Oocyte Meiosis Pathway Diagram
 SCF-BTRC Complex Pathway antibodies  SCF-BTRC Complex Pathway Diagram
 TNF-alpha NF-kB Signaling Pathway antibodies  TNF-alpha NF-kB Signaling Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with Fbxw11 recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >5 publications with Fbxw11 and Necrosis
 Neoplasms Antibodies  >5 publications with Fbxw11 and Neoplasms
 Inflammation Antibodies  >1 publications with Fbxw11 and Inflammation
 Nervous System Diseases Antibodies  >1 publications with Fbxw11 and Nervous System Diseases
 Carcinoma Antibodies  >1 publications with Fbxw11 and Carcinoma
 Kidney Neoplasms Antibodies  >1 publications with Fbxw11 and Kidney Neoplasms
 Adenocarcinoma Antibodies  >1 publications with Fbxw11 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >1 publications with Fbxw11 and Neoplasm Metastasis

Organs/Tissues associated with Fbxw11 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >2 publications with Fbxw11 and Heart
 Lung Antibodies  >2 publications with Fbxw11 and Lung
 Liver Antibodies  >1 publications with Fbxw11 and Liver
 Intestine Antibodies  >1 publications with Fbxw11 and Intestine
 Bone Antibodies  >1 publications with Fbxw11 and Bone
 Kidney Antibodies  >1 publications with Fbxw11 and Kidney
 Brain Antibodies  >1 publications with Fbxw11 and Brain
 Embryonic Tissue Antibodies  >1 publications with Fbxw11 and Embryonic Tissue
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