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Selenide, Water Dikinase 2 (SEPHS2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1390597

This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. This protein… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Selenide, water dikinase 2 (SEPHS2), Recombinant Protein
Full Product Name
Recombinant Human Selenide, water dikinase 2 (SEPHS2)
Product Gene Name
SEPHS2 recombinant protein
Product Synonym Gene Name
SEPHS2
Sequence
AEASATGACG EAMAAAEGSS GPAGLTLGRS FSNYRPFEPQ ALGLSPSWRL TGFSGMKGSG CKVPQEALLK LLAGLTRPDV RPPLGRGLVG GQEEASQEAG LPAGAGPSPT FPALGIGMDS CVIPLRHGGL SLVQTTDFFY PLVEDPYMMG RIACANVLSD LYAMGITECD NMLMLLSVSQ SMSEEEREKV TPLMVKGFRD AAEEGGTAVT GGQTVVNPWI IIGGVATVVC QPNEFIMPDS AVVGDVLVLT KPLGTQVAVN AHQWLDNPER WNKVKMVVSR EEVELAYQEA MFNMATLNRT AAGLMHTFNA HAATDITGFG ILGHSQNLAK QQRNEVSFVI HNLPIIAKMA AVSKASGRFG LLQGTSAETS GGLLICLPRE QAARFCSEIK SSKYGEGHQA WIVGIVEKGN RTARIIDKPR VIEVLPRGAT AAVLAPDSSN ASSEPSS [There is a selenocyst eine (U) in the original sequence (Q99611). The 'U' has already been replaced with serine (S) in the sequence prior to protein manufactur e. Reason: U is generally used as a stop codon in prokaryoti c cells].
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
47,305 Da
Sequence Positions
2-448aa(U60S); Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
606218
3D Structure
ModBase 3D Structure for Q99611
Species
Human
Sequence Note
The sequence corresponds to Uniprot Q99611, expression region 2-448aa (U60S)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Sequence Information of SEPHS2 recombinant protein

There is a selenocysteine (U) in the original sequence (Q99611), red arrow and yellow highlight. The 'U' at position 60 was replaced with serine (S) in the sequence prior to protein manufacture.
Human SEPHS2 Recombinant Protein – Cat# MBS1390597

Other Notes

Small volumes of SEPHS2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEPHS2 purchase

MBS1390597 is a recombinant protein targeting SEPHS2. Also known as Recombinant Human Selenide, water dikinase 2 (SEPHS2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SEPHS2. It may not necessarily be applicable to this product.

NCBI GI #
15011844
NCBI GeneID
22928
NCBI Accession #
NP_036380.2
UniProt Primary Accession #
Q99611
UniProt Secondary Accession #
Q9BUQ2
UniProt Related Accession #
Q99611
GenBank Nucleotide #
NM_012248.3
NCBI Official Full Name
selenide, water dikinase 2
NCBI Official Synonym Full Names
selenophosphate synthetase 2
NCBI Official Symbol
SEPHS2
NCBI Official Synonym Symbols
SPS2
UniProt Protein Name
Selenide, water dikinase 2
UniProt Synonym Protein Names
Selenium donor protein 2; Selenophosphate synthase 2
UniProt Gene Name
SEPHS2
UniProt Synonym Gene Names
SPS2
NCBI Protein Information
selenide, water dikinase 2

NCBI Summary for SEPHS2

This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017]
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UniProt Comments for SEPHS2

Synthesizes selenophosphate from selenide and ATP.

Research Articles on SEPHS2

1. Data confirm interactions among components of the early steps of the selenocysteine biosynthesis pathway (SEPSECS, SECP43, SEPHS1, and SEPHS2); SECP43, which interacts with SEPSECS and SEPHS1, is a globular protein that forms oligomers in vivo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SEPHS2 recombinant protein

 Reference Product  PubMed Publications
 TXNRD1 recombinant protein  >2 publications with SEPHS2 and TXNRD1

Pathways associated with SEPHS2 recombinant protein

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Selenocompound Metabolism Pathway antibodies  Selenocompound Metabolism Pathway Diagram
 Selenocompound Metabolism Pathway antibodies  Selenocompound Metabolism Pathway Diagram

Diseases associated with SEPHS2 recombinant protein

 Disease Name  Pubmed Publications
 Death Antibodies  >1 publications with SEPHS2 and Death
 Inflammation Antibodies  >1 publications with SEPHS2 and Inflammation

Organs/Tissues associated with SEPHS2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with SEPHS2 and Liver
 Blood Antibodies  >2 publications with SEPHS2 and Blood
 Thyroid Antibodies  >1 publications with SEPHS2 and Thyroid
 Muscle Antibodies  >1 publications with SEPHS2 and Muscle
 Heart Antibodies  >1 publications with SEPHS2 and Heart
 Testis Antibodies  >1 publications with SEPHS2 and Testis
 Lung Antibodies  >1 publications with SEPHS2 and Lung
 Intestine Antibodies  >1 publications with SEPHS2 and Intestine
 Kidney Antibodies  >1 publications with SEPHS2 and Kidney
 Pituitary Gland Antibodies  >1 publications with SEPHS2 and Pituitary Gland
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