• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Serine/Threonine-Protein Kinase Nek8 (NEK8) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1390705

This gene encodes a member of the serinethreionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene… More details

$1540 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Serine/threonine-protein kinase Nek8 (Nek8), Recombinant Protein
Full Product Name
Recombinant Mouse Serine/threonine-protein kinase Nek8 (Nek8)
Product Gene Name
Nek8 recombinant protein
Product Synonym Gene Name
Nek8
Sequence
MEKYERIRVV GRGAFGIVHL CLRKADQKLV ILKQIPVEQM TKEERQAAQN ECQVLKLLNH PNVIEYYENF LEDKALMIAM EYAPGGTLAE FIQKRCNSLL EEETILHFFV QILLALHHVH THLILHRDLK TQNILLDKHR MVVKIGDFGI SKILSSKSKA YTVVGTPCYI SPELCEGKPY NQKSDIWALG CVLYELASLK RAFEAANLPA LVLKIMSGTF APISDRYSPE LRQLVLSLLS LEPAQRPPLS HIMAQPLCIR ALLNIHTDVG SVRMRRAEKS LTPGPPIASG STGSRATSAR CRGVPRGPVR PAIPPPLSSV YAWGGGLSSP LRLPMLNTEV VQVAAGRTQK AGVTRSGRLI LWEAPPLGAG GGTLLPGAVE LPQPQFVSRF LEGQSGVTIK HVACGDLFTA CLTDRGIIMT FGSGSNGCLG HGNLTDISQP TIVEALLGYE MVQVACGASH VLALSTDGEL FAWGRGDGGR LGLGTRESHN CPQQVPVAPG QEAQRVVCGI DSSMILTSPG RVLACGSNRF NKLGLDHLSL DEEPVPYQQV EEALSFTPLG SAPLDQEPLL CVDLGTAHSA AITASGDCYT FGSNQHGQLG TSSRRVSRAP CRVQGLEGIK MVMVACGDAF TVAVGAEGEV YSWGKGTRGR LGRRDEDAGL PRPVQLDETH PYMVTSVSCC HGNTLLAVRS VTDEPVPP
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
75,265 Da
Sequence Positions
1-698, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q91ZR4
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Nek8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nek8 purchase

MBS1390705 is a recombinant protein targeting Nek8. Also known as Recombinant Mouse Serine/threonine-protein kinase Nek8 (Nek8). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Nek8. It may not necessarily be applicable to this product.

NCBI GI #
19263332
NCBI GeneID
140859
NCBI Accession #
NP_543125.1
UniProt Primary Accession #
Q91ZR4
UniProt Secondary Accession #
Q3U498; Q9D685
UniProt Related Accession #
Q91ZR4
GenBank Nucleotide #
NM_080849.3
NCBI Official Full Name
serine/threonine-protein kinase Nek8
NCBI Official Synonym Full Names
NIMA (never in mitosis gene a)-related expressed kinase 8
NCBI Official Symbol
Nek8
NCBI Official Synonym Symbols
jck; b2b1449Clo; 4632401F23Rik
UniProt Protein Name
Serine/threonine-protein kinase Nek8
UniProt Synonym Protein Names
Never in mitosis A-related kinase 8; NimA-related protein kinase 8
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
Nek8
UniProt Synonym Gene Names
Jck; NimA-related protein kinase 8
NCBI Protein Information
serine/threonine-protein kinase Nek8

NCBI Summary for Nek8

This gene encodes a NIMA-related kinase. Members of this serine/threonine protein kinase family are structurally-related to NIMA (never in mitosis, gene A) which controls mitotic signaling in Aspergillus nidulans. [provided by RefSeq, Jul 2008]

UniProt Comments for Nek8

Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.

Research Articles on Nek8

1. We constructed sub-congenic lines to more specifically localize the modifier and have determined it resides in a 3.2 Mb interval containing 28 genes. These include Invs and Anks6, which are both excellent candidates for the modifier as mutations in these genes result in PKD and both genes are known to genetically and physically interact with Nek8.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Nek8 recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >12 publications with Nek8 and Kidney Diseases
 Abnormalities, Drug-Induced Antibodies  >1 publications with Nek8 and Abnormalities, Drug-Induced

Organs/Tissues associated with Nek8 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >17 publications with Nek8 and Kidney
 Lung Antibodies  >1 publications with Nek8 and Lung
 Uncharacterized Tissue Antibodies  >1 publications with Nek8 and Uncharacterized Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000