Human TSLP Recombinant Protein – Cat# MBS1393144

Thymic Stromal Lymphopoietin (TSLP) Human Recombinant Protein

Name: TSLP Recombinant Protein; Thymic Stromal Lymphopoietin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1393144
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1393144

Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells. More details

$245 / 0.02 mg (Mammalian-Cell) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thymic stromal lymphopoietin (TSLP), Recombinant Protein

Full Product Name

Recombinant Human Thymic stromal lymphopoietin

Product Gene Name

TSLP recombinant protein

Product Synonym Names

Homo sapiens (Human)

Sequence

YDFTNCDFEK IKAAYLSTIS KDLITYMSGT KSTEFNNTVS CSNRPHCLTE IQSLTFNPTA GCASLAKEMF AMKTKAALAI WCPGYSETQI NATQAMKKRR KRKVTTNKCL EQVSQLQGLW RRFNRPLLKQ Q

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

18.9 kDa

Sequence Positions

29-159aa; Full Length of Mature Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

607003

3D Structure

ModBase 3D Structure for Q969D9

Species

Homo sapiens (Human)

Production Note

Special Offer: The Mammalian-Cell host-expressed protein is manufactured from a stock plasmid containing the protein gene. Mammalian-Cellhost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Mammalian-Cell host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Mammalian-Cell host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for TSLP recombinant protein

Immunology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for TSLP recombinant protein

"Human thymic stromal lymphopoietin preferentially stimulates myeloid cells." Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M.-R., Travis M., Zurawski S.M., Johnston J., Liu Y.-J., Spits H., de Waal Malefyt R., Kastelein R.A., Bazan J.F. J. Immunol. 167:336-343(2001)

Other Notes

Small volumes of TSLP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TSLP purchase

MBS1393144 is a recombinant protein targeting TSLP. Also known as Recombinant Human Thymic stromal lymphopoietin. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TSLP. It may not necessarily be applicable to this product.

NCBI GI #

14719428

NCBI GeneID

85480

NCBI Accession #

NP_149024.1

UniProt Primary Accession #

Q969D9

UniProt Secondary Accession #

Q8IW99; Q96AU7; G3XAM8

UniProt Related Accession #

Q969D9

GenBank Nucleotide #

NM_033035.4

NCBI Official Full Name

thymic stromal lymphopoietin isoform 1

NCBI Official Synonym Full Names

thymic stromal lymphopoietin

NCBI Official Symbol

TSLP

UniProt Protein Name

Thymic stromal lymphopoietin

Protein Family

Thymic stromal lymphopoietin

UniProt Gene Name

TSLP

UniProt Entry Name

TSLP_HUMAN

NCBI Protein Information

thymic stromal lymphopoietin

NCBI Summary for TSLP

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

UniProt Comments for TSLP

TSLP: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5q22.1

Cellular Component: extracellular space

Molecular Function: cytokine activity

Research Articles on TSLP

1. This article focuses on evidence for the role of IL-25, IL-33 and TSLP in human allergic disease; although this triad of cytokines is described as epithelial derived, it is clear that their expression within lung tissue is much more widespread.[Review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TSLP recombinant protein

Reference Product	PubMed Publications
CRLF2 recombinant protein	>75 publications with TSLP and CRLF2
IL13 recombinant protein	>48 publications with TSLP and IL13
FOXP3 recombinant protein	>30 publications with TSLP and FOXP3
CCL17 recombinant protein	>29 publications with TSLP and CCL17
IL4 recombinant protein	>16 publications with TSLP and IL4
IL7R recombinant protein	>7 publications with TSLP and IL7R
TNFRSF4 recombinant protein	>3 publications with TSLP and TNFRSF4
STAT5A recombinant protein	>3 publications with TSLP and STAT5A
STAT5B recombinant protein	>1 publications with TSLP and STAT5B

Pathways associated with TSLP recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
TSLP Signaling Pathway antibodies	TSLP Signaling Pathway Diagram

Diseases associated with TSLP recombinant protein

Disease Name	Pubmed Publications
Hypersensitivity Antibodies	>347 publications with TSLP and Hypersensitivity
Asthma Antibodies	>260 publications with TSLP and Asthma
Dermatitis, Atopic Antibodies	>206 publications with TSLP and Dermatitis, Atopic
Lung Diseases Antibodies	>172 publications with TSLP and Lung Diseases
Disease Models, Animal Antibodies	>94 publications with TSLP and Disease Models, Animal
Necrosis Antibodies	>90 publications with TSLP and Necrosis
Eosinophilic Esophagitis Antibodies	>27 publications with TSLP and Eosinophilic Esophagitis
Drug Hypersensitivity Antibodies	>26 publications with TSLP and Drug Hypersensitivity
Fibrosis Antibodies	>24 publications with TSLP and Fibrosis
Hyperplasia Antibodies	>23 publications with TSLP and Hyperplasia

Organs/Tissues associated with TSLP recombinant protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>208 publications with TSLP and Skin
Lung Antibodies	>168 publications with TSLP and Lung
Bone Marrow Antibodies	>45 publications with TSLP and Bone Marrow
Eye Antibodies	>14 publications with TSLP and Eye
Brain Antibodies	>10 publications with TSLP and Brain
Connective Tissue Antibodies	>3 publications with TSLP and Connective Tissue
Salivary Gland Antibodies	>3 publications with TSLP and Salivary Gland
Thyroid Antibodies	>1 publications with TSLP and Thyroid