Fibrinogen Gamma Chain (FGG) Mouse Recombinant Protein

This gene encodes the gamma subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Mice lacking the encoded protein did not possess detectable amounts of plasma fibrinogen. Pregnant mice lacking the encoded protein die due to heavy bleeding during delivery. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (). Fibrin has a major function in hemostasis as one of the primary components of blood clots (). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (). May also facilitate the immune response via both innate and T-cell mediated pathways ().