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CUGBP Elav-Like Family Member 4 (CELF4) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1396296

Members of the CELFBRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA… More details

$1265 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CUGBP Elav-like family member 4 (CELF4), Recombinant Protein
Full Product Name
Recombinant Human CUGBP Elav-like family member 4 (CELF4)
Product Gene Name
CELF4 recombinant protein
Product Synonym Gene Name
CELF4
Sequence
MYIKMATLAN GQADNASLST NGLGSSPGSA GHMNGLSHSP GNPSTIPMKD HDAIKLFIGQ IPRNLDEKDL KPLFEEFGKI YELTVLKDRF TGMHKGCAFL TYCERESALK AQSALHEQKT LPGMNRPIQV KPADSESRGG SSCLRQPPSQ DRKLFVGMLN KQQSEDDVRR LFEAFGNIEE CTILRGPDGN SKGCAFVKYS SHAEAQAAIN ALHGSQTMPG ASSSLVVKFA DTDKERTMRR MQQMAGQMGM FNPMAIPFGA YGAYAQALMQ QQAALMASVA QGGYLNPMAA FAAAQMQQMA ALNMNGLAAA PMTPTSGGST PPGITAPAVP SIPSPIGVNG FTGLPPQANG QPAAEAVFAN GIHPYPAQSP TAADPLQQAY AGVQQYAGPA AYPAAYGQIS QAFPQPPPMI PQQQREGPEG CNLFIYHLPQ EFGDAELMQM FLPFGFVSFD NPASAQTAIQ AMNGFQIGMK RLKVQLKRPK DANRPY
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
47,727 Da
Sequence Positions
1-486, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
612679
3D Structure
ModBase 3D Structure for Q9BZC1
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CELF4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CELF4 purchase

MBS1396296 is a recombinant protein targeting CELF4. Also known as Recombinant Human CUGBP Elav-like family member 4 (CELF4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CELF4. It may not necessarily be applicable to this product.

NCBI GI #
187761299
NCBI GeneID
56853
NCBI Accession #
NP_001020258.1
UniProt Primary Accession #
Q9BZC1
UniProt Secondary Accession #
Q59EN7; Q86XB9; Q8N2M6; Q9BQ96; Q9NR84; Q9NR85
UniProt Related Accession #
Q9BZC1
GenBank Nucleotide #
NM_001025087.1
NCBI Official Full Name
CUGBP Elav-like family member 4 isoform 2
NCBI Official Synonym Full Names
CUGBP Elav-like family member 4
NCBI Official Symbol
CELF4
NCBI Official Synonym Symbols
CELF-4; BRUNOL4
UniProt Protein Name
CUGBP Elav-like family member 4
UniProt Synonym Protein Names
Bruno-like protein 4; CUG-BP- and ETR-3-like factor 4; RNA-binding protein BRUNOL-4
Protein Family
CUGBP Elav-like family
UniProt Gene Name
CELF4
UniProt Synonym Gene Names
BRUNOL4; CELF-4
NCBI Protein Information
CUGBP Elav-like family member 4

NCBI Summary for CELF4

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CELF4

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
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Research Articles on CELF4

1. The present study refines the molecular and neuropsychiatric phenotype associated with 18q12.2 deletion leading to CELF4 haploinsufficiency and provides evidence for a role for CELF4 in brain development and autism spectrum disorders.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CELF4 recombinant protein

 Products by Pathway  Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with CELF4 recombinant protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >2 publications with CELF4 and Fibrosis
 Congenital Abnormalities Antibodies  >1 publications with CELF4 and Congenital Abnormalities
 Neoplasms Antibodies  >1 publications with CELF4 and Neoplasms
 Heart Defects, Congenital Antibodies  >1 publications with CELF4 and Heart Defects, Congenital

Organs/Tissues associated with CELF4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with CELF4 and Brain
 Nerve Antibodies  >8 publications with CELF4 and Nerve
 Muscle Antibodies  >6 publications with CELF4 and Muscle
 Embryonic Tissue Antibodies  >4 publications with CELF4 and Embryonic Tissue
 Eye Antibodies  >3 publications with CELF4 and Eye
 Ovary Antibodies  >1 publications with CELF4 and Ovary
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