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NCK-Interacting Protein with SH3 Domain (NCKIPSD) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1396596

This protein is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation.… More details

$1580 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NCK-interacting protein with SH3 domain (NCKIPSD), Recombinant Protein
Full Product Name
Recombinant Human NCK-interacting protein with SH3 domain (NCKIPSD)
Product Gene Name
NCKIPSD recombinant protein
Product Synonym Gene Name
NCKIPSD
Sequence
MYRALYAFRS AEPNALAFAA GETFLVLERS SAHWWLAARA RSGETGYVPP AYLRRLQGLE QDVLQAIDRA IEAVHNTAMR DGGKYSLEQR GVLQKLIHHR KETLSRRGPS ASSVAVMTSS TSDHHLDAAA ARQPNGVCRA GFERQHSLPS SEHLGADGGL YQIPLPSSQI PPQPRRAAPT TPPPPVKRRD REALMASGSG GHNTMPSGGN SVSSGSSVSS TSLDTLYTSS SPSEPGSSCS PTPPPVPRRG THTTVSQVQP PPSKASAPEP PAEEEVATGT TSASDDLEAL GTLSLGTTEE KAAAEAAVPR TIGAELMELV RRNTGLSHEL CRVAIGIIVG HIQASVPASS PVMEQVLLSL VEGKDLSMAL PSGQVCHDQQ RLEVIFADLA RRKDDAQQRS WALYEDEGVI RCYLEELLHI LTDADPEVCK KMCKRNEFES VLALVAYYQM EHRASLRLLL LKCFGAMCSL DAAIISTLVS SVLPVELARD MQTDTQDHQK LCYSALILAM VFSMGEAVPY AHYEHLGTPF AQFLLNIVED GLPLDTTEQL PDLCVNLLLA LNLHLPAADQ NVIMAALSKH ANVKIFSEKL LLLLNRGDDP VRIFKHEPQP PHSVLKFLQD VFGSPATAAI FYHTDMMALI DITVRHIADL SPGDKLRMEY LSLMHAIVRT TPYLQHRHRL PDLQAILRRI LNEEETSPQC QMDRMIVREM CKEFLVLGEA PS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
64,196 Da
Sequence Positions
1-722, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
606671
3D Structure
ModBase 3D Structure for Q9NZQ3
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NCKIPSD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCKIPSD purchase

MBS1396596 is a recombinant protein targeting NCKIPSD. Also known as Recombinant Human NCK-interacting protein with SH3 domain (NCKIPSD). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NCKIPSD. It may not necessarily be applicable to this product.

NCBI GI #
7705266
NCBI GeneID
51517
NCBI Accession #
NP_057537.1
UniProt Primary Accession #
Q9NZQ3
UniProt Secondary Accession #
Q6GU34; Q6SPF3; Q8TC10; Q9UGM8; B4DFL5
UniProt Related Accession #
Q9NZQ3
GenBank Nucleotide #
NM_016453.3
NCBI Official Full Name
NCK-interacting protein with SH3 domain isoform 1
NCBI Official Synonym Full Names
NCK interacting protein with SH3 domain
NCBI Official Symbol
NCKIPSD
NCBI Official Synonym Symbols
DIP; DIP1; ORF1; WISH; VIP54; AF3P21; SPIN90; WASLBP
UniProt Protein Name
NCK-interacting protein with SH3 domain
UniProt Synonym Protein Names
54 kDa VacA-interacting protein; 54 kDa vimentin-interacting protein; VIP54; 90 kDa SH3 protein interacting with Nck; AF3p21; Dia-interacting protein 1; DIP-1; Diaphanous protein-interacting protein; SH3 adapter protein SPIN90; WASP-interacting SH3-domain protein; WISH; Wiskott-Aldrich syndrome protein-interacting protein
Protein Family
NCK-interacting protein with SH3 domain
UniProt Gene Name
NCKIPSD
UniProt Synonym Gene Names
AF3P21; SPIN90; VIP54; DIP-1; WISH
NCBI Protein Information
NCK-interacting protein with SH3 domain

NCBI Summary for NCKIPSD

The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
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UniProt Comments for NCKIPSD

Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.
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Research Articles on NCKIPSD

1. Low SPIN90 expression is associated with Breast Cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NCKIPSD recombinant protein

 Reference Product  PubMed Publications
 WASL recombinant protein  >3 publications with NCKIPSD and WASL
 RAC1 recombinant protein  >1 publications with NCKIPSD and RAC1
 BAIAP2 recombinant protein  >1 publications with NCKIPSD and BAIAP2
 GRB2 recombinant protein  >1 publications with NCKIPSD and GRB2

Pathways associated with NCKIPSD recombinant protein

 Products by Pathway  Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway antibodies  Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway Diagram

Diseases associated with NCKIPSD recombinant protein

 Disease Name  Pubmed Publications
 Blood Coagulation Disorders Antibodies  >3 publications with NCKIPSD and Blood Coagulation Disorders
 Lung Neoplasms Antibodies  >1 publications with NCKIPSD and Lung Neoplasms
 Nervous System Diseases Antibodies  >1 publications with NCKIPSD and Nervous System Diseases
 Disease Models, Animal Antibodies  >1 publications with NCKIPSD and Disease Models, Animal
 Liver Neoplasms Antibodies  >1 publications with NCKIPSD and Liver Neoplasms

Organs/Tissues associated with NCKIPSD recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >26 publications with NCKIPSD and Muscle
 Brain Antibodies  >8 publications with NCKIPSD and Brain
 Nerve Antibodies  >4 publications with NCKIPSD and Nerve
 Kidney Antibodies  >3 publications with NCKIPSD and Kidney
 Blood Antibodies  >3 publications with NCKIPSD and Blood
 Heart Antibodies  >2 publications with NCKIPSD and Heart
 Embryonic Tissue Antibodies  >1 publications with NCKIPSD and Embryonic Tissue
 Lung Antibodies  >1 publications with NCKIPSD and Lung
 Liver Antibodies  >1 publications with NCKIPSD and Liver
 Vascular Antibodies  >1 publications with NCKIPSD and Vascular
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