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C-Type Lectin Domain Family 7 Member A (CLEC7A) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1397147

This gene encodes a member of the C-type lectinC-type lectin-like domain (CTLCTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor… More details

$1305 / 0.5 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
C-type lectin domain family 7 member A (CLEC7A), Recombinant Protein
Full Product Name
Recombinant Human C-type lectin domain family 7 member A (CLEC7A), partial
Product Gene Name
CLEC7A recombinant protein
Product Synonym Gene Name
CLEC7A
Sequence
TMAIW RSNSGSNTLE NGYFLSRNKE NHSQPTQSSL EDSVTPTKAV KTTGVLSSPC PPNWIIYEKS CYLFSMSLNS WDGSKRQCWQ LGSNLLKIDS SNELGFIVKQ VSSQPDNSFW IGLSRPQTEV PWLWEDGSTF SSNLFQIRTT ATQENPSPNC VWIHVSVIYD QLCSVPSYSI CEKKFSM
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
13,138 Da
Sequence Positions
66-247
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
606264
3D Structure
ModBase 3D Structure for Q9BXN2
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CLEC7A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLEC7A purchase

MBS1397147 is a recombinant protein targeting CLEC7A. Also known as Recombinant Human C-type lectin domain family 7 member A (CLEC7A), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CLEC7A. It may not necessarily be applicable to this product.

NCBI GI #
13384604
NCBI GeneID
64581
NCBI Accession #
NP_072092.2
UniProt Primary Accession #
Q9BXN2
UniProt Secondary Accession #
Q6IPS7; Q96D32; Q96DR9; Q96LD3; Q96PA4; Q96PA5; Q96PA6; B2R861; B7Z494; B7Z5A9; B7Z5B9
UniProt Related Accession #
Q9BXN2
GenBank Nucleotide #
NM_022570.4
NCBI Official Full Name
C-type lectin domain family 7 member A isoform b
NCBI Official Synonym Full Names
C-type lectin domain containing 7A
NCBI Official Symbol
CLEC7A
NCBI Official Synonym Symbols
BGR; CD369; CANDF4; SCARE2; DECTIN1; CLECSF12
UniProt Protein Name
C-type lectin domain family 7 member A
UniProt Synonym Protein Names
Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1
Protein Family
C-type lectin domain family
UniProt Gene Name
CLEC7A
UniProt Synonym Gene Names
BGR; CLECSF12; DECTIN1; DC-associated C-type lectin 1; Dectin-1
NCBI Protein Information
C-type lectin domain family 7 member A

NCBI Summary for CLEC7A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
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UniProt Comments for CLEC7A

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation ().
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Research Articles on CLEC7A

1. These results suggest that the intracellular domain, not ligand-binding domain, of Dectin-1 determines the species-specific ligand profile.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CLEC7A recombinant protein

 Products by Pathway  Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with CLEC7A recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with CLEC7A and Inflammation
 Necrosis Antibodies  >5 publications with CLEC7A and Necrosis
 Lung Diseases Antibodies  >2 publications with CLEC7A and Lung Diseases
 Colitis Antibodies  >2 publications with CLEC7A and Colitis
 Atherosclerosis Antibodies  >1 publications with CLEC7A and Atherosclerosis
 Liver Cirrhosis Antibodies  >1 publications with CLEC7A and Liver Cirrhosis
 Non-alcoholic Fatty Liver Disease Antibodies  >1 publications with CLEC7A and Non-alcoholic Fatty Liver Disease
 Fatty Liver Antibodies  >1 publications with CLEC7A and Fatty Liver
 Neoplasms Antibodies  >1 publications with CLEC7A and Neoplasms
 Liver Diseases Antibodies  >1 publications with CLEC7A and Liver Diseases

Organs/Tissues associated with CLEC7A recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >20 publications with CLEC7A and Blood
 Lung Antibodies  >6 publications with CLEC7A and Lung
 Bone Marrow Antibodies  >3 publications with CLEC7A and Bone Marrow
 Intestine Antibodies  >2 publications with CLEC7A and Intestine
 Vascular Antibodies  >1 publications with CLEC7A and Vascular
 Spleen Antibodies  >1 publications with CLEC7A and Spleen
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