Human SNX1 Recombinant Protein – Cat# MBS1398606

Sorting Nexin-1 (SNX1) Human Recombinant Protein

Name: SNX1 Recombinant Protein; Sorting Nexin-1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1398606
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1398606

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming… More details

$335 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sorting nexin-1 (SNX1), Recombinant Protein

Full Product Name

Recombinant Human Sorting nexin-1

Product Gene Name

SNX1 recombinant protein

Sequence

MASGGGGCSA SERLPPPFPG LEPESEGAAG GSEPEAGDSD TEGEDIFTGA AVVSKHQSPK ITTSLLPINN GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKKVLA KTLISLPPQE ATNSSKPQPT YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPLFRSKQ FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQTLS GAGLLKMFNK ATDAVSKMTI KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTAQFAKS LAMLGSSEDN TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI RLLAIVRAAF DQRMKTWQRW QDAQATLQKK REAEARLLWA NKPDKLQQAK DEILEWESRV TQYERDFERI STVVRKEVIR FEKEKSKDFK NHVIKYLETL LYSQQQLAKY WEAFLPEAKA IS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

75.1 kDa

Sequence Positions

1-522aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

601272

3D Structure

ModBase 3D Structure for Q13596

Product Categories/Family for SNX1 recombinant protein

Signal Transduction

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for SNX1 recombinant protein

Enhanced degradation of EGF receptors by a sorting nexin, SNX1.Kurten R.C., Cadena D.L., Gill G.N.Science 272:1008-1010(1996)

Other Notes

Small volumes of SNX1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNX1 purchase

MBS1398606 is a recombinant protein targeting SNX1. Also known as Recombinant Human Sorting nexin-1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for SNX1. It may not necessarily be applicable to this product.

NCBI GI #

339409190

NCBI GeneID

6642

NCBI Accession #

NP_001229862.1

UniProt Primary Accession #

Q13596

UniProt Secondary Accession #

O60750; O60751; Q6ZRJ8; A6NM19; A8K6T7; H0Y2M5

UniProt Related Accession #

Q13596

GenBank Nucleotide #

NM_001242933.1

NCBI Official Full Name

sorting nexin-1 isoform d

NCBI Official Synonym Full Names

sorting nexin 1

NCBI Official Symbol

SNX1

NCBI Official Synonym Symbols

VPS5; HsT17379

UniProt Protein Name

Sorting nexin-1

Protein Family

Sorting nexin

UniProt Gene Name

SNX1

UniProt Entry Name

SNX1_HUMAN

NCBI Protein Information

sorting nexin-1

NCBI Summary for SNX1

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for SNX1

SNX1: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: cytoplasm; cytosol; early endosome membrane; endosome membrane; extrinsic to membrane; Golgi apparatus; intracellular membrane-bound organelle; lamellipodium; membrane; protein complex; retromer complex

Molecular Function: epidermal growth factor receptor binding; identical protein binding; insulin receptor binding; phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: intracellular protein transport; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of protein catabolic process; receptor internalization; retrograde transport, endosome to Golgi; vesicle organization and biogenesis

Research Articles on SNX1

1. we suggest that SNX1 is involved in the negative regulation of ligand-induced EGFR phosphorylation and mediates EGFR/pEGFR trafficking out of early endosomes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SNX1 recombinant protein

Reference Product	PubMed Publications
SNX2 recombinant protein	>26 publications with SNX1 and SNX2
VPS35 recombinant protein	>22 publications with SNX1 and VPS35
VPS29 recombinant protein	>17 publications with SNX1 and VPS29
EGFR recombinant protein	>11 publications with SNX1 and EGFR
SNX6 recombinant protein	>11 publications with SNX1 and SNX6
VPS26A recombinant protein	>9 publications with SNX1 and VPS26A
VPS26B recombinant protein	>1 publications with SNX1 and VPS26B

Pathways associated with SNX1 recombinant protein

Products by Pathway	Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
TGF-beta Receptor Signaling Pathway antibodies	TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with SNX1 recombinant protein

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>5 publications with SNX1 and Kidney Diseases
Cardiovascular Diseases Antibodies	>3 publications with SNX1 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>1 publications with SNX1 and Disease Models, Animal
Liver Diseases Antibodies	>1 publications with SNX1 and Liver Diseases
Nervous System Malformations Antibodies	>1 publications with SNX1 and Nervous System Malformations
Hypertension Antibodies	>1 publications with SNX1 and Hypertension
Neurobehavioral Manifestations Antibodies	>1 publications with SNX1 and Neurobehavioral Manifestations
Adenocarcinoma Antibodies	>1 publications with SNX1 and Adenocarcinoma
Liver Neoplasms Antibodies	>1 publications with SNX1 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>1 publications with SNX1 and Carcinoma, Hepatocellular

Organs/Tissues associated with SNX1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>9 publications with SNX1 and Kidney
Lung Antibodies	>7 publications with SNX1 and Lung
Nerve Antibodies	>4 publications with SNX1 and Nerve
Liver Antibodies	>3 publications with SNX1 and Liver
Embryonic Tissue Antibodies	>3 publications with SNX1 and Embryonic Tissue
Brain Antibodies	>3 publications with SNX1 and Brain
Blood Antibodies	>2 publications with SNX1 and Blood
Heart Antibodies	>1 publications with SNX1 and Heart
Bone Marrow Antibodies	>1 publications with SNX1 and Bone Marrow
Intestine Antibodies	>1 publications with SNX1 and Intestine