Human APOBEC3C Recombinant Protein – Cat# MBS1400886

Probable DNA Dc->Du-Editing Enzyme APOBEC-3c (APOBEC3C) Human Recombinant Protein

Name: APOBEC3C Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1400886
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1400886

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Probable DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C), Recombinant Protein

Full Product Name

Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)

Product Gene Name

APOBEC3C recombinant protein

Product Synonym Gene Name

APOBEC3C; APOBEC1L; PBI

Product Synonym Names

Probable DNA dC->dU-editing enzyme APOBEC-3C; EC=3.5.4.-; APOBEC1-like; Phorbolin I

Sequence

MNPQIRNPMK AMYPGTFYFQ FKNLWEANDR DETWLCFTVE GIKRRSVVSW KTGVFRNQVD SETHCHAERC FLSWFCDDIL SPNTKYQVTW YTSWSPCPDC AGEVAEFLAR HSNVNLTIFT ARLYYFQYPC YQEGLRSLSQ EGVAVEIMDY EDFKYCWENF VYNDNEPFKP WKGLKTNFRL LKRRLRESLQ

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

49.8 kDa

Sequence Positions

1-190aa; Full Length of BC011739

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

607750

3D Structure

ModBase 3D Structure for Q9NRW3

Species

Homo sapiens (Human)

Product Categories/Family for APOBEC3C recombinant protein

Epigenetics and Nuclear Signaling

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of APOBEC3C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APOBEC3C purchase

MBS1400886 is a recombinant protein targeting APOBEC3C. Also known as Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for APOBEC3C. It may not necessarily be applicable to this product.

NCBI GI #

22907039

NCBI GeneID

27350

NCBI Accession #

NP_055323.2

UniProt Primary Accession #

Q9NRW3

UniProt Secondary Accession #

Q5JZ92; Q7Z2N7; Q96F12; B2R884

UniProt Related Accession #

Q9NRW3

GenBank Nucleotide #

NM_014508.2

NCBI Official Full Name

DNA dC->dU-editing enzyme APOBEC-3C

NCBI Official Synonym Full Names

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C

NCBI Official Symbol

APOBEC3C

NCBI Official Synonym Symbols

A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3

UniProt Protein Name

DNA dC->dU-editing enzyme APOBEC-3C

UniProt Synonym Protein Names

APOBEC1-like; Phorbolin I

Protein Family

DNA dC->dU-editing enzyme

UniProt Gene Name

APOBEC3C

UniProt Synonym Gene Names

APOBEC1L; PBI; A3C

UniProt Entry Name

ABC3C_HUMAN

NCBI Protein Information

DNA dC->dU-editing enzyme APOBEC-3C; phorbolin I; probable DNA dC->dU-editing enzyme APOBEC-3C; apolipoprotein B editing enzyme catalytic polypeptide-like 3C

NCBI Summary for APOBEC3C

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]

UniProt Comments for APOBEC3C

APOBEC3C: Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: RNA-binding; EC 3.5.4.-; Hydrolase

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; zinc ion binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Biological Process: viral reproduction; negative regulation of viral genome replication; innate immune response; cytidine deamination; defense response to virus

Research Articles on APOBEC3C

1. APOBEC3 deaminases upregulated by IFN-beta induce E2 hypermutation of HPV16 in cervical keratinocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with APOBEC3C recombinant protein

Reference Product	PubMed Publications
APOBEC3F recombinant protein	>24 publications with APOBEC3C and APOBEC3F
CUL5 recombinant protein	>2 publications with APOBEC3C and CUL5
APOB recombinant protein	>1 publications with APOBEC3C and APOB

Diseases associated with APOBEC3C recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>2 publications with APOBEC3C and Liver Diseases
Liver Neoplasms Antibodies	>2 publications with APOBEC3C and Liver Neoplasms
Sarcoma Antibodies	>1 publications with APOBEC3C and Sarcoma
Carcinoma Antibodies	>1 publications with APOBEC3C and Carcinoma
Carcinoma, Hepatocellular Antibodies	>1 publications with APOBEC3C and Carcinoma, Hepatocellular
Adenocarcinoma Antibodies	>1 publications with APOBEC3C and Adenocarcinoma

Organs/Tissues associated with APOBEC3C recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>7 publications with APOBEC3C and Blood
Liver Antibodies	>3 publications with APOBEC3C and Liver
Kidney Antibodies	>2 publications with APOBEC3C and Kidney
Brain Antibodies	>1 publications with APOBEC3C and Brain
Prostate Antibodies	>1 publications with APOBEC3C and Prostate