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FAS Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140095

Introduction: The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that… More details

$455 / 0.5 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
FAS, Monoclonal Antibody
Full Product Name
Mouse Anti Human FAS (CD95) Blocking
Product Gene Name
anti-FAS antibody
Product Synonym Names
FAS Antibody; FAS Blocking Antibody (CD95), Mouse anti Human; FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; CD95; Tumor necrosis factor receptor superfamily member 6 TNR6; APT1; FAS1; TNFRSF6
Clonality
Monoclonal
Isotype
IgG1
Clone Number
NYRhFAS
Host
Mouse
Purity/Purification
Ion exchange column Protein concentration1 mg/ml in PBS (after reconstitution).
Preparation and Storage
In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
Antibody is shipped lyophilized at ambient temperature.
Molecular Weight
273,427 Da
OMIM
600212
Additional Information
This is a BLOCKING antibody and will block FAS-mediated apoptosis.
Reconstitution
Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Immunogen
Recombinant Human FAS.

Product Categories/Family for anti-FAS antibody

Anti-Human CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine
Applications Tested/Suitable for anti-FAS antibody
ELISA (EIA)
Application Notes for anti-FAS antibody
By direct ELISA, 1:10,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig.

Other Notes

Small volumes of anti-FAS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FAS purchase

MBS140095 is an antibody targeting FAS. Also known as Mouse Anti Human FAS (CD95) Blocking. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for FAS. It may not necessarily be applicable to this product.

NCBI GI #
41872631
NCBI GeneID
2194
NCBI Accession #
NP_004095.4
UniProt Secondary Accession #
Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0
UniProt Related Accession #
P49327
GenBank Nucleotide #
NM_004104.4
NCBI Official Full Name
fatty acid synthase
NCBI Official Synonym Full Names
fatty acid synthase
NCBI Official Symbol
FASN
NCBI Official Synonym Symbols
FAS; OA-519; SDR27X1
UniProt Protein Name
Fatty acid synthase
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
FASN
UniProt Synonym Gene Names
FAS
UniProt Entry Name
FAS_HUMAN
NCBI Protein Information
fatty acid synthase; short chain dehydrogenase/reductase family 27X, member 1

NCBI Summary for FAS

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
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UniProt Comments for FAS

FASN: a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Protein type: EC 2.3.1.85; EC 4.2.1.59; Acetyltransferase; EC 1.1.1.100; EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 3.1.2.14; Lyase; EC 1.3.1.39; Oxidoreductase; Hydrolase; Lipid Metabolism - fatty acid biosynthesis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: Golgi apparatus; glycogen granule; membrane; mitochondrion; cytoplasm; plasma membrane; melanosome; cytosol

Molecular Function: protein homodimerization activity; fatty-acid synthase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; zinc ion binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; drug binding; [acyl-carrier-protein] S-acetyltransferase activity; 3-oxoacyl-[acyl-carrier-protein] reductase activity; protein binding; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; [acyl-carrier-protein] S-malonyltransferase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity

Biological Process: osteoblast differentiation; vitamin metabolic process; acetyl-CoA metabolic process; pantothenate metabolic process; positive regulation of cellular metabolic process; energy reserve metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid metabolic process; fatty acid biosynthetic process; water-soluble vitamin metabolic process
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Research Articles on FAS

1. Crystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FAS antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 ChREBP Activates Metabolic Gene Expression Pathway antibodies  ChREBP Activates Metabolic Gene Expression Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram

Diseases associated with anti-FAS antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >145 publications with FAS and Fatty Liver
 Obesity Antibodies  >108 publications with FAS and Obesity
 Liver Diseases Antibodies  >66 publications with FAS and Liver Diseases
 Breast Neoplasms Antibodies  >52 publications with FAS and Breast Neoplasms
 Insulin Resistance Antibodies  >49 publications with FAS and Insulin Resistance
 Inflammation Antibodies  >40 publications with FAS and Inflammation
 Disease Models, Animal Antibodies  >26 publications with FAS and Disease Models, Animal
 Weight Loss Antibodies  >22 publications with FAS and Weight Loss
 Necrosis Antibodies  >19 publications with FAS and Necrosis
 Weight Gain Antibodies  >19 publications with FAS and Weight Gain

Organs/Tissues associated with anti-FAS antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >169 publications with FAS and Liver
 Adipose Tissue Antibodies  >120 publications with FAS and Adipose Tissue
 Blood Antibodies  >105 publications with FAS and Blood
 Connective Tissue Antibodies  >74 publications with FAS and Connective Tissue
 Muscle Antibodies  >54 publications with FAS and Muscle
 Prostate Antibodies  >49 publications with FAS and Prostate
 Mammary Gland Antibodies  >35 publications with FAS and Mammary Gland
 Lung Antibodies  >23 publications with FAS and Lung
 Brain Antibodies  >18 publications with FAS and Brain
 Kidney Antibodies  >18 publications with FAS and Kidney
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