Mouse Anti-AICDA Monoclonal Antibody – Cat# MBS140210

Activation-Induced Cytidine Deaminase (AICDA) Antibody – Mouse Monoclonal

Name: AICDA Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS140210
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140210

Introduction: AICDA is an RNA-editing deaminase which belongs to the cytidine deaminase family. AICDA is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in the AICDA gene are the cause of… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Activation-induced cytidine deaminase (AICDA), Monoclonal Antibody

Full Product Name

Mouse Anti Human Activation-induced cytidine deaminase

Product Gene Name

anti-AICDA antibody

Product Synonym Names

AICDA Antibody; Activation-induced cytidine deaminase, Mouse Anti Human; Activation-induced cytidine deaminase; Cytidine aminohydrolase; AICDA; AID; ARP2; CDA2; HIGM2

Clonality

Monoclonal

Isotype

IgG1 heavy chain and kappa light chain

Clone Number

P2D3AT

Host

Mouse

Form/Format

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

Purity/Purification

AICDA antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

Preparation and Storage

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.

Molecular Weight

22,614 Da

OMIM

605257

Immunogen

Anti-human AICDA mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human AICDA amino acids 1-54 purified from E Coli.

Product Categories/Family for anti-AICDA antibody

Monoclonal Antibodies; Anti-Human Enzymes; Monoclonal Antibodies; Anti Human Enzyme

Applications Tested/Suitable for anti-AICDA antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-AICDA antibody

AICDA antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.

Other Notes

Small volumes of anti-AICDA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AICDA purchase

MBS140210 is an antibody targeting AICDA. Also known as Mouse Anti Human Activation-induced cytidine deaminase. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for AICDA. It may not necessarily be applicable to this product.

NCBI GI #

10190700

NCBI GeneID

57379

NCBI Accession #

NP_065712.1

UniProt Secondary Accession #

Q6QJ81; Q8NFC1

UniProt Related Accession #

Q9GZX7

GenBank Nucleotide #

NM_020661.2

NCBI Official Full Name

single-stranded DNA cytosine deaminase

NCBI Official Synonym Full Names

activation-induced cytidine deaminase

NCBI Official Symbol

AICDA

NCBI Official Synonym Symbols

AID; ARP2; CDA2; HIGM2; HEL-S-284

UniProt Protein Name

Single-stranded DNA cytosine deaminase

UniProt Synonym Protein Names

Activation-induced cytidine deaminase; Cytidine aminohydrolase

Protein Family

Single-stranded DNA cytosine deaminase

UniProt Gene Name

AICDA

UniProt Synonym Gene Names

AID

UniProt Entry Name

AICDA_HUMAN

NCBI Protein Information

single-stranded DNA cytosine deaminase; cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos

NCBI Summary for AICDA

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]

UniProt Comments for AICDA

AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: Hydrolase; EC 3.5.4.38

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; exosome (RNase complex); nucleus

Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity

Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing

Disease: Immunodeficiency With Hyper-igm, Type 2

Research Articles on AICDA

1. AID activity and its relationship to chromosome folding and the B cell regulome was studied; find that AID-mediated lesions occur predominantly within B cell super-enhancers and regulatory clusters; further show that the structural and transcriptional features of these domains help explain AID tumorigenic activity in the B cell compartment of mice and humans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AICDA antibody

Reference Product	PubMed Publications
TNFSF13B antibody	>6 publications with AICDA and TNFSF13B
STAT6 antibody	>5 publications with AICDA and STAT6
IL4 antibody	>3 publications with AICDA and IL4

Pathways associated with anti-AICDA antibody

Products by Pathway	Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Primary Immunodeficiency Pathway antibodies	Primary Immunodeficiency Pathway Diagram
Primary Immunodeficiency Pathway antibodies	Primary Immunodeficiency Pathway Diagram

Diseases associated with anti-AICDA antibody

Disease Name	Pubmed Publications
Leukemia Antibodies	>65 publications with AICDA and Leukemia
Leukemia, Lymphoid Antibodies	>46 publications with AICDA and Leukemia, Lymphoid
Inflammation Antibodies	>38 publications with AICDA and Inflammation
Autoimmune Diseases Antibodies	>38 publications with AICDA and Autoimmune Diseases
Necrosis Antibodies	>28 publications with AICDA and Necrosis
Disease Models, Animal Antibodies	>27 publications with AICDA and Disease Models, Animal
Hyper-IgM Immunodeficiency Syndrome Antibodies	>20 publications with AICDA and Hyper-IgM Immunodeficiency Syndrome
Liver Diseases Antibodies	>18 publications with AICDA and Liver Diseases
Adenocarcinoma Antibodies	>14 publications with AICDA and Adenocarcinoma
Nervous System Diseases Antibodies	>12 publications with AICDA and Nervous System Diseases

Organs/Tissues associated with anti-AICDA antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>463 publications with AICDA and Blood
Lymph Node Antibodies	>101 publications with AICDA and Lymph Node
Lymph Antibodies	>26 publications with AICDA and Lymph
Kidney Antibodies	>26 publications with AICDA and Kidney
Tonsil Antibodies	>12 publications with AICDA and Tonsil
Pharynx Antibodies	>8 publications with AICDA and Pharynx
Testis Antibodies	>2 publications with AICDA and Testis
Pancreas Antibodies	>1 publications with AICDA and Pancreas
Uncharacterized Tissue Antibodies	>1 publications with AICDA and Uncharacterized Tissue