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E3 Ubiquitin-Protein Ligase FANCL (FANCL) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1402424

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH… More details

$1105 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E3 ubiquitin-protein ligase FANCL (FANCL), Recombinant Protein
Full Product Name
Recombinant Human E3 ubiquitin-protein ligase FANCL (FANCL)
Product Gene Name
Product Synonym Gene Name
FANCL
Sequence
AVTEASLLRQ CPLLLPQNRS KTVYEGFISA QGRDFHLRIV LPEDLQLKNA RLLCSWQLRT ILSGYHRIVQ QRMQHSPDLM SFMMELKMLL EVALKNRQEL YALPPPPQFY SSLIEEIGTL GWDKLVYADT CFSTIKLKAE DASGREHLIT LKLKAKYPAE SPDYFVDFPV PFCASWTPQS SLISIYSQFL AAIESLKAFW DVMDEIDEKT WVLEPEKPPR SATARRIALG NNVSINIEVD PRHPTMLPEC FFLGADHVVK PLGIKLSRNI HLWDPENSVL QNLKDVLEID FPARAILEKS DFTMDCGICY AYQLDGTIPD QVCDNSQCGQ PFHQICLYEW LRGLLTSRQS FNIIFGECPY CSKPITLKMS GRKH
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
43,430 Da
Sequence Positions
2-375, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
608111
3D Structure
ModBase 3D Structure for Q9NW38
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FANCL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FANCL purchase

MBS1402424 is a recombinant protein targeting FANCL. Also known as Recombinant Human E3 ubiquitin-protein ligase FANCL (FANCL). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for FANCL. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
E3 ubiquitin-protein ligase FANCL isoform 1
NCBI Official Synonym Full Names
Fanconi anemia complementation group L
NCBI Official Symbol
FANCL
NCBI Official Synonym Symbols
POG; PHF9; FAAP43
UniProt Protein Name
E3 ubiquitin-protein ligase FANCL
UniProt Synonym Protein Names
Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43; RING-type E3 ubiquitin transferase FANCLCurated
UniProt Gene Name
FANCL
UniProt Synonym Gene Names
PHF9; FAAP43
NCBI Protein Information
E3 ubiquitin-protein ligase FANCL

UniProt Comments for FANCL

Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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