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Serpin Peptidase Inhibitor (SERPINB5) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140314

Introduction: SERPINB5 (Maspin) is a tumor suppressor protein of the serine proteinase inhibitor family. Maspin plays a vital role in embryonic development through critical functions in cell adhesion. In addition, Maspin is present in normal breast and… More details

$250 / 0.005 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Serpin Peptidase Inhibitor (SERPINB5), Monoclonal Antibody
Full Product Name
Mouse Anti Human Serpin Peptidase Inhibitor, Clade B Member 5
Product Gene Name
anti-SERPINB5 antibody
Product Synonym Names
SERPINB5 Antibody; Serpin Peptidase Inhibitor Clade B Member 5, Mouse Anti Human; PI5; maspin; SERPINB5; serpin peptidase inhibitor clade B (ovalbumin) member 5; Serpin B5; Protease inhibitor 5
Clonality
Monoclonal
Isotype
IgG2b heavy chain and kappa light chain
Clone Number
PAT2N6AT
Host
Mouse
Form/Format
1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Purity/Purification
SERPINB5 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Preparation and Storage
For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
Molecular Weight
25,763 Da
OMIM
154790
Immunogen
Anti-human SERPINB5 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human SERPINB5 amino acids 1-375 purified from E Coli.

Product Categories/Family for anti-SERPINB5 antibody

Monoclonal/Polyclonal Antibodies; Monoclonal Antibodies
Applications Tested/Suitable for anti-SERPINB5 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-SERPINB5 antibody
SERPINB5 antibody has been tested by ELISA, Western blot analysis and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.

Other Notes

Small volumes of anti-SERPINB5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINB5 purchase

MBS140314 is an antibody targeting SERPINB5. Also known as Mouse Anti Human Serpin Peptidase Inhibitor, Clade B Member 5. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINB5. It may not necessarily be applicable to this product.

NCBI GI #
167860126
NCBI GeneID
5268
NCBI Accession #
NP_002630.2
UniProt Secondary Accession #
Q6N0B4; Q8WW89; B2R6Y4
UniProt Related Accession #
P36952
GenBank Nucleotide #
NM_002639.4
NCBI Official Full Name
serpin B5
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade B (ovalbumin), member 5
NCBI Official Symbol
SERPINB5
NCBI Official Synonym Symbols
PI5; maspin
UniProt Protein Name
Serpin B5
UniProt Synonym Protein Names
Maspin; Peptidase inhibitor 5; PI-5
Protein Family
Serpin
UniProt Gene Name
SERPINB5
UniProt Synonym Gene Names
PI5; PI-5
UniProt Entry Name
SPB5_HUMAN
NCBI Protein Information
serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5

UniProt Comments for SERPINB5

maspin: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18q21.33

Cellular Component: extracellular space; cytoplasm

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding

Biological Process: extracellular matrix organization and biogenesis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation
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Research Articles on SERPINB5

1. Our findings showed that maspin expression, which generally correlates with a less aggressive behavior, is significantly higher in atypical hyperplasia and in endometrial endometrioid adenocarcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SERPINB5 antibody

 Reference Product  PubMed Publications
 TP53 antibody  >4 publications with SERPINB5 and TP53
 PLAU antibody  >3 publications with SERPINB5 and PLAU

Pathways associated with anti-SERPINB5 antibody

 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram

Diseases associated with anti-SERPINB5 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >14 publications with SERPINB5 and Breast Neoplasms
 Carcinoma Antibodies  >13 publications with SERPINB5 and Carcinoma
 Neoplasm Metastasis Antibodies  >10 publications with SERPINB5 and Neoplasm Metastasis
 Inflammation Antibodies  >6 publications with SERPINB5 and Inflammation
 Neoplasm Invasiveness Antibodies  >6 publications with SERPINB5 and Neoplasm Invasiveness
 Lung Neoplasms Antibodies  >6 publications with SERPINB5 and Lung Neoplasms
 Adenocarcinoma Antibodies  >5 publications with SERPINB5 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >4 publications with SERPINB5 and Neoplasms, Experimental
 Lung Diseases Antibodies  >4 publications with SERPINB5 and Lung Diseases
 Colorectal Neoplasms Antibodies  >3 publications with SERPINB5 and Colorectal Neoplasms

Organs/Tissues associated with anti-SERPINB5 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >8 publications with SERPINB5 and Lung
 Prostate Antibodies  >4 publications with SERPINB5 and Prostate
 Bone Antibodies  >4 publications with SERPINB5 and Bone
 Intestine Antibodies  >4 publications with SERPINB5 and Intestine
 Muscle Antibodies  >3 publications with SERPINB5 and Muscle
 Stomach Antibodies  >3 publications with SERPINB5 and Stomach
 Uterus Antibodies  >2 publications with SERPINB5 and Uterus
 Bladder Antibodies  >2 publications with SERPINB5 and Bladder
 Heart Antibodies  >1 publications with SERPINB5 and Heart
 Uncharacterized Tissue Antibodies  >1 publications with SERPINB5 and Uncharacterized Tissue
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