Ubiquitin Conjugating Enzyme E2L 6 (UBE2L6) Antibody – Mouse Monoclonal

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

UBE2L6: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; Ligase; EC 6.3.2.19; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: cytosol

Molecular Function: ISG15 conjugating enzyme activity; protein binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: ISG15-protein conjugation; modification-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway; innate immune response; protein ubiquitination; protein modification process; negative regulation of interferon type I production