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Prolyl 3-Hydroxylase 1 (LEPRE1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1403984

This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated… More details

$1560 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Prolyl 3-hydroxylase 1 (Lepre1), Recombinant Protein
Full Product Name
Recombinant Rat Prolyl 3-hydroxylase 1 (Lepre1)
Product Gene Name
Lepre1 recombinant protein
Product Synonym Gene Name
Lepre1
Sequence
ESEPEWNVAA PDLLYAEGTA AYARGDWPGV VLNMERALRS RAALRALRLR CRTRCATELP WAPDLDLGPA SSLNHDPGAA ALHDLRFFGA LLRRAACLRR CLGPPSAHLL SEELDLEFNK RSPYNYLQVA YFKINKLEKA VAAAHTFFVG NPEHMEMRQN LDYYQTMSGV KEEDFKDLEA KPHMHEFRLG VRLYSEEKPL EAVPHLEAAL QEYFVADEEC RALCEGPYDY DGYNYLDYSA DLFQAITDHY VQVLSCKQNC VTELASHPSR EKPFEDFLPS HYNYLQFAYY NIGNYTQAIE CAKTYLLFFP NDEVMSQNLA YYTAVLGEEE ASSISPRENA QEYRHRSLLE KELLFFAYDI FGIPFVDPDS WTPEEVIPKR LQEKQKSERE TAVRISQEIG NLMKEIETLV EEKTKESLDV SRLTREGGPL LYEGINLTMN SKVLNGSQRV VMDGVISDDE CQELQRLTNA AATSGDGYRG QTSPHTPNEK FYGVTVLKAL KLGQEGKVPL QSAHMYYNVT EKVRRVMESY FRLDTPLYFS YSHLVCRTAI EESQAERKDS SHPVHVDNCI LNAESLVCIK EPPAYTFRDY SAILYLNGDF DGGNFYFTEL DAKTVTAEVQ PQCGRAVGFS SGTENPHGVK AVTRGQRCAI ALWFTLDPRH SERDRVQADD LVKMLFSPEE VDLPQEQPLP DQQGSPKPGE ESLSDRESQP KDEL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
82,390 Da
Sequence Positions
15-728, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9R1J8
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Lepre1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Lepre1 purchase

MBS1403984 is a recombinant protein targeting Lepre1. Also known as Recombinant Rat Prolyl 3-hydroxylase 1 (Lepre1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Lepre1. It may not necessarily be applicable to this product.

NCBI GI #
16758482
NCBI GeneID
114200
NCBI Accession #
NP_446119.1
UniProt Primary Accession #
Q9R1J8
UniProt Related Accession #
Q9R1J8
GenBank Nucleotide #
NM_053667.1
NCBI Official Full Name
prolyl 3-hydroxylase 1
NCBI Official Synonym Full Names
prolyl 3-hydroxylase 1
NCBI Official Symbol
P3h1
NCBI Official Synonym Symbols
Gros1; Lepre1
UniProt Protein Name
Prolyl 3-hydroxylase 1
UniProt Synonym Protein Names
Leucine- and proline-enriched proteoglycan 1
UniProt Gene Name
P3h1
UniProt Synonym Gene Names
Leprecan-1
NCBI Protein Information
prolyl 3-hydroxylase 1

NCBI Summary for Lepre1

basement membrane-associated proteoglycan; may play a role in the secretory pathway of cells [RGD, Feb 2006]

UniProt Comments for Lepre1

Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts ().
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Research Articles on Lepre1

1. Regulated expression of leprecan during glomerular development or hypertrophy coupled with its reported prolyl hydroxylase activity plays a role during basement membrane assembly.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Lepre1 recombinant protein

 Disease Name  Pubmed Publications
 Osteogenesis Imperfecta Antibodies  >40 publications with Lepre1 and Osteogenesis Imperfecta
 Congenital Abnormalities Antibodies  >6 publications with Lepre1 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >4 publications with Lepre1 and Abnormalities, Multiple
 Disease Models, Animal Antibodies  >2 publications with Lepre1 and Disease Models, Animal
 Hypertrophy Antibodies  >2 publications with Lepre1 and Hypertrophy
 Kidney Diseases Antibodies  >1 publications with Lepre1 and Kidney Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with Lepre1 and Urinary Bladder Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with Lepre1 and Cell Transformation, Neoplastic
 Immune System Diseases Antibodies  >1 publications with Lepre1 and Immune System Diseases
 Nervous System Diseases Antibodies  >1 publications with Lepre1 and Nervous System Diseases

Organs/Tissues associated with Lepre1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >10 publications with Lepre1 and Connective Tissue
 Ovary Antibodies  >2 publications with Lepre1 and Ovary
 Brain Antibodies  >2 publications with Lepre1 and Brain
 Testis Antibodies  >1 publications with Lepre1 and Testis
 Heart Antibodies  >1 publications with Lepre1 and Heart
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