Anti-FKBP6 Monoclonal Antibody – Cat# MBS140422

FK506 Binding Protein 6 (FKBP6) Antibody – Monoclonal

Name: FKBP6 Antibody; Monoclonal; MyBioSource
Brand: MyBioSource
SKU: MBS140422
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140422

FKBP6 is part of the immunophilin protein family, and is involved in immunoregulation and basic cellular functions involving protein folding and trafficking. FKBP6 is widely expressed in all tissues, FKBP6 is present at utmost levels in testis, liver, kidney,… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FK506 Binding Protein 6 (FKBP6), Monoclonal Antibody

Full Product Name

Mouse Anti Human FK506 Binding Protein 6

Product Gene Name

anti-FKBP6 antibody

Product Synonym Names

FKBP36, EC 5.2.1.8, FKBP-6, PPIase, MGC87179, FK506-binding protein 6, Rotamase.

Clonality

Monoclonal

Clone Number

PAT9B7A

Purity/Purification

NCK1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.

Preparation and Storage

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.

12 months at -20 degree C. 1 month at 4 degree C.

Molecular Weight

37,516 Da

Type

Mouse Anti Human Monoclonal.

Physical Appearance

Sterile filtered colorless solution.

Immunogen

Anti-human FKBP6 mAb, clone PAT9B7A, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human FKBP6 protein 1-327 amino acids purified from E. coli.

Ig Subclass

Mouse IgG1 heavy chain and Kappa light chain.

Protein formulation

1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.

Product Categories/Family for anti-FKBP6 antibody

Monoclonal Antibodies; Anti-Human Enzymes

Application Notes for anti-FKBP6 antibody

The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.

Other Notes

Small volumes of anti-FKBP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP6 purchase

MBS140422 is an antibody targeting FKBP6. Also known as Mouse Anti Human FK506 Binding Protein 6.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP6. It may not necessarily be applicable to this product.

NCBI GI #

187952137

NCBI GeneID

94244

NCBI Accession #

AAI39098.1

UniProt Secondary Accession #

Q8C1Y1; Q91VB7; Q91Y30

UniProt Related Accession #

Q91XW8

NCBI Official Full Name

FK506 binding protein 6

NCBI Official Synonym Full Names

FK506 binding protein 6

NCBI Official Symbol

Fkbp6

NCBI Official Synonym Symbols

36kDa; FKBP-6; FKBP-36; AU017274; D5Ertd724e; 1700008G22Rik

UniProt Protein Name

Inactive peptidyl-prolyl cis-trans isomerase FKBP6

UniProt Synonym Protein Names

36 kDa FK506-binding protein; 36 kDa FKBP; FKBP-36; FK506-binding protein 6; FKBP-6; Immunophilin FKBP36

Protein Family

FK506-binding protein

UniProt Gene Name

Fkbp6

UniProt Synonym Gene Names

Fkbp36; Inactive PPIase FKBP6; 36 kDa FKBP; FKBP-36; FKBP-6

UniProt Entry Name

FKBP6_MOUSE

NCBI Protein Information

inactive peptidyl-prolyl cis-trans isomerase FKBP6; 36 kDa FK506-binding protein; 36 kDa FKBP; FK506-binding protein 6 (36kD); PPIase FKBP6; immunophilin FKBP36; inactive PPIase FKBP6; rotamase

NCBI Summary for FKBP6

This gene is a member of the FK506-binding protein (Fkbp) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to Hsp90 as a co-chaperone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]

UniProt Comments for FKBP6

FKBP6: PPIases accelerate the folding of proteins. FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 5.2.1.8; Isomerase

Cellular Component: endoplasmic reticulum membrane; membrane; cytoplasm; chromosome; synaptonemal complex; nucleus; cytosol

Molecular Function: FK506 binding; peptidyl-prolyl cis-trans isomerase activity; Hsp90 protein binding

Biological Process: peptidyl-proline modification; meiosis; protein peptidyl-prolyl isomerization; protein folding; meiotic cell cycle; DNA methylation during gametogenesis; RNA-mediated gene silencing; spermatogenesis; cell differentiation

Research Articles on FKBP6

1. study identifies a requirement of mouse Fkbp6 for biogenesis of Miwi2 piRNAs

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FKBP6 antibody

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Meiosis Pathway antibodies	Meiosis Pathway Diagram
Meiotic Synapsis Pathway antibodies	Meiotic Synapsis Pathway Diagram
Meiotic Synapsis Pathway antibodies	Meiotic Synapsis Pathway Diagram
Mus Musculus Biological Processes Pathway antibodies	Mus Musculus Biological Processes Pathway Diagram
PIWI-interacting RNA (piRNA) Biogenesis Pathway antibodies	PIWI-interacting RNA (piRNA) Biogenesis Pathway Diagram
Regulatory RNA Pathways antibodies	Regulatory RNA Pathways Diagram

Diseases associated with anti-FKBP6 antibody

Disease Name	Pubmed Publications
Infertility, Male Antibodies	>11 publications with FKBP6 and Infertility, Male
Cardiovascular Diseases Antibodies	>9 publications with FKBP6 and Cardiovascular Diseases
Congenital Abnormalities Antibodies	>9 publications with FKBP6 and Congenital Abnormalities
Infertility, Female Antibodies	>2 publications with FKBP6 and Infertility, Female
Myocardial Ischemia Antibodies	>1 publications with FKBP6 and Myocardial Ischemia
Neoplasms, Experimental Antibodies	>1 publications with FKBP6 and Neoplasms, Experimental
Uterine Diseases Antibodies	>1 publications with FKBP6 and Uterine Diseases
Heart Defects, Congenital Antibodies	>1 publications with FKBP6 and Heart Defects, Congenital
Uterine Cervical Neoplasms Antibodies	>1 publications with FKBP6 and Uterine Cervical Neoplasms

Organs/Tissues associated with anti-FKBP6 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>10 publications with FKBP6 and Testis
Ovary Antibodies	>1 publications with FKBP6 and Ovary