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Piwi-Like Protein 3 (PIWIL3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1404314

MBS1404314 is a recombinant protein targeting PIWIL3. Also known as Recombinant Human Piwi-like protein 3 (PIWIL3) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1425 / 0.5 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Piwi-like protein 3 (PIWIL3), Recombinant Protein
Full Product Name
Recombinant Human Piwi-like protein 3 (PIWIL3) , partial
Product Gene Name
PIWIL3 recombinant protein
Product Synonym Gene Name
PIWIL3
Sequence
MPGRARTRAR GRARRRESYQ QEAPGGPRAP GSATTQEPPQ LQSTPRPLQE EVPVVRPLQP RAARGGAGGG AQSQGVKEPG PEAGLHTAPL QERRIGGVFQ DLVVNTRQDM KHVKDSKTGS EGTVVQLLAN HFRVISRPQW VAYKYNVDYK PDIEDGNLRT ILLDQHRRKF GERHIFDGNS LLLSRPLKER RVEWLSTTKD KNIVKITVEF SKELTPTSPD CLRYYNILFR RTFKLLDFEQ VGRNYYTKKK AIQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
101,089 Da
Sequence Positions
1-253, Fragment at the N-terminal
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
610314
3D Structure
ModBase 3D Structure for Q7Z3Z3
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PIWIL3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PIWIL3. It may not necessarily be applicable to this product.

NCBI GI #
153792298
NCBI GeneID
440822
NCBI Accession #
NP_001008496.2
UniProt Primary Accession #
Q7Z3Z3
UniProt Related Accession #
Q7Z3Z3
GenBank Nucleotide #
NM_001008496.3
NCBI Official Full Name
piwi-like protein 3 isoform 1
NCBI Official Synonym Full Names
piwi like RNA-mediated gene silencing 3
NCBI Official Symbol
PIWIL3
NCBI Official Synonym Symbols
HIWI3
UniProt Protein Name
Piwi-like protein 3
Protein Family
Piwi-like protein
UniProt Gene Name
PIWIL3
NCBI Protein Information
piwi-like protein 3

NCBI Summary for PIWIL3

This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for PIWIL3

May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation ().
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Research Articles on PIWIL3

1. Our data indicate that PIWIL3 protein expression is elevated in more aggressive primary malignant melanoma(MM )and metastatic disease. As also observed in other malignancies, PIWIL3 seems to play a role in MM progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PIWIL3 recombinant protein

 Products by Pathway  Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram

Diseases associated with PIWIL3 recombinant protein

 Disease Name  Pubmed Publications
 Colorectal Neoplasms Antibodies  >1 publications with PIWIL3 and Colorectal Neoplasms
 Colonic Neoplasms Antibodies  >1 publications with PIWIL3 and Colonic Neoplasms
 Infertility, Male Antibodies  >1 publications with PIWIL3 and Infertility, Male
 Oligospermia Antibodies  >1 publications with PIWIL3 and Oligospermia

Organs/Tissues associated with PIWIL3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >1 publications with PIWIL3 and Testis
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