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Annexin A1 (ANXA1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140473

ANXA1 is part of the family of Ca(2+)-dependent phospholipid binding proteins which have a Mw between 35kDa-40kDa and are situated on the cytosolic face of the plasma membrane. ANXA1 protein has a Mw of 40kDa, with phospholipase A2 inhibitory activity to bind… More details

$250 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Annexin A1 (ANXA1), Monoclonal Antibody
Full Product Name
Mouse Anti Human Annexin A1
Product Gene Name
anti-ANXA1 antibody
Product Synonym Names
ANXA1 Antibody; Annexin A1, Mouse Anti Human; ANX1; LPC1; ANXA1; Lipocortin I; Calpactin II; Chrombindin-9; p35; Annexin-1; Phospholipase A2 inhibitory protein; Annexin I; Annexin A1
Clonality
Monoclonal
Clone Number
PAT2G5AT
Host
Mouse
Species Reactivity
Human
Form/Format
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
Sterile filtered colorless solution.
Purity/Purification
Purified from mouse ascitic fluids by protein-A affinity chromatography
Preparation and Storage
Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
Stability: 12 months at -20 degree C. 1 month at 4 degree C.
Molecular Weight
38,714 Da
OMIM
151690
Ig Subclass
Mouse IgG1 heavy chain and k light chain.
Immunogen
Anti-human ANXA1 mAb, clone PAT2G5AT, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ANXA1 protein 1-346 amino acids purified from E Coli.

Product Categories/Family for anti-ANXA1 antibody

Monoclonal/Polyclonal Antibodies
Applications Tested/Suitable for anti-ANXA1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-ANXA1 antibody
The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity.

Other Notes

Small volumes of anti-ANXA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANXA1 purchase

MBS140473 is an antibody targeting ANXA1. Also known as Mouse Anti Human Annexin A1. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ANXA1. It may not necessarily be applicable to this product.

NCBI GI #
4502101
NCBI GeneID
301
NCBI Accession #
NP_000691.1
UniProt Related Accession #
P04083
GenBank Nucleotide #
NM_000700.2
NCBI Official Full Name
annexin A1
NCBI Official Synonym Full Names
annexin A1
NCBI Official Symbol
ANXA1
NCBI Official Synonym Symbols
ANX1; LPC1
UniProt Protein Name
Annexin A1
UniProt Synonym Protein Names
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I
Protein Family
Annexin
UniProt Gene Name
ANXA1
UniProt Synonym Gene Names
ANX1; LPC1
UniProt Entry Name
ANXA1_HUMAN
NCBI Protein Information
annexin A1

UniProt Comments for ANXA1

ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: apical plasma membrane; cell surface; cell-cell adherens junction; cornified envelope; cytoplasm; early endosome membrane; endosome; extracellular region; extracellular space; extrinsic to external side of plasma membrane; extrinsic to membrane; focal adhesion; lateral plasma membrane; nucleoplasm; nucleus; plasma membrane; vesicle

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; phospholipase A2 inhibitor activity; phospholipid binding; protein binding; protein binding, bridging; receptor binding; structural molecule activity

Biological Process: actin cytoskeleton reorganization; alpha-beta T cell differentiation; G-protein signaling, coupled to cyclic nucleotide second messenger; inflammatory response; keratinocyte differentiation; monocyte chemotaxis; negative regulation of apoptosis; negative regulation of exocytosis; negative regulation of T-helper 2 cell differentiation; neutrophil homeostasis; peptide cross-linking; phagocytosis; positive regulation of interleukin-2 production; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of vesicle fusion; regulation of cell shape; regulation of hormone secretion; regulation of inflammatory response; regulation of interleukin-1 production; regulation of leukocyte migration; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ANXA1 antibody

 Reference Product  PubMed Publications
 FPR2 antibody  >33 publications with ANXA1 and FPR2
 FPR1 antibody  >18 publications with ANXA1 and FPR1
 S100A11 antibody  >6 publications with ANXA1 and S100A11
 FPR3 antibody  >4 publications with ANXA1 and FPR3
 APP antibody  >1 publications with ANXA1 and APP

Pathways associated with anti-ANXA1 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies  Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram

Diseases associated with anti-ANXA1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >100 publications with ANXA1 and Inflammation
 Carcinoma Antibodies  >65 publications with ANXA1 and Carcinoma
 Disease Models, Animal Antibodies  >34 publications with ANXA1 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >25 publications with ANXA1 and Neoplasm Metastasis
 Brain Diseases Antibodies  >22 publications with ANXA1 and Brain Diseases
 Carcinoma, Squamous Cell Antibodies  >19 publications with ANXA1 and Carcinoma, Squamous Cell
 Necrosis Antibodies  >15 publications with ANXA1 and Necrosis
 Neoplasm Invasiveness Antibodies  >14 publications with ANXA1 and Neoplasm Invasiveness
 Cardiovascular Diseases Antibodies  >14 publications with ANXA1 and Cardiovascular Diseases
 Stomach Diseases Antibodies  >12 publications with ANXA1 and Stomach Diseases

Organs/Tissues associated with anti-ANXA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >115 publications with ANXA1 and Blood
 Brain Antibodies  >36 publications with ANXA1 and Brain
 Lung Antibodies  >30 publications with ANXA1 and Lung
 Vascular Antibodies  >23 publications with ANXA1 and Vascular
 Liver Antibodies  >20 publications with ANXA1 and Liver
 Pituitary Gland Antibodies  >15 publications with ANXA1 and Pituitary Gland
 Bone Antibodies  >14 publications with ANXA1 and Bone
 Lymph Node Antibodies  >14 publications with ANXA1 and Lymph Node
 Stomach Antibodies  >13 publications with ANXA1 and Stomach
 Muscle Antibodies  >13 publications with ANXA1 and Muscle
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