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MTHFD2 Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140578

Introduction: MTHFD2 plays a role as a homodimer which requires magnesium and inorganic phosphate. MTHFD2 has a pseudogene on chromosome 7 and owns 3 different enzymatic activities. Each of the activities catalyzes 1 of 3 sequential reactions in the… More details

$250 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MTHFD2, Recombinant Protein
Full Product Name
Recombinant Human MTHFD2
Product Gene Name
MTHFD2 recombinant protein
Product Synonym Names
MTHFD2 Human; MTHFD2 Human Recombinant; Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase; mitochondrial; NAD-dependent methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase; NMDMC; MTHFD2
Sequence
MGSSHHH HHH SSGLVPRGSH MGSLAA VRNE AVVISGRKLA QQIKQEVRQE VEEWVASGNK RPHLSVILVG ENPASHSYVL NKTRAAAVVG INSETIMKPA SISEEELLNL INKLNNDDNV DGLLVQLPLP EHIDERRICN AVSPDKDVDG FHVINVGRMC LDQYSMLPAT PWGVWEIIKR TGIPTLGKNV VVAGRSKNVG MPIAMLLHTD GAHERPGGDA TVTISHRYTP KEQLKKHTIL ADIVISAAGI PNLITADMIK EGAAVIDVGI NRVHDPVTAK PKLVGDVDFE GVRQKAGYIT PVPGGVGPMT VAMLMKNTII AAKKVLRLEE REVLKSKELG VATN.
Host
E Coli
Form/Format
The MTHFD2 solution (1mg/ml) contains Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT.
Sterile Filtered clear solution.
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Molecular Weight
26,849 Da
OMIM
604887
3D Structure
ModBase 3D Structure for P13995

Product Categories/Family for MTHFD2 recombinant protein

Enzymes

Other Notes

Small volumes of MTHFD2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MTHFD2 purchase

MBS140578 is a recombinant protein targeting MTHFD2. Also known as Recombinant Human MTHFD2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MTHFD2. It may not necessarily be applicable to this product.

NCBI GI #
94721354
NCBI GeneID
10797
NCBI Accession #
NP_006627.2
UniProt Primary Accession #
P13995
UniProt Secondary Accession #
Q53G90; Q53GV5; Q53S36; Q7Z650
UniProt Related Accession #
P13995
GenBank Nucleotide #
NM_006636.3
NCBI Official Full Name
bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
NCBI Official Synonym Full Names
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NCBI Official Symbol
MTHFD2
NCBI Official Synonym Symbols
NMDMC
UniProt Protein Name
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Protein Family
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
UniProt Gene Name
MTHFD2
UniProt Synonym Gene Names
NMDMC
UniProt Entry Name
MTDC_HUMAN
NCBI Protein Information
bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

UniProt Comments for MTHFD2

MTHFD2: a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]

Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.15; EC 3.5.4.9; Hydrolase; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cytosol; extracellular space; mitochondrial matrix; mitochondrion

Molecular Function: formate-tetrahydrofolate ligase activity; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; phosphate binding

Biological Process: folic acid metabolic process; one-carbon compound metabolic process; tetrahydrofolate metabolic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MTHFD2 recombinant protein

 Products by Pathway  Pathway Diagram
 C1-unit Interconversion, Eukaryotes Pathway antibodies  C1-unit Interconversion, Eukaryotes Pathway Diagram
 C1-unit Interconversion, Eukaryotes Pathway antibodies  C1-unit Interconversion, Eukaryotes Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 Trans-sulfuration And One Carbon Metabolism Pathway antibodies  Trans-sulfuration And One Carbon Metabolism Pathway Diagram
 Folate Transformations I Pathway antibodies  Folate Transformations I Pathway Diagram

Diseases associated with MTHFD2 recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >6 publications with MTHFD2 and Breast Neoplasms
 Nervous System Diseases Antibodies  >3 publications with MTHFD2 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with MTHFD2 and Inflammation
 Adenocarcinoma Antibodies  >2 publications with MTHFD2 and Adenocarcinoma
 Lung Diseases Antibodies  >1 publications with MTHFD2 and Lung Diseases
 Hypertrophy Antibodies  >1 publications with MTHFD2 and Hypertrophy
 Disease Models, Animal Antibodies  >1 publications with MTHFD2 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >1 publications with MTHFD2 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with MTHFD2 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with MTHFD2 and Liver Neoplasms

Organs/Tissues associated with MTHFD2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with MTHFD2 and Liver
 Lung Antibodies  >2 publications with MTHFD2 and Lung
 Embryonic Tissue Antibodies  >2 publications with MTHFD2 and Embryonic Tissue
 Muscle Antibodies  >2 publications with MTHFD2 and Muscle
 Heart Antibodies  >2 publications with MTHFD2 and Heart
 Bone Antibodies  >1 publications with MTHFD2 and Bone
 Ovary Antibodies  >1 publications with MTHFD2 and Ovary
 Lymph Antibodies  >1 publications with MTHFD2 and Lymph
 Lymph Node Antibodies  >1 publications with MTHFD2 and Lymph Node
 Bladder Antibodies  >1 publications with MTHFD2 and Bladder
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