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TRAIL Receptor-3 (TNFRSF10C) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140622

TNFRSF10C Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 234 amino acids (26-236 a.a) and having a molecular mass of 24.6 kDa.TNFRSF10C is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRAIL Receptor-3 (TNFRSF10C), Recombinant Protein
Full Product Name
Recombinant Human TRAIL Receptor-3
Product Gene Name
TNFRSF10C recombinant protein
Product Synonym Names
TNFRSF10C Human; TRAIL Receptor-3 Human Recombinant; Tumor Necrosis Factor Receptor Superfamily; Member 10c; Decoy Without An; Intracellular Domain; TRAILR3; DCR1; TRID; TNF-Related Apoptosis-Inducing Ligand Receptor; Antagonist Decoy Receptor For TRAIL/Apo-2L; Decoy TRAIL Receptor Without Death Domain; Lymphocyte Inhibitor Of TRAIL; Decoy Receptor;TRAIL-R; LIT;Tumor Necrosis Factor Receptor Superfamily Member 10C; TRAIL Receptor Without an Intracellular Domain; Cytotoxic TRAIL Receptor; TRAIL Receptor; CD263 Antigen; DCR1-TNFR; CD263
Sequence
MGSSHHH HHHSSGLVPR GSH MGSATT ARQEEVPQQT VAPQ QQRHSFKGEE CPAGSHRSEH TGACNPCTEG VDYTNASNNE PSCFPCTVCK SDQKHKSSCT MTRDTVCQCK EGTFRNENSP EMCRKCSRCP SGEVQVSNCT SWDDIQCVEE FGANATVETP AAEETMNTSP GTPAPAAEET MNTSPGTPAP AAEETMTTSP GTPAPAAEET MTTSPGTPAP AAEETMTTSP GTPA
Host
E Coli
Form/Format
TNFRSF10C protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4) and 10% glycerol.
Sterile Filtered clear solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.
Molecular Weight
27,407 Da
OMIM
603613
3D Structure
ModBase 3D Structure for O14798

Product Categories/Family for TNFRSF10C recombinant protein

Cytokines and Growth Factors

Other Notes

Small volumes of TNFRSF10C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF10C purchase

MBS140622 is a recombinant protein targeting TNFRSF10C. Also known as Recombinant Human TRAIL Receptor-3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF10C. It may not necessarily be applicable to this product.

NCBI GI #
22547121
NCBI GeneID
8794
NCBI Accession #
NP_003832.2
UniProt Primary Accession #
O14798
UniProt Secondary Accession #
O14755; Q08AS6; Q6FH98; Q6UXM5
UniProt Related Accession #
O14798
GenBank Nucleotide #
NM_003841.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 10C
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily member 10c
NCBI Official Symbol
TNFRSF10C
NCBI Official Synonym Symbols
LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10C
UniProt Synonym Protein Names
Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD_antigen: CD263
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF10C
UniProt Synonym Gene Names
DCR1; LIT; TRAILR3; TRID; DcR1; TRAIL receptor 3; TRAIL-R3
UniProt Entry Name
TR10C_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10C

UniProt Comments for TNFRSF10C

TRAIL-R3: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: transmembrane receptor activity; tumor necrosis factor receptor activity

Biological Process: immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TNFRSF10C recombinant protein

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram

Diseases associated with TNFRSF10C recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >154 publications with TNFRSF10C and Necrosis
 Adenocarcinoma Antibodies  >24 publications with TNFRSF10C and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >9 publications with TNFRSF10C and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >9 publications with TNFRSF10C and Breast Neoplasms
 Inflammation Antibodies  >8 publications with TNFRSF10C and Inflammation
 Colonic Neoplasms Antibodies  >8 publications with TNFRSF10C and Colonic Neoplasms
 Lung Neoplasms Antibodies  >7 publications with TNFRSF10C and Lung Neoplasms
 Liver Neoplasms Antibodies  >6 publications with TNFRSF10C and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >5 publications with TNFRSF10C and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >5 publications with TNFRSF10C and Neoplasms, Experimental

Organs/Tissues associated with TNFRSF10C recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >39 publications with TNFRSF10C and Blood
 Liver Antibodies  >11 publications with TNFRSF10C and Liver
 Lung Antibodies  >9 publications with TNFRSF10C and Lung
 Uterus Antibodies  >4 publications with TNFRSF10C and Uterus
 Muscle Antibodies  >4 publications with TNFRSF10C and Muscle
 Testis Antibodies  >4 publications with TNFRSF10C and Testis
 Vascular Antibodies  >3 publications with TNFRSF10C and Vascular
 Thyroid Antibodies  >3 publications with TNFRSF10C and Thyroid
 Kidney Antibodies  >3 publications with TNFRSF10C and Kidney
 Placenta Antibodies  >3 publications with TNFRSF10C and Placenta
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