Human CTHRC1 Recombinant Protein – Cat# MBS140629

Collagen Triple Helix Repeat Containing 1 (CTHRC1) Human Recombinant Protein

Name: CTHRC1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS140629
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140629

Introduction: Collagen triple helix repeat-containing protein 1 (CTHRC1) functions as a negative regulator of collagen matrix deposition. CTHRC1 is a secreted 28kDa protein which is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 is… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Collagen Triple Helix Repeat Containing 1 (CTHRC1), Recombinant Protein

Full Product Name

Recombinant Human Collagen Triple Helix Repeat Containing 1, HEK

Product Gene Name

CTHRC1 recombinant protein

Product Synonym Names

CTHRC1 Human, HEK; Collagen Triple Helix Repeat Containing 1 Human Recombinant, HEK; Collagen Triple Helix Repeat Containing 1; Protein NMTC1; CTHRC1

Sequence

SEIPKGKQKA QLRQREVVDL YNGMCLQGPA GVPGRDGSPG ANGIPGTPGI PGRDGFKGEK GECLRESFEE SWTPNYKQCS WSSLNYGIDL GKIAECTFTK MRSNSALRVL FSGSLRLKCR NACCQRWYFT FNGAECSGPL PIEAIIYLDQ GSPEMNSTIN IHRTSSVEGL CEGIGAGLVD VAIWVGTCSD YPKGDASTGW NSVSRIIIEE LPK HHHHHH< /u>.

Host

HEK 293

Form/Format

CTHRC1 was filtered (0.4 um) and lyophilized in phosphate buffered saline pH 7.5.
Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Purity as determined by densitometric image analysis is greater than 95%.

Preparation and Storage

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Molecular Weight

24,770 Da

OMIM

610635

3D Structure

ModBase 3D Structure for Q96CG8

Solubility

It is recommended to add 200 ul deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. CTHRC1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Product Categories/Family for CTHRC1 recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of CTHRC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTHRC1 purchase

MBS140629 is a recombinant protein targeting CTHRC1. Also known as Recombinant Human Collagen Triple Helix Repeat Containing 1, HEK. Host: HEK 293.

Additional Details

NCBI/Uniprot data below describe general gene information for CTHRC1. It may not necessarily be applicable to this product.

NCBI GI #

368711292

NCBI GeneID

115908

NCBI Accession #

NP_001243028.1

UniProt Primary Accession #

Q96CG8

UniProt Secondary Accession #

Q6UW91; Q8IX63; G3V141

UniProt Related Accession #

Q96CG8

GenBank Nucleotide #

NM_001256099.1

NCBI Official Full Name

collagen triple helix repeat-containing protein 1 isoform 2

NCBI Official Synonym Full Names

collagen triple helix repeat containing 1

NCBI Official Symbol

CTHRC1

UniProt Protein Name

Collagen triple helix repeat-containing protein 1

UniProt Synonym Protein Names

Protein NMTC1

Protein Family

Collagen triple helix repeat-containing protein

UniProt Gene Name

CTHRC1

UniProt Entry Name

CTHR1_HUMAN

NCBI Protein Information

collagen triple helix repeat-containing protein 1

UniProt Comments for CTHRC1

CTHRC1: May act as a negative regulator of collagen matrix deposition. Defects in CTHRC1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in CTHRC1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q22.3

Cellular Component: extracellular space

Disease: Barrett Esophagus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CTHRC1 recombinant protein

Products by Pathway	Pathway Diagram
Noncanonical Wnt Signaling Pathway antibodies	Noncanonical Wnt Signaling Pathway Diagram
Wnt Signaling Network Pathway antibodies	Wnt Signaling Network Pathway Diagram

Diseases associated with CTHRC1 recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>24 publications with CTHRC1 and Carcinoma
Adenocarcinoma Antibodies	>15 publications with CTHRC1 and Adenocarcinoma
Gastrointestinal Diseases Antibodies	>14 publications with CTHRC1 and Gastrointestinal Diseases
Neoplasm Metastasis Antibodies	>10 publications with CTHRC1 and Neoplasm Metastasis
Carcinoma, Squamous Cell Antibodies	>8 publications with CTHRC1 and Carcinoma, Squamous Cell
Breast Neoplasms Antibodies	>7 publications with CTHRC1 and Breast Neoplasms
Liver Diseases Antibodies	>7 publications with CTHRC1 and Liver Diseases
Fibrosis Antibodies	>6 publications with CTHRC1 and Fibrosis
Lung Neoplasms Antibodies	>6 publications with CTHRC1 and Lung Neoplasms
Liver Neoplasms Antibodies	>5 publications with CTHRC1 and Liver Neoplasms

Organs/Tissues associated with CTHRC1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>15 publications with CTHRC1 and Vascular
Bone Antibodies	>13 publications with CTHRC1 and Bone
Lung Antibodies	>13 publications with CTHRC1 and Lung
Liver Antibodies	>12 publications with CTHRC1 and Liver
Skin Antibodies	>8 publications with CTHRC1 and Skin
Lymph Node Antibodies	>7 publications with CTHRC1 and Lymph Node
Connective Tissue Antibodies	>6 publications with CTHRC1 and Connective Tissue
Esophagus Antibodies	>6 publications with CTHRC1 and Esophagus
Embryonic Tissue Antibodies	>5 publications with CTHRC1 and Embryonic Tissue
Kidney Antibodies	>4 publications with CTHRC1 and Kidney