Human RANK Recombinant Protein – Cat# MBS140640

RANK Human Recombinant Protein

Name: RANK Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS140640
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140640

Introduction: RANK, is part of the tumor necrosis factor receptor family. RANK is widely expressed with uppermost levels in the skeletal muscle, thymus, liver, colon, small intestine, adrenal gland as well as dendritic cells. Furthermore, in activated human… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RANK, Recombinant Protein

Full Product Name

Recombinant Human RANK

Product Gene Name

RANK recombinant protein

Product Synonym Names

RANK Human; RANK Human Recombinant; Tumor Necrosis Factor Receptor Superfamily; Member 11a; NFKB Activator; Loss Of Heterozygosity; 18; Chromosomal Region 1; Osteoclast Differentiation Factor Receptor; Receptor Activator Of NF-KB; Paget Disease Of Bone 2; ODFR; RANK; Tumor Necrosis Factor Receptor Superfamily; Member 11a; Activator Of NFKB; Receptor Activator Of Nuclear Factor-Kappa B; CD265 Antigen; LOH18CR1; TRANCER; CD265; OPTB7; OSTS; PDB2; FEO; OFE; Tumor necrosis factor receptor superfamily member 11A

Sequence

ADP LQIAPPCTSE KHYEHLG RCCNKCEPGK YMSSKCTTTS DSVCLPCGPD EYLDSWNEED KCLLHKVCDT GKALVAVVAG NSTTPRRCAC TAGYHWSQDC ECCRRNTECA PGLGAQHPLQ LNKDTVCKPC LAGYFSDAFS STDKCRPWTN CTFLGKRVEH HGTEKSDAVC SSSLPARKPP NEPHVYLPLE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PEN NYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH.

Host

Sf9 Baculovirus Cells

Form/Format

RANK protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

64,552 Da

OMIM

174810

3D Structure

ModBase 3D Structure for Q9Y6Q6

Product Categories/Family for RANK recombinant protein

Cytokines and Growth Factors

Other Notes

Small volumes of RANK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RANK purchase

MBS140640 is a recombinant protein targeting RANK. Also known as Recombinant Human RANK. Host: Sf9 Baculovirus Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for RANK. It may not necessarily be applicable to this product.

NCBI GI #

401015111

NCBI GeneID

8792

NCBI Accession #

NP_001257878.1

UniProt Primary Accession #

Q9Y6Q6

UniProt Secondary Accession #

Q59EP9; I4EC36; I4EC38; I4EC39; I7JE63; N0GVH0

UniProt Related Accession #

Q9Y6Q6

GenBank Nucleotide #

NM_001270949.1

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 11A isoform 2

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily member 11a

NCBI Official Symbol

TNFRSF11A

NCBI Official Synonym Symbols

FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 11A

UniProt Synonym Protein Names

Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD_antigen: CD265

Protein Family

Rabankyrin

UniProt Gene Name

TNFRSF11A

UniProt Synonym Gene Names

RANK; ODFR

UniProt Entry Name

TNR11_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 11A

UniProt Comments for RANK

TNFRSF11A: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.1

Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: cytokine binding; protein binding; receptor activity; transmembrane receptor activity; tumor necrosis factor receptor activity

Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; cell-cell signaling; circadian thermoregulation; inflammatory response; osteoclast differentiation; positive regulation of cell proliferation; positive regulation of JNK activity; positive regulation of transcription factor activity; regulation of apoptosis; response to cytokine stimulus; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway

Disease: Familial Expansile Osteolysis; Osteopetrosis, Autosomal Recessive 7; Paget Disease Of Bone

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RANK recombinant protein

Reference Product	PubMed Publications
TNFSF11 recombinant protein	>1513 publications with RANK and TNFSF11
TRAF6 recombinant protein	>65 publications with RANK and TRAF6
FOS recombinant protein	>49 publications with RANK and FOS
SRC recombinant protein	>38 publications with RANK and SRC
TRAF2 recombinant protein	>15 publications with RANK and TRAF2
TRAF1 recombinant protein	>8 publications with RANK and TRAF1
TRAF5 recombinant protein	>8 publications with RANK and TRAF5
TRAF3 recombinant protein	>6 publications with RANK and TRAF3
PIGN recombinant protein	>2 publications with RANK and PIGN

Pathways associated with RANK recombinant protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Osteoclast Signaling Pathway antibodies	Osteoclast Signaling Pathway Diagram
Osteoclast Differentiation Pathway antibodies	Osteoclast Differentiation Pathway Diagram
Osteoclast Differentiation Pathway antibodies	Osteoclast Differentiation Pathway Diagram
Prolactin Signaling Pathway antibodies	Prolactin Signaling Pathway Diagram
Prolactin Signaling Pathway antibodies	Prolactin Signaling Pathway Diagram

Diseases associated with RANK recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>893 publications with RANK and Necrosis
Inflammation Antibodies	>154 publications with RANK and Inflammation
Cardiovascular Diseases Antibodies	>112 publications with RANK and Cardiovascular Diseases
Breast Neoplasms Antibodies	>66 publications with RANK and Breast Neoplasms
Osteitis Deformans Antibodies	>53 publications with RANK and Osteitis Deformans
Neoplasm Metastasis Antibodies	>44 publications with RANK and Neoplasm Metastasis
Osteosarcoma Antibodies	>33 publications with RANK and Osteosarcoma
Kidney Diseases Antibodies	>24 publications with RANK and Kidney Diseases
Neoplasms, Experimental Antibodies	>23 publications with RANK and Neoplasms, Experimental
Heart Diseases Antibodies	>18 publications with RANK and Heart Diseases

Organs/Tissues associated with RANK recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>1408 publications with RANK and Bone
Vascular Antibodies	>81 publications with RANK and Vascular
Skin Antibodies	>24 publications with RANK and Skin
Liver Antibodies	>22 publications with RANK and Liver
Lung Antibodies	>22 publications with RANK and Lung
Brain Antibodies	>21 publications with RANK and Brain
Heart Antibodies	>20 publications with RANK and Heart
Kidney Antibodies	>20 publications with RANK and Kidney
Embryonic Tissue Antibodies	>19 publications with RANK and Embryonic Tissue
Intestine Antibodies	>9 publications with RANK and Intestine